Joint confidence regions in the multivariate calibration problem

Consider a vector valued response variable related to a vector valued explanatory variable through a normal multivariate linear model. The multivariate calibration problem deals with statistical inference on unknown values of the explanatory variable. The problem addressed is the construction of joint confidence regions for several unknown values of the explanatory variable. The problem is investigated when the variance covariance matrix is a scalar multiple of the identity matrix and also when it is a completely unknown positive definite matrix. The problem is solved in only two cases: (i) the response and explanatory variables have the same dimensions, and (ii) the explanatory variable is a scalar. In the former case, exact joint confidence regions are derived based on a natural pivot statistic. In the latter case, the joint confidence regions are only conservative. Computational aspects and the practical implementation of the confidence regions are discussed and illustrated using an example.     

Inference for multivariate normal hierarchical models

This paper provides a new method and algorithm for making inferences about the parameters of a two-level multivariate normal hierarchical model. One has observed J p -dimensional vector outcomes, distributed at level 1 as multivariate normal with unknown mean vectors and with known covariance matrices. At level 2, the unknown mean vectors also have normal distributions, with common unknown covariance matrix A and with means depending on known covariates and on unknown regression coefficients. The algorithm samples independently from the marginal posterior distribution of A by using rejection procedures. Functions such as posterior means and covariances of the level 1 mean vectors and of the level 2 regression coefficient are estimated by averaging over posterior values calculated conditionally on each value of A drawn. This estimation accounts for the uncertainty in A , unlike standard restricted maximum likelihood empirical Bayes procedures. It is based on independent draws from the exact posterior distributions, unlike Gibbs sampling. The procedure is demonstrated for profiling hospitals based on patients' responses concerning p =2 types of problems (non-surgical and surgical). The frequency operating characteristics of the rule corresponding to a particular vague multivariate prior distribution are shown via simulation to achieve their nominal values in that setting.     

Alternate test statistics for a functional errors-in-variables model

Some test statistics for the structural coefficients of simultaneous equations model often referred to as the multivariate linear functional relationship model are proposed in this article. The following cases are considered: the covariance matrix of errors is either unknown, known up to a proportionality factor, or completely known. The exact and approximate distributions of the proposed test statistics, as well as those of some that are known, are also given.     

Parametric and permutation testing for multivariate monotonic alternatives

We are firstly interested in testing the homogeneity of k mean vectors against two-sided restricted alternatives separately in multivariate normal distributions. This problem is a multivariate extension of Bartholomew (in Biometrica 46:328–335, 1959b) and an extension of Sasabuchi et al. (in Biometrica 70:465–472, 1983) and Kulatunga and Sasabuchi (in Mem. Fac. Sci., Kyushu Univ. Ser. A: Mathematica 38:151–161, 1984) to two-sided ordered hypotheses. We examine the problem of testing under two separate cases. One case is that covariance matrices are known, the other one is that covariance matrices are unknown but common. For the general case that covariance matrices are known the test statistic is obtained using the likelihood ratio method. When the known covariance matrices are common and diagonal, the null distribution of test statistic is derived and its critical values are computed at different significance levels. A Monte Carlo study is also presented to estimate the power of the test. A test statistic is proposed for the case when the common covariance matrices are unknown. Since it is difficult to compute the exact p-value for this problem of testing with the classical method when the covariance matrices are completely unknown, we first present a reformulation of the test statistic based on the orthogonal projections on the closed convex cones and then determine the upper bounds for its p-values. Also we provide a general nonparametric solution based on the permutation approach and nonparametric combination of dependent tests.     

Testing equality of two normal covariance matrices with monotone missing data

Abstract

The problem of testing equality of two multivariate normal covariance matrices is considered. Assuming that the incomplete data are of monotone pattern, a quantity similar to the Likelihood Ratio Test Statistic is proposed. A satisfactory approximation to the distribution of the quantity is derived. Hypothesis testing based on the approximate distribution is outlined. The merits of the test are investigated using Monte Carlo simulation. Monte Carlo studies indicate that the test is very satisfactory even for moderately small samples. The proposed methods are illustrated using an example.     

Critical values and powers for tests of uniformity of directions under multivariate normality

The Rayleigh, Ajne, Giné and two new tests of uniformity of directions are investigated as tests for multivariate normality when the population mean vector and covariance matrix are assumed to be unknown. The new tests include one which is designed especially to detect for bimodal alternatives and one which is designed to perform well under a wide variety of alternatives. Simulated percentile points are obtained under the assumption that the variates constitute a random sample from a multivariate normal distribution. Powers of the five tests are compared under alternatives in the bivariate as well as higher dimensional settings.     

Confidence regions for the common mean vector of several multivariate normal populations

Suppose that there are independent samples available from several multivariate normal populations with the same mean vector m? but possibly different covariance matrices. The problem of developing a confidence region for the common mean vector based on all the samples is considered. An exact confidence region centered at a generalized version of the well-known Graybill-Deal estimator of m? is developed, and a multiple comparison procedure based on this confidence region is outlined. Necessary percentile points for constructing the confidence region are given for the two-sample case. For more than two samples, a convenient method of approximating the percentile points is suggested. Also, a numerical example is presented to illustrate the methods. Further, for the bivariate case, the proposed confidence region and the ones based on individual samples are compared numerically with respect to their expected areas. The numerical results indicate that the new confidence region is preferable to the single-sample versions for practical use.     

Upper Bound for p-Value of the Test of Multivariate Normal Ordered Mean Vectors Against all Alternatives

Consider the problem of testing the isotonic of several p-variate normal mean vectors against all alternatives. It is difficult to compute the exact p-value for this problem of testing with the classical method when the covariance matrices are completely unknown. In the present paper, a test statistic is proposed for this problem of testing. A reformulation of the test statistic is given based on the orthogonal projections on the closed convex cones and then the upper bound for p-value of the test statistic is computed.     

Distribution of multivariate quadratic forms under certain covariance structures

Necessary and sufficient conditions are given for the covariance structure of all the observations in a multivariate factorial experiment under which certain multivariate quadratic forms are independent and distributed as a constant times a Wishart. It is also shown that exact multivariate test statistics can be formed for certain covariance structures of the observations when the assumption of equal covariance matrices for each normal population is relaxed. A characterization is given for the dependency structure between random vectors in which the sample mean and sample covariance matrix have certain properties.     

On estimating a function of the mean of a multivariate normal distribution

The unique minimum variance of unbiased estimator is obtained for analysis functions of the mean of a multivariate normal distribution with either unknown covariance matrix or with covariance matrix of the form σ²v where σ² is unknown.     

On the estimation of the mean vector of a multivariate normal distribution under symmetry

The problem of estimation of the mean vector of a multivariate normal distribution with unknown covariance matrix, under uncertain prior information (UPI) that the component mean vectors are equal, is considered. The shrinkage preliminary test maximum likelihood estimator (SPTMLE) for the parameter vector is proposed. The risk and covariance matrix of the proposed estimato are derived and parameter range in which SPTMLE dominates the usual preliminary test maximum likelihood estimator (PTMLE) is investigated. It is shown that the proposed estimator provides a wider range than the usual premilinary test estimator in which it dominates the classical estimator. Further, the SPTMLE has more appropriate size for the preliminary test than the PTMLE.     

A parametric bootstrap solution to the MANOVA under heteroscedasticity

In this article, we consider the problem of comparing several multivariate normal mean vectors when the covariance matrices are unknown and arbitrary positive definite matrices. We propose a parametric bootstrap (PB) approach and develop an approximation to the distribution of the PB pivotal quantity for comparing two mean vectors. This approximate test is shown to be the same as the invariant test given in [Krishnamoorthy and Yu, Modified Nel and Van der Merwe test for the multivariate Behrens–Fisher problem, Stat. Probab. Lett. 66 (2004), pp. 161–169] for the multivariate Behrens–Fisher problem. Furthermore, we compare the PB test with two existing invariant tests via Monte Carlo simulation. Our simulation studies show that the PB test controls Type I error rates very satisfactorily, whereas other tests are liberal especially when the number of means to be compared is moderate and/or sample sizes are small. The tests are illustrated using an example.     

The risks for usual sequential estimates and stopping times of multivariate normal mean for conjugate distribution

The exact formulas of optimal stopping times for usual problems are often difficult to derive. Biekej and Yahav (1965) had provided the large sample approximation known as the asymptotically pointwise optimal (A. P.O.) rule. In Nagao (1997a.b). he has derived the asymptotic formulas for Bayes stopping times for the problems of the mean of a multivariate normal distribution when a covariance matrix is completely unknown and has some structure, respectively. This paper gives the risks for estimate and stopping times which we use in common for some problems. From this result, we find that its increasing amount shows the deficiency of estimate and stopping usually used from the view of the Bayes risk.     

Maximum likelihood estimates in the multivariate normal with patterned mean and covariance via the em algorithm

The maximum likelihood equations for a multivariate normal model with structured mean and structured covariance matrix may not have an explicit solution. In some cases the model's error term may be decomposed as the sum of two independent error terms, each having a patterned covariance matrix, such that if one of the unobservable error terms is artificially treated as "missing data", the EM algorithm can be used to compute the maximum likelihood estimates for the original problem. Some decompositions produce likelihood equations which do not have an explicit solution at each iteration of the EM algorithm, but within-iteration explicit solutions are shown for two general classes of models including covariance component models used for analysis of longitudinal data.     

TEST OF FIT FOR THE INVERSE GAUSSIAN AND GAMMA DISTRIBUTIONS UNDER CENSORING

The problem of testing the fit of the inverse Gaussian and the gamma distribution when the sample is censored and some of the parameters are unknown, is studied. Empirical Distribution Function (EDF) statistics, namely Cramér-von Mises' W ² and the Anderson-Darling's A ², are used. The limiting covariance functions of the corresponding empirical processes are derived. Asymptotic percentage points are given for some parameter values and censoring proportions. Moreover, a numerical routine is made available upon request, to obtain p-values for both test statistics, thus eliminating the need of tables and interpolation. Finally, a simple Monte Carlo study is presented to evaluate first, the approximation when using the asymptotic distributions in finite samples and second, to support the use of estimated parameter values instead of the unknown parameters needed in the limiting covariance function.     

Multivariate tests comparing binomial probabilities, with application to safety studies for drugs

Summary.  In magazine advertisements for new drugs, it is common to see summary tables that compare the relative frequency of several side-effects for the drug and for a placebo, based on results from placebo-controlled clinical trials. The paper summarizes ways to conduct a global test of equality of the population proportions for the drug and the vector of population proportions for the placebo. For multivariate normal responses, the Hotelling T ²-test is a well-known method for testing equality of a vector of means for two independent samples. The tests in the paper are analogues of this test for vectors of binary responses. The likelihood ratio tests can be computationally intensive or have poor asymptotic performance. Simple quadratic forms comparing the two vectors provide alternative tests. Much better performance results from using a score-type version with a null-estimated covariance matrix than from the sample covariance matrix that applies with an ordinary Wald test. For either type of statistic, asymptotic inference is often inadequate, so we also present alternative, exact permutation tests. Follow-up inferences are also discussed, and our methods are applied to safety data from a phase II clinical trial.     

Accurate computation of single and product moments of order statistics under progressive censoring

An accurate procedure is proposed to calculate approximate moments of progressive order statistics in the context of statistical inference for lifetime models. The study analyses the performance of power series expansion to approximate the moments for location and scale distributions with high precision and smaller deviations with respect to the exact values. A comparative analysis between exact and approximate methods is shown using some tables and figures. The different approximations are applied in two situations. First, we consider the problem of computing the large sample variance–covariance matrix of maximum likelihood estimators. We also use the approximations to obtain progressively censored sampling plans for log-normal distributed data. These problems illustrate that the presented procedure is highly useful to compute the moments with precision for numerous censoring patterns and, in many cases, is the only valid method because the exact calculation may not be applicable.     

Estimation of the MSE matrix of the stein estimator

Uniformly minimum-variance unbiased (UMVU) estimators of the total risk and the mean-squared-error (MSE) matrix of the Stein estimator for the multivariate normal mean with unknown covariance matrix are proposed. The estimated MSE matrix is helpful in identifying the components which contribute most to the total risk. It also contains information about the performance of the shrinkage estimator with respect to other quadratic loss functions.     

A new heteroskedasticity-consistent covariance matrix estimator for the linear regression model

The assumption that all random errors in the linear regression model share the same variance (homoskedasticity) is often violated in practice. The ordinary least squares estimator of the vector of regression parameters remains unbiased, consistent and asymptotically normal under unequal error variances. Many practitioners then choose to base their inferences on such an estimator. The usual practice is to couple it with an asymptotically valid estimation of its covariance matrix, and then carry out hypothesis tests that are valid under heteroskedasticity of unknown form. We use numerical integration methods to compute the exact null distributions of some quasi-t test statistics, and propose a new covariance matrix estimator. The numerical results favor testing inference based on the estimator we propose.