Box-Cox transformed linear models: A parameter-based asymptotic approach

A Box-Cox transformed linear model usually has the form y(λ) = μ + β₁x₁ +… + β_px_p + oe, where y(λ) is the power transform of y. Although widely used in practice, the Fisher information matrix for the unknown parameters and, in particular, its inverse have not been studied seriously in the literature. We obtain those two important matrices to put the Box-Cox transformed linear model on a firmer ground. The question of how to make inference on β = (β₁,…,β_p)^T when λ; is estimated from the data is then discussed for large but finite sample size by studying some parameter-based asymptotics. Both unconditional and conditional inference are studied from the frequentist point of view.     

SOME ASYMPTOTIC PROPERTIES OF THE SIMPLE LOGLINEAR MODEL

Consistency and asymptotic normality of the maximum likelihood estimator of β in the loglinear model E(y_i) = e^α+βXi, where y_i are independent Poisson observations, 1 iaan, are proved under conditions which are near necessary and sufficient. The asymptotic distribution of the deviance test for β=β₀ is shown to be chi-squared with 1 degree of freedom under the same conditions, and a second order correction to the deviance is derived. The exponential model for censored survival data is also treated by the same methods.     

THE OPTIMAL CLASSIFICATION RULE FOR EXPONENTIAL POPULATIONS

Let π₁ and π₂ be two exponential populations with location parameters α and β respectively. It is shown that the probability of misclassification for the optimal rule, R_E, depends on α and β only through their ratio α/β=r, and that the smaller the ratio r (i.e. the smaller α is compared to β), the greater the superiority of the optimal rule R_E over the commonly used rule R_N. When α and β are unknown, the sample-based version R_E(s) of R_E exhibits the same pattern of superiority over the sample-based R_N(s) of R_N.     

A Note on Stagewise Regression

Suppose one estimates the coefficient β₂ in E[Y] = β₀ + β₁ X ₁ + β₂ X ₂ by stagewise regression. That is, first the model E[Y] ≌ β₀ + β₁ X ₁ is fit using simple linear regression followed by a simple linear regression of the residuals from this model on X ₂ to yield the estimator β₂. The ratio of the squared t statistic for the estimate b ₂ from multiple regression to the squared t statistic for β₂ is greater than or equal to 1.0 and is shown to be a convenient function of correlation coefficients among Y, X ₁, and X ₂. Examination of stagewise regression can provide useful insights when introducing concepts of multiple regression.     

Heine process as a q-analog of the Poisson process—waiting and interarrival times

In this study, we introduce the Heine process, {X_q(t), t > 0}, 0 < q < 1, where the random variable X_q(t), for every t > 0, represents the number of events (occurrences or arrivals) during a time interval (0, t]. The Heine process is introduced as a q-analog of the basic Poisson process. Also, in this study, we prove that the distribution of the waiting time W_{ν, q}, ν ? 1, up to the νth arrival, is a q-Erlang distribution and the interarrival times T_{k, q} = W_{k, q} ? W_{k ? 1, q},?k = 1, 2, …, ν with W_{0, q} = 0 are independent and equidistributed with a q-Exponential distribution.     

Efficient estimates in linear and nonlinear regression with heteroscedastic errors

In this paper we consider the heteroscedastic regression model defined by the structural relation Y = r(V, β) + s(W)ε, where V is a p-dimensional random vector, W is a q-dimensional random vector, β is an unknown vector in some open subset B of R^m, r is a known function from R^p × B into R, s is an unknown function on R^q, and ε is an unobservable random variable that is independent of the pair (V, W). We construct asymptotically efficient estimates of the regression parameter β under mild assumptions on the functions r and s and on the distributions of ε and (V, W).     

Two‐stage model selection procedures in partially linear regression

The authors propose a two‐stage estimation procedure for the partially linear model Y = f_o(T) + X'β_o + ψ. They show how to estimate consistently the location of the nonzero components of β_o. Their approach turns out to be compatible with minimax adaptive estimation of f_o over Besov balls in the case of penalized least squares. Their proofs are based on a new type of oracle inequality.     

Data Dependent Cells Chi‐Square Test With Recurrent Events

We consider a recurrent event wherein the inter‐event times are independent and identically distributed with a common absolutely continuous distribution function F. In this article, interest is in the problem of testing the null hypothesis that F belongs to some parametric family where the q‐dimensional parameter is unknown. We propose a general Chi‐squared test in which cell boundaries are data dependent. An estimator of the parameter obtained by minimizing a quadratic form resulting from a properly scaled vector of differences between Observed and Expected frequencies is used to construct the test. This estimator is known as the minimum chi‐square estimator. Large sample properties of the proposed test statistic are established using empirical processes tools. A simulation study is conducted to assess the performance of the test under parameter misspecification, and our procedures are applied to a fleet of Boeing 720 jet planes' air conditioning system failures.     

OPTIMAL DESIGNS FOR FITTING A PROPORTIONAL HAZARDS REGRESSION MODEL TO DATA SUBJECT TO CENSORING

Suppose the probability model for failure time data, subject to censoring, is specified by the hazard function λ(t)exp(β_T x), where x is a vector of covariates. Analytical difficulties involved in finding the optimal design are avoided by assuming that λ is completely specified and by using D-optimality based on the information matrix for β Optimal designs are found to depend on β, but some results of practical consequence are obtained. It is found that censoring does not affect the choice of design appreciably when β^T x ≥ 0 for all points of the feasible region, but may have an appreciable effect when β_ix_i 0, for all i and all points in the feasible experimental region. The nature of the effect is discussed in detail for the cases of one and two parameters. It is argued that in practical biomedical situations the optimal design is almost always the same as for uncensored data.     

On the error term in bahadur's representation of an order statistic

Bahadur (1966) presented a representation of an order statistic, giving its asymptotic distribution and the rate of convergence, under weak assumptions on the density function of the parent distribution. In this paper we consider the mean(squared) deviation of the error term in Bahadur’s approximation of the q th sample quantile (q_n ). We derive a uniform bound on the mean (squared) deviation of q_n , not depending on the value of q. An application of the given result provides the corresponding result for a kernel type estimator of the q th quantile.     

Efficiency of the generalized difference-based Liu estimators in semiparametric regression models with correlated errors

In this paper, a generalized difference-based estimator is introduced for the vector parameter β in the semiparametric regression model when the errors are correlated. A generalized difference-based Liu estimator is defined for the vector parameter β in the semiparametric regression model. Under the linear nonstochastic constraint Rβ=r, the generalized restricted difference-based Liu estimator is given. The risk function for the β?_GRD(η) associated with weighted balanced loss function is presented. The performance of the proposed estimators is evaluated by a simulated data set.     

Shelf-life and its estimation in drug stability studies

One important property of any drug product is its stability over time. Drug stability studies are routinely carried out in the pharmaceutical industry in order to measure the degradation of an active pharmaceutical ingredient of a drug product. One important study objective is to estimate the shelf-life of the drug; the estimated shelf-life is required by the US Food and Drug Administration to be printed on the package label of the drug. This involves a suitable definition of the true shelf-life and the construction of an appropriate estimate of the true shelf-life. In this paper, the true shelf-life T_β is defined as the time point at which 100β% of all the individual dosage units (e.g. tablets) of the drug have the active ingredient content no less than the lowest acceptable limit L, where β and L are prespecified constants. The value of T_β depends on the parameters of the assumed degradation model of the active ingredient content and so is unknown. A lower confidence bound T?_β for T_β is then provided and used as the estimated shelf-life of the drug.     

Corrected p-values for tests based on estimated nuisance parameters

In some situations the asymptotic distribution of a random function T _n() that depends on a nuisance parameter is tractable when has known value. In that case it can be used as a test statistic, if suitably constructed, for some hypothesis. However, in practice, often needs to be replaced by an estimator S _n. In this paper general results are given concerning the asymptotic distribution of T _n(S _n) that include special cases previously dealt with. In particular, some situations are covered where the usual likelihood theory is nonregular and extreme values are employed to construct estimators and test statistics.     

A Class of Multivariate Distributions

In this paper we introduce a class of multivariate distributions, known as the generalized Liouville distribution and defined by the functional form (0 ≤x_i < ∞, αi > 0, β_i > 0, q_i > 0). It is shown that such distributions can be used to derive both the Dirichlet distribution and the beta distribution of the second kind.     

Estimated Generalized Least Squares for a Heteroscedastic Regression Model

This paper considers the general linear regression model yc = X₁β+u_t under the heteroscedastic structure E(u_t) = 0, E(u²) =σ²- (X_tβ)², E(u_t u_s) = 0, tæs, t, s= 1, T. It is shown that any estimated GLS estimator for β is asymptotically equivalent to the GLS estimator under some regularity conditions. A three-step GLS estimator, which calls upon the assumption E(u_t²) =s?²(X,β)² for the estimation of the disturbance covariance matrix, is considered.     

Another Proof of Borel's Strong Law of Large Numbers

Let X be a continuous nonnegative random variable with finite first and second moments and a continuous pdf that is positive on the interior of its support. A nonzero limiting density at the origin and a coefficient of variation (CV) greater than 1 are shown to be sufficient conditions for the distribution truncated below at t > 0 to have a variance greater than the variance of the full distribution. Distributions that satisfy these conditions include those with decreasing hazard rates (e.g., the gamma and Weibull distributions with shape parameters less than 1) and the beta distribution with parameter values p and q for which q > p(p + q + 1). The bound T for which truncation at 0 < t < T increases the variance relative to the full distribution is shown to be greater than the (1 — 1/CV)th percentile of the full distribution.     

D-Optimal Axial Designs for Quadratic and Cubic Additive Mixture Models

The paper discusses D-optimal axial designs for the additive quadratic and cubic mixture models σ_1≤i≤q(β_ix_i + β_iix²_i) and σ_1≤i≤q(β_ix_i + β_iix²_i + β_iiix³_i), where x_i≥ 0, x₁ + . . . + x_q = 1. For the quadratic model, a saturated symmetric axial design is used, in which support points are of the form (x₁, . . . , x_q) = [1 ? (q?1)δ_i, δ_i, . . . , δ_i], where i = 1, 2 and 0 ≤δ₂ <_{δ1 ≤} 1/(q ?1). It is proved that when 3 ≤q≤ 6, the above design is D-optimal if δ₂ = 0 and δ₁ = 1/(q?1), and when q≥ 7 it is D-optimal if δ₂ = 0 and δ₁ = [5q?1 ? (9q²?10q + 1)^1/2]/(4q²). Similar results exist for the cubic model, with support points of the form (x₁, . . . , x_q) = [1 ? (q?1)δ_i, δ_i, . . . , δ_i], where i = 1, 2, 3 and 0 = δ₃ <_δ2 < δ_{1 ≤}1/(q?1). The saturated D-optimal axial design and D-optimal design for the quadratic model are compared in terms of their efficiency and uniformity.     

Nonparametric two‐step regression estimation when regressors and error are dependent

This paper considers estimation of the function g in the model Y_t = g(X_t ) + ?_t when E(?_t|Xt) ≠ 0 with nonzero probability. We assume the existence of an instrumental variable Z_t that is independent of ?_t, and of an innovation ηt = X_t — E(X_t|Z_t). We use a nonparametric regression of X_t on Z_t to obtain residuals η_t, which in turn are used to obtain a consistent estimator of g. The estimator was first analyzed by Newey, Powell & Vella (1999) under the assumption that the observations are independent and identically distributed. Here we derive a sample mean‐squared‐error convergence result for independent identically distributed observations as well as a uniform‐convergence result under time‐series dependence.     

A Non‐parametric ANOVA‐type Test for Regression Curves Based on Characteristic Functions

This article studies a new procedure to test for the equality of k regression curves in a fully non‐parametric context. The test is based on the comparison of empirical estimators of the characteristic functions of the regression residuals in each population. The asymptotic behaviour of the test statistic is studied in detail. It is shown that under the null hypothesis, the distribution of the test statistic converges to a finite combination of independent chi‐squared random variables with one degree of freedom. The coefficients in this linear combination can be consistently estimated. The proposed test is able to detect contiguous alternatives converging to the null at the rate n ^{? 1 ∕ 2}. The practical performance of the test based on the asymptotic null distribution is investigated by means of simulations.