Based on the data from the west China development, the paper carries out the relationship between tourism development, manufacturing agglomeration and economic growth, and it further identifies the effect of tourism expansion on manufacturing agglomeration. The results show that the manufacturing agglomeration has been declining, it doesn’t increase economic growth. And the west tourism overall promotes economic growth. The relationship between tourism development and manufacturing agglomeration is pour U , and at the left side of the curve. So there is no “de-industrialization” effect. But the long time economic growth would become slow if the tourism excessively prospers.