Modeling exotic highly pathogenic avian influenza virus entrance risk through air passenger violations

The highly pathogenic avian influenza virus (HPAIV) is able to survive in poultry products and could be carried into a country by air travelers. An assessment model was constructed to estimate the probability of the exotic viable HPAIV entering Taiwan from two neighboring areas through poultry products carried illegally by air passengers at Taiwan's main airports. The entrance risk was evaluated based on HPAIV-related factors (the prevalence and the incubation period of HPAIV; the manufacturing process of poultry products; and the distribution-storage-transportation factor event) and the passenger event. Distribution functions were adopted to simulate the probabilities of each HPAIV factor. The odds of passengers being intercepted with illegal poultry products were estimated by logistic regression. The Monte Carlo simulation established that the risk caused by HPAIV-related factors from area A was lower than area B, whereas the entrance risk by the passenger event from area A was similar to area B. Sensitivity analysis showed that the incubation period of HPAIV and the interception of passenger violations were major determinants. Although the result showed viable HPAIV was unlikely to enter Taiwan through meat illegally carried by air passengers, this low probability could be caused by incomplete animal disease data and modeling uncertainties. Considering the negative socioeconomic impacts of HPAIV outbreaks, strengthening airport quarantine measures is still necessary. This assessment provides a profile of HPAIV entrance risk through air travelers arriving from endemic areas and a feasible direction for quarantine and public health measures.     

A Quantitative Assessment of the Risks from Illegally Imported Meat Contaminated with Foot and Mouth Disease Virus to Great Britain

Foot and mouth disease (FMD) is considered by many as the most important animal disease in the world. FMD is highly contagious and outbreaks incur significant costs as affected countries are severely limited in their ability to trade. A number of trade commodities may be contaminated with FMD virus (FMDV) including animal products, for example, meat. As a member of the European Union, Great Britain (GB) has put in place a number of regulations to prevent the importation of pathogens in imported meat products. However, the illegal importation of meat provides a route by which safety controls may be circumvented and meat from FMD affected areas may be imported. This study assesses the FMD infection risk posed to the livestock population of GB from the illegal importation of meat, and estimates the major contributors to this overall risk, through the development of a quantitative risk assessment model. From model results, the total amount of illegal meat entering GB each year is estimated on average to be 11,875 tonnes. with 90% certainty that this is between 4,398 and 28,626 tonnes per year; of which between 64.5 and 565 kg are contaminated with FMDV. This flow of illegal meat results in an estimate of a frequency of FMD infection in GB livestock of 0.015 cases of infected animals per year, with 90% certainty it is between 0.0017 and 0.053. Imports from the region Near and Middle East account for 47% of this risk, and 68% of the risk is attributed to bone-in and dried de-boned products.     

Quantitative Risk Assessment of FMD Virus Transmission via Water

Foot-and-mouth disease (FMD) is a viral disease of domesticated and wild cloven-hoofed animals. FMD virus is known to spread by direct contact between infected and susceptible animals, by animal products such as meat and milk, by the airborne route, and mechanical transfer on people, wild animals, birds, and by vehicles. During the outbreak of 2001 in the Netherlands, milk from dairy cattle was illegally discharged into the sewerage as a consequence of transport prohibition. This may lead to contaminated discharges of biologically treated and raw sewage in surface water that is given to cattle to drink. The objective of the present study was to assess the probability of infecting dairy cows that were drinking FMD virus contaminated surface water due to illegal discharges of contaminated milk. So, the following data were collected from literature: FMD virus inactivation in aqueous environments, FMD virus concentrations in milk, dilution in sewage water, virus removal by sewage treatment, dilution in surface water, water consumption of cows, size of a herd in a meadow, and dose-response data for ingested FMD virus by cattle. In the case of 1.6 x 10(2) FMD virus per milliliter in milk and discharge of treated sewage in surface water, the probability of infecting a herd of cows was estimated to be 3.3 x 10(-7) to 8.5 x 10(-5), dependent on dilution in the receiving surface water. In the case of discharge of raw sewage, all probabilities of infection were 100 times higher. In the case of little dilution in small rivers, the high level of 8.5 x 10(-3) is reached. For 10(4) times higher FMD virus concentrations in milk, the probabilities of infecting a herd of cows are high in the case of discharge of treated sewage (3.3 x 10(-3) to 5.7 x 10(-1)) and very high in the case of discharge of raw sewage (0.28-1.0). It can be concluded that illegal and uncontrolled discharges of contaminated milk into the sewerage system may lead to high risks to other cattle farms at 6-50 km distance of the location of discharge within one day. This clearly underlines current measures that prohibit such discharges, and also asks for strict control. This risk assessment clearly demonstrated the potential significance of FMD virus transmission via water, and the results will be useful on an international scale, and could also serve as a basis for other FMD risk-assessment models.     

A Probabilistic Model of the Economic Risk to Britain's Railway Network from Bridge Scour During Floods

Scour (localized erosion by water) is an important risk to bridges, and hence many infrastructure networks, around the world. In Britain, scour has caused the failure of railway bridges crossing rivers in more than 50 flood events. These events have been investigated in detail, providing a data set with which we develop and test a model to quantify scour risk. The risk analysis is formulated in terms of a generic, transferrable infrastructure network risk model. For some bridge failures, the severity of the causative flood was recorded or can be reconstructed. These data are combined with the background failure rate, and records of bridges that have not failed, to construct fragility curves that quantify the failure probability conditional on the severity of a flood event. The fragility curves generated are to some extent sensitive to the way in which these data are incorporated into the statistical analysis. The new fragility analysis is tested using flood events simulated from a spatial joint probability model for extreme river flows for all river gauging sites in Britain. The combined models appear robust in comparison with historical observations of the expected number of bridge failures in a flood event. The analysis is used to estimate the probability of single or multiple bridge failures in Britain's rail network. Combined with a model for passenger journey disruption in the event of bridge failure, we calculate a system‐wide estimate for the risk of scour failures in terms of passenger journey disruptions and associated economic costs.     

Quantitative Assessment of the Risk of Release of Foot‐and‐Mouth Disease Virus via Export of Bull Semen from Israel

Various foot‐and‐mouth disease (FMD) virus strains circulate in the Middle East, causing frequent episodes of FMD outbreaks among Israeli livestock. Since the virus is highly resistant in semen, artificial insemination with contaminated bull semen may lead to the infection of the receiver cow. As a non‐FMD‐free country with vaccination, Israel is currently engaged in trading bull semen only with countries of the same status. The purpose of this study was to assess the risk of release of FMD virus through export of bull semen in order to estimate the risk for FMD‐free countries considering purchasing Israeli bull semen. A stochastic risk assessment model was used to estimate this risk, defined as the annual likelihood of exporting at least one ejaculate of bull semen contaminated with viable FMD virus. A total of 45 scenarios were assessed to account for uncertainty and variability around specific parameter estimates and to evaluate the effect of various mitigation measures, such as performing a preexport test on semen ejaculates. Under the most plausible scenario, the annual likelihood of exporting bull semen contaminated with FMD virus had a median of 1.3 * 10^?7 for an export of 100 ejaculates per year. This corresponds to one infected ejaculate exported every 7 million years. Under the worst‐case scenario, the median of the risk rose to 7.9 * 10^?5, which is equivalent to the export of one infected ejaculate every 12,000 years. Sensitivity analysis indicated that the most influential parameter is the probability of viral excretion in infected bulls.     

Passenger and pilot risk minimization in offshore helicopter transportation

In the offshore petroleum industry, employees are transported to and from the offshore installations by helicopter, which represents a major risk. This paper analyzes how to improve transportation safety by solving the helicopter routing problem with a risk objective expressed in terms of expected number of fatalities. A mathematical model is proposed and a tabu search heuristic is applied to this problem. Three routing policies are considered: a direct routing policy, a Hamiltonian routing policy, and a general routing policy. Extensive computational experiments are conducted on instances derived from real data in order to assess and compare these policies under a travel time, a passenger risk and a combined passenger and pilot risk objective. Several management insights can be derived from this study. In particular, our results show that passenger transportation risk can be reduced by increasing travel time at the expense of pilot risk. This can be achieved through a reduction of the average number of passengers onboard by applying either a Hamiltonian or a general routing policy. Our methodology can also be used to derive an equitable distribution of risk between passengers and pilots, considering that pilots fly much more frequently than passengers.     

Minimizing takeoff and landing risk in helicopter pickup and delivery operations

The problem of minimizing total helicopter passenger risk caused by takeoffs and landings is studied. There are passenger pickup and delivery demands to be satisfied at given points by flights starting and ending in the same heliport and visiting several points. For each point, the delivery demand is the number of passengers to be transported from the heliport to this point and the pickup demand is the number of different passengers to be transported from this point to the heliport. Each pickup and delivery demand must be satisfied in full by one flight. There are an upper bound on the number of flights and an upper bound on the helicopter passenger capacity. The objective function is a linear combination of the numbers of passengers involved in takeoffs and landings at visited points. A solution is characterized by the number of flights, sets of visited points and their sequences for all flights. Properties of optimal solutions are established. Several cases are proved NP-hard. A quadratic boolean programming formulation and two dynamic programming algorithms are suggested for the general case. Computer experiments demonstrated that they are able to solve real-life instances. Polynomial time algorithms are presented for special cases. Implementation of the suggested solutions into the real helicopter operations should decrease the number of fatalities.     

A Probabilistic Transmission Model to Assess Infection Risk from Mycobacterium Tuberculosis in Commercial Passenger Trains

The objective of this article is to characterize the risk of infection from airborne Mycobacterium tuberculosis bacilli exposure in commercial passenger trains based on a risk‐based probabilistic transmission modeling. We investigated the tuberculosis (TB) infection risks among commercial passengers by inhaled aerosol M. tuberculosis bacilli and quantify the patterns of TB transmission in Taiwan High Speed Rail (THSR). A deterministic Wells‐Riley mathematical model was used to account for the probability of infection risk from M. tuberculosis bacilli by linking the cough‐generated aerosol M. tuberculosis bacilli concentration and particle size distribution. We found that (i) the quantum generation rate of TB was estimated with a lognormal distribution of geometric mean (GM) of 54.29 and geometric standard deviation (GSD) of 3.05 quantum/h at particle size ≤ 5 μm and (ii) the basic reproduction numbers (R₀) were estimated to be 0.69 (0.06–6.79), 2.82 (0.32–20.97), and 2.31 (0.25–17.69) for business, standard, and nonreserved cabins, respectively. The results indicate that commercial passengers taking standard and nonreserved cabins had higher transmission risk than those in business cabins based on conservatism. Our results also reveal that even a brief exposure, as in the bronchoscopy cases, can also result in a transmission when the quantum generation rate is high. This study could contribute to a better understanding of the dynamics of TB transmission in commercial passenger trains by assessing the relationship between TB infectiousness, passenger mobility, and key model parameters such as seat occupancy, ventilation rate, and exposure duration.     

Probability of Exporting Infected Carcasses from Vaccinated Pigs Following a Foot‐and‐Mouth Disease Epidemic

Emergency vaccination is an effective control strategy for foot‐and‐mouth disease (FMD) epidemics in densely populated livestock areas, but results in a six‐month waiting period before exports can be resumed, incurring severe economic consequences for pig exporting countries. In the European Union, a one‐month waiting period has been discussed based on negative test results in a final screening. The objective of this study was to analyze the risk of exporting FMD‐infected pig carcasses from a vaccinated area: (1) directly after final screening and (2) after a six‐month waiting period. A risk model has been developed to estimate the probability that a processed carcass was derived from an FMD‐infected pig (P_carc). Key variables were herd prevalence (P_H), within‐herd prevalence (P_A), and the probability of detection at slaughter (P_SL). P_H and P_A were estimated using Bayesian inference under the assumption that, despite all negative test results, ≥1 infected pigs were present. Model calculations indicated that P_carc was on average 2.0 × 10^?5 directly after final screening, and 1.7 × 10^?5 after a six‐month waiting period. Therefore, the additional waiting time did not substantially reduce P_carc. The estimated values were worst‐case scenarios because only viraemic pigs pose a risk for disease transmission, while seropositive pigs do not. The risk of exporting FMD via pig carcasses from a vaccinated area can further be reduced by heat treatment of pork and/or by excluding high‐risk pork products from export.     

The Impact of Joint Responses of Devices in an Airport Security System

In this article, we consider a model for an airport security system in which the declaration of a threat is based on the joint responses of inspection devices. This is in contrast to the typical system in which each check station independently declares a passenger as having a threat or not having a threat. In our framework the declaration of threat/no-threat is based upon the passenger scores at the check stations he/she goes through. To do this we use concepts from classification theory in the field of multivariate statistics analysis and focus on the main objective of minimizing the expected cost of misclassification. The corresponding correct classification and misclassification probabilities can be obtained by using a simulation-based method. After computing the overall false alarm and false clear probabilities, we compare our joint response system with two other independently operated systems. A model that groups passengers in a manner that minimizes the false alarm probability while maintaining the false clear probability within specifications set by a security authority is considered. We also analyze the staffing needs at each check station for such an inspection scheme. An illustrative example is provided along with sensitivity analysis on key model parameters. A discussion is provided on some implementation issues, on the various assumptions made in the analysis, and on potential drawbacks of the approach.     

Collaborative optimization for metro train scheduling and train connections combined with passenger flow control strategy

For high-frequency metro lines, the excessive travel demand during the peak hours brings a high risk to metro system and a low comfort to passengers, so it is important to consider passenger flow control when designing the metro train scheduling strategy. This paper presents a collaborative optimization method for metro train scheduling and train connections combined with passenger control strategy on a bi-directional metro line. Specifically, the dynamic equations for the train headway and train passenger loads along the metro line, the turnaround operations and the entering/exiting depot operations are considered simultaneously. The proposed collaborative optimization problem is formulated as a mixed integer nonlinear programming model to realise the trade-off among the utilization of trains, passenger flow control strategy and the number of awaiting passengers at platforms, which is further reformulated into mixed integer linear programming (MILP) model. To handle the complexity of this MILP model, a Lagrangian relaxation-based approach is designed to decompose the original problem into two small subproblems, which reduces the computational burden of the original problem and can efficiently find a good solution of the train schedule and train connections problem combined with passenger flow control strategy. The numerical experiments are implemented to investigate the effectiveness of the proposed model and approach, which shows that the proposed model is not sensitive to uncertain passenger demand. Under the proposed collaborative optimization approach, the number of train service connections and the crowding inside stations and carriages with the proper passenger flow control strategy can be evidently balanced, and thereby the operation efficiency and safety of the metro lines are effectively improved.     

Lies in the Sky: Effects of Employee Dishonesty on Organizational Reputation in the Airline Industry

Conventional wisdom suggests that dishonesty on the part of an organization's employees has a negative effect on the organization's reputation. However, many organizations condone (or even require) dishonesty under certain circumstances. In this research of 128 airline passengers, we examine situations in which employees are perceived to be dishonest within one such industry, the international airlines, and examine the impact of this dishonesty on organizational reputation and customer satisfaction. We found that the reputation of the firm was most damaged when the lie benefited the company or the employee, rather than the passenger. In addition, the view of the airline significantly decreased when the lie caused a high amount of harm (compared with a low amount) to the passenger.     

Health-Based Population Forecasting: Effects of Smoking on Mortality and Fertility

A microsimulation model, allowing one to forecast short- and long-term population changes conditional on the prevalence of a risk factor in a population, is presented. In this model, population changes result from the aggregation of changes in individual event histories, which, in turn, result from mortality and infertility rates recalculated in accordance with their known relative risks in population groups exposed to a risk factor. Smoking, being the most widespread and influential preventable public health risk factor, is chosen to demonstrate the abilities of the model to forecast the population effects of different hypothetical smoking prevalences. The demographic and population health effects on 20-, 50-, and 100-year projections with the current, hypothetically doubled, and hypothetically halved the current smoking prevalence are analyzed in detail. The model predicts an increase in life expectancy (0.99 year for males and 0.64 years for females), and an increase in population size (2.2-7.5% dependent on the age group) if smoking prevalence is reduced by half. Sensitivity analyses of all findings are performed. The generalization of the model to account for multiple risk factors (e.g., the simultaneous effects of alcohol consumption, obesity, and smoking) and effects on medical expenditures are discussed.     

COVID-19疫情下一种新的地铁平峰运营策略

地铁在城市交通中发挥着重要作用。然而，在新冠肺炎(COVID-19)疫情下，地铁的运营出现了包括消毒、限流及出行独立等多重约束。错峰出行成为了众多城市地铁运营过程中的必然选择。如何既满足居民的基本出行需求，为顺利实现复工复学提供交通支持，又能有效降低乘客感染病毒的风险与追踪密切接触者的成本成为了城市地铁运营的新目标。本文通过对北京地铁运营现状及居民的出行规律分析发现，在新型冠状病毒疫情下，地铁运营过程中存在出行需求与地铁运力不匹配，复工复产与疫情防控，乘客交叉出行数量过多等难题，并针对以上难题提出了分时段复工出行与周末可复工在内的复杂指派模型。这一指派模型不仅实现了城市关键地铁站点平峰人流量、降低疫情传播风险及追踪难度的目标，同时通过模型目标函数与约束条件的灵活修改可实现更为复杂的乘坐地铁复工复产目标。本文所提出的模型在复杂周期性平峰问题中具有较强的推广应用价值。     

服务质量、需求强度与共享出行平台定价——基于平台封闭与开放策略的视角

共享出行平台逐步由增加用户流量的扩张期进入提升出行多元化体验的稳定期,通过采取开放策略,平台在原有共享车基础上引入出租车来提供差异化服务。本文基于双边市场理论,构建共享出行平台定价策略模型,并利用计算实验方法,在Repast中模拟共享出行平台多智能体运行场景。研究发现：①无论平台选择封闭策略还是开放策略,平台对共享车收取的交易费应随着乘客出行需求强度增大而升高,且应随着共享车服务质量的增大而降低;平台对乘客收取的交易费应随着共享车服务质量增大而升高,且应随着乘客的出行强度的增大而降低。②平台开放程度越高,平台对共享车收取的交易费越低,对乘客收取的交易费越高。③为了利润最大化,平台应选择开放策略,并需注重提高共享车的服务质量。本文为共享出行平台优化运营策略提供了理论指导。     

Quantitative microbiological risk assessment of nontyphoidal Salmonella in ground pork in households in Chengdu,China

Foodborne disease caused by nontyphoidal Salmonella (NTS) is one of the most important food safety issues worldwide. The objectives of this study were to carry out microbial monitoring on the prevalence of NTS in commercial ground pork, investigate consumption patterns, and conduct a quantitative microbiological risk assessment (QMRA) that considers cross-contamination to determine the risk caused by consuming ground pork and ready-to-eat food contaminated during food handling in the kitchen in Chengdu, China. The food pathway of ground pork was simplified and assumed to be several units according to the actual situation and our survey data, which were collected from our research or references and substituted into the QMRA model for simulation. The results showed that the prevalence of NTS in ground pork purchased in Chengdu was 69.64% (95% confidence interval [CI], 60.2–78.0), with a mean contamination level of −0.164 log CFU/g. After general cooking, NTS in ground pork could be eliminated (contamination level of zero). The estimated probability of causing salmonellosis per day was 9.43E-06 (95% CI: 8.82E-06–1.00E-05), while the estimated salmonellosis cases per million people per year were 3442 (95% CI: 3218–3666). According to the sensitivity analysis, the occurrence of cross-contamination was the most important factor affecting the probability of salmonellosis. To reduce the risk of salmonellosis caused by NTS through ground pork consumption, reasonable hygiene prevention and control measures should be adopted during food preparation to reduce cross-contamination. This study provides valuable information for household cooking and food safety management in China.     

Risk Assessment for Aflatoxin: III. Modeling the Relative Risk of Hepatocellular Carcinoma

Estimates have been made of the cancer potency of aflatoxin exposure among the U.S. population. Risk modeling is used to assess the dose-response relationship between aflatoxin exposure and primary liver cancer, controlling for hepatitis B virus (HBV), based on data provided by the Yeh et al. study in China. A relative risk model is proposed as a more appropriate alternative to the additive ("absolute" risk) model for transportation of risk coefficients between populations with different baseline rates. Several general relative risk models were examined; the exponential model provided the best fit. The Poisson regression method was used to fit the relative risk model to the grouped data. The effects of exposure to aflatoxin (AFB1) and hepatitis B infection were both found to be statistically significant. The risk of death from liver cancer for those exposed to AFB1 relative to the unexposed population, increases by 0.05% per ng/kg/day exposure of AFB1 (p less than 0.001). The results also indicated a 25-fold increase in the risk of death from liver cancer among those infected with hepatitis B virus, relative to noncarriers (p less than 0.0001). With a hepatitis prevalence rate of 1%, the aflatoxin intake level associated with liver cancer lifetime excess risk of 1 x 10(-5) for the U.S. population was estimated as 253 ng/day, based on a liver cancer baseline rate of 3.4/100,000/yr.     

Estimation of Tuberculosis Risk on a Commercial Airliner

This article estimates the risk of tuberculosis (TB) transmission on a typical commercial airliner using a simple one box model (OBM) and a sequential box model (SBM). We used input data derived from an actual TB exposure on an airliner, and we assumed a hypothetical scenario that a highly infectious TB source case (i.e., 108 infectious quanta per hour) travels as a passenger on an 8.7-hour flight. We estimate an average risk of TB transmission on the order of 1 chance in 1,000 for all passengers using the OBM. Applying the more realistic SBM, we show that the risk and incidence decrease sharply in a stepwise fashion in cabins downstream from the cabin containing the source case assuming some potential for airflow from more contaminated to less contaminated cabins. We further characterized spatial variability in the risk within the cabin by modeling a previously reported TB outbreak in an airplane to demonstrate that the TB cases occur most likely within close proximity of the source TB patient.     

Influenza Infection Risk and Predominate Exposure Route: Uncertainty Analysis

An effective nonpharmaceutical intervention for influenza interrupts an exposure route that contributes significantly to infection risk. Herein, we use uncertainty analysis (point‐interval method) and Monte Carlo simulation to explore the magnitude of infection risk and predominant route of exposure. We utilized a previously published mathematical model of a susceptible person attending a bed‐ridden infectious person. Infection risk is sensitive to the magnitude of virus emission and contact rates. The contribution of droplet spray exposure to infection risk increases with cough frequency, and decreases with virus concentration in cough particles. We consider two infectivity scenarios: greater infectivity of virus deposited in the upper respiratory tract than virus inhaled in respirable aerosols, based on human studies; and equal infectivity in the two locations, based on studies in guinea pigs. Given that virus have equal probability of infection throughout the respiratory tract, the mean overall infection risk is 9.8 × 10^?2 (95th percentile 0.78). However, when virus in the upper respiratory tract is less infectious than inhaled virus, the overall infection risk is several orders of magnitude lower. In this event, inhalation is a significant exposure route. Contact transmission is important in both infectivity scenarios. The presence of virus in only respirable particles increases the mean overall infection risk by 1–3 orders of magnitude, with inhalation contributing ≥ 99% of the infection risk. The analysis indicates that reduction of uncertainties in the concentration of virus in expiratory particles of different sizes, expiratory event frequency, and infectivity at different sites in the respiratory tract will clarify the predominate exposure routes for influenza.     

An Approach to Assessing the Impacts of Incident-Free Transportation of Radioactive Materials: I. Air Transportation

Annual radiation doses and risks to passengers and crew are calculated for shipments of radioactive materials in passenger aircraft under accident-free and incident-free conditions (i.e., under normal transportation conditions). The 1982 database developed by Sandia National Laboratories is used, and calculations are made using RADTRAN 4.0. This paper is one of two papers estimating radiological risk associated with incident-free transportation of radioactive materials.