Testing overdispersion in data with censoring using the mixture of exponential families

This resean h extends the mixture of exponential family developed by Dean (1992) to accommodate oveidispeision in data with censoring. Score statistics testing the (Existence of overdispersion based on the proposed model are obtained Simulations show that the test statistics have suffcient power in detecting the existence of overdispersion when sample size are sufficiently large and the degree of censoring is mild (i. e, 40%) The test statistics are applied to real data sets and are able to detect overdispersion in those data sets.     

Comparing waiting times in a multi-stage model: A log-rank approach

A proper log-rank test for comparing two waiting (i.e. sojourn, gap) times under right censored data has been absent in the survival literature. The classical log-rank test provides a biased comparison even under independent right censoring since the censoring induced on the time since state entry depends on the entry time unless the hazards are semi-Markov. We develop test statistics for comparing K waiting time distributions from a multi-stage model in which censoring and waiting times may be dependent upon the transition history in the multi-stage model. To account for such dependent censoring, the proposed test statistics utilize an inverse probability of censoring weighted (IPCW) approach previously employed to define estimators for the cumulative hazard and survival function for waiting times in multi-stage models. We develop the test statistics as analogues to K-sample log-rank statistics for failure time data, and weak convergence to a Gaussian limit is demonstrated. A simulation study demonstrates the appropriateness of the test statistics in designs that violate typical independence assumptions for multi-stage models, under which naive test statistics for failure time data perform poorly, and illustrates the superiority of the test under proportional hazards alternatives to a Mann–Whitney type test. We apply the test statistics to an existing data set of burn patients.     

协整参数的自举推断

 针对完全修正最小二乘(full-modified ordinary least square,简称FMOLS）估计方法,给出一种协整参数的自举推断程序,证明零假设下自举统计量与检验统计量具有相同的渐近分布。关于检验功效的研究表明,虽然有约束自举的实际检验水平表现良好,但如果零假设不成立,自举统计量的分布是不确定的,因而其经验分布不能作为检验统计量精确分布的有效估计。实际应用中建议使用无约束自举,因为无论观测数据是否满足零假设,其自举统计量与零假设下检验统计量都具有相同的渐近分布。最后,利用蒙特卡洛模拟对自举推断和渐近推断的有限样本表现进行比较研究。     

Hypothesis Testing of Hazard Ratio Parameters in Marginal Models for Multivariate Failure Time Data

Marginal hazard models for multivariate failure time data have been studied extensively in recent literature. However, standard hypothesis test statistics based on the likelihood method are not exactly appropriate for this kind of model. In this paper, extensions of the three commonly used likelihood hypothesis test statistics are discussed. Generalized Wald, generalized score and generalized likelihood ratio tests for hazard ratio parameters in a marginal hazard model for multivariate failure time data are proposed and their asymptotic distributions examined. The finite sample properties of these statistics are studied through simulations. The proposed method is applied to data from Busselton Population Health Surveys.     

Testing for a change point in a sequence of exponential random variables with repeated values

Two test statistics are proposed for the change-point problem with repeated values when the data follow an exponential distribution. The properties of these two statistics have been studied and their asymptotic distributions under the alternative have been derived. The powers of the two test statistics are compared. Real-data examples are presented to illustrate the application of these tests.     

Using entropy distance measures for testing odds ratio parameters under logistic regression models based on case–control data

We propose two retrospective test statistics for testing the vector of odds ratio parameters under the logistic regression model based on case–control data by exploiting the density ratio structure under a two-sample semiparametric model, which is equivalent to the assumed logistic regression model. The proposed test statistics are based on Kullback–Leibler entropy distance and are particularly relevant to the case–control sampling plan. These two test statistics have identical asymptotic chi-squared distributions under the null hypothesis and identical asymptotic noncentral chi-squared distributions under local alternatives to the null hypothesis. Moreover, the proposed test statistics require computation of the maximum semiparametric likelihood estimators of the underlying parameters, but are otherwise easily computed. We present some results on simulation and on the analysis of two real data sets.     

A family of test statistics for trend change in mean residual life with unknown turning point using censored data

In this paper, we develop a family of test statistics for testing exponentiality against increasing then decreasing mean residual life alternatives to accommodate the randomly censored data when neither the change point nor the proportion is known. We establish the asymptotic null distribution of test statistics. Monte Carlo simulations are conducted to investigate the speed of convergence of test statistics to the asymptotic null distribution and study the performance of test statistics by the power of tests.     

Multivariate hypothesis testing using generalized and {2}-inverses – with applications

The use of generalized inverses in Wald's-type quadratic forms of test statistics having singular normal limiting distributions does not guarantee to obtain chi-square limiting distributions. In this article, the use of {2} -inverses for that problem is investigated. Alternatively, Imhof-based test statistics can also be defined, which converge in distribution to weighted sum of chi-square variables. The asymptotic distributions of these test statistics under the null and alternative hypotheses are discussed. Under fixed and local alternatives, the asymptotic powers are compared theoretically. Simulation studies are also performed to compare the exact powers of the test statistics in finite samples. A data analysis on the temperature and precipitation variability in the European Alps illustrates the proposed methods.     

Powers of Discrete Goodness-of-Fit Test Statistics for a Uniform Null Against a Selection of Alternative Distributions

The comparative powers of six discrete goodness-of-fit test statistics for a uniform null distribution against a variety of fully specified alternative distributions are discussed. The results suggest that the test statistics based on the empirical distribution function for ordinal data (Kolmogorov–Smirnov, Cramér–von Mises, and Anderson–Darling) are generally more powerful for trend alternative distributions. The test statistics for nominal (Pearson's chi-square and the nominal Kolmogorov–Smirnov) and circular data (Watson's test statistic) are shown to be generally more powerful for the investigated triangular (∨), flat (or platykurtic type), sharp (or leptokurtic type), and bimodal alternative distributions.     

An evaluation of methods for testing hypotheses relating to two endpoints in a single clinical trial

The issues and dangers involved in testing multiple hypotheses are well recognised within the pharmaceutical industry. In reporting clinical trials, strenuous efforts are taken to avoid the inflation of type I error, with procedures such as the Bonferroni adjustment and its many elaborations and refinements being widely employed. Typically, such methods are conservative. They tend to be accurate if the multiple test statistics involved are mutually independent and achieve less than the type I error rate specified if these statistics are positively correlated. An alternative approach is to estimate the correlations between the test statistics and to perform a test that is conditional on those estimates being the true correlations. In this paper, we begin by assuming that test statistics are normally distributed and that their correlations are known. Under these circumstances, we explore several approaches to multiple testing, adapt them so that type I error is preserved exactly and then compare their powers over a range of true parameter values. For simplicity, the explorations are confined to the bivariate case. Having described the relative strengths and weaknesses of the approaches under study, we use simulation to assess the accuracy of the approximate theory developed when the correlations are estimated from the study data rather than being known in advance and when data are binary so that test statistics are only approximately normally distributed.     

Parametric bootstrap and approximate tests for two Poisson variates

The parametric bootstrap tests and the asymptotic or approximate tests for detecting difference of two Poisson means are compared. The test statistics used are the Wald statistics with and without log-transformation, the Cox F statistic and the likelihood ratio statistic. It is found that the type I error rate of an asymptotic/approximate test may deviate too much from the nominal significance level α under some situations. It is recommended that we should use the parametric bootstrap tests, under which the four test statistics are similarly powerful and their type I error rates are all close to α. We apply the tests to breast cancer data and injurious motor vehicle crash data.     

Testing for a change in repeated measures data

Four nonparametric test statistics for the change-point problem with repeated measures data are proposed. In a Monte Carlo simulation study, critical values for the proposed test statistics are simulated and the performances of the proposed tests are compared with the performances of some competitive tests in terms of asymptotic behavior and power. We provide appropriate recommendations for different occurrences of the change-point and illustrate the testing methods using a set of real data.     

Goodness-of-fit Tests for Semi-Markov and Markov Survival Models with One Intermediate State

Survival data with one intermediate state are described by semi-Markov and Markov models for counting processes whose intensities are defined in terms of two stopping times T ₁< T ₂. Problems of goodness-of-fit for these models are studied. The test statistics are proposed by comparing Nelson–Aalen estimators for data stratified according to T ₁. Asymptotic distributions of these statistics are established in terms of the weak convergence of some random fields. Asymptotic consistency of these test statistics is also established. Simulation studies are included to indicate their numerical performance.     

A Necessary Power Divergence Type Family Tests of Multivariate Normality

In a recent article, Cardoso de Oliveira and Ferreira have proposed a multivariate extension of the univariate chi-squared normality test, using a known result for the distribution of quadratic forms in normal variables. In this article, we propose a family of power divergence type test statistics for testing the hypothesis of multinormality. The proposed family of test statistics includes as a particular case the test proposed by Cardoso de Oliveira and Ferreira. We assess the performance of the new family of test statistics by using Monte Carlo simulation. In this context, the type I error rates and the power of the tests are studied, for important family members. Moreover, the performance of significant members of the proposed test statistics are compared with the respective performance of a multivariate normality test, proposed recently by Batsidis and Zografos. Finally, two well-known data sets are used to illustrate the method developed in this article as well as the specialized test of multivariate normality proposed by Batsidis and Zografos.     

Divergence-based tests of homogeneity for spatial data

The problem of testing homogeneity in contingency tables when the data are spatially correlated is considered. We derive statistics defined as divergences between unrestricted and restricted estimated joint cell probabilities and we show that they are asymptotically distributed as linear combinations of chi-square random variables under the null hypothesis of homogeneity. Monte Carlo simulation experiments are carried out to investigate the behavior of the new divergence test statistics and to make comparisons with the statistics that do not take into account the spatial correlation. We show that some of the introduced divergence test statistics have a significantly better behavior than the classical chi-square test for the problem under consideration when we compare them on the basis of the simulated sizes and powers.     

A Class of Goodness-of-fit Tests Based on Transformation

There is an increasing number of goodness-of-fit tests whose test statistics measure deviations between the empirical characteristic function and an estimated characteristic function of the distribution in the null hypothesis. With the aim of overcoming certain computational difficulties with the calculation of some of these test statistics, a transformation of the data is considered. To apply such a transformation, the data are assumed to be continuous with arbitrary dimension, but we also provide a modification for discrete random vectors. Practical considerations leading to analytic formulas for the test statistics are studied, as well as theoretical properties such as the asymptotic null distribution, validity of the corresponding bootstrap approximation, and consistency of the test against fixed alternatives. Five applications are provided in order to illustrate the theory. These applications also include numerical comparison with other existing techniques for testing goodness-of-fit.     

Testing hypotheses for the growth curve model when the data are incomplete

Kleinbaum (1973) developed a generalized growth curve model for analyzing incomplete longitudinal data. In this paper the small sample properties of several related test statistics are investigated via Monte Carlo techniques. The covariance matrix is estimated by each of three non-iterative methods. The null and non-null distributions of these test statistics are examined.     

Testing overdispersion in the zero-inflated Poisson model

The zero-inflated negative binomial (ZINB) model is used to account for commonly occurring overdispersion detected in data that are initially analyzed under the zero-inflated Poisson (ZIP) model. Tests for overdispersion (Wald test, likelihood ratio test [LRT], and score test) based on ZINB model for use in ZIP regression models have been developed. Due to similarity to the ZINB model, we consider the zero-inflated generalized Poisson (ZIGP) model as an alternate model for overdispersed zero-inflated count data. The score test has an advantage over the LRT and the Wald test in that the score test only requires that the parameter of interest be estimated under the null hypothesis. This paper proposes score tests for overdispersion based on the ZIGP model and illustrates that the derived score statistics are exactly the same as the score statistics under the ZINB model. A simulation study indicates the proposed score statistics are preferred to other tests for higher empirical power. In practice, based on the approximate mean–variance relationship in the data, the ZINB or ZIGP model can be considered, and a formal score test based on asymptotic standard normal distribution can be employed for assessing overdispersion in the ZIP model. We provide an example to illustrate the procedures for data analysis.     

Testing equality of correlation coefficients for paired binary data from multiple groups

Paired binary data arise naturally when paired body parts are investigated in clinical trials. One of the widely used models for dealing with this kind of data is the equal correlation coefficients model. Before using this model, it is necessary to test whether the correlation coefficients in each group are actually equal. In this paper, three test statistics (likelihood ratio test, Wald-type test, and Score test) are derived for this purpose. The simulation results show that the Score test statistic maintains type I error rate and has satisfactory power, and therefore is recommended among the three methods. The likelihood ratio test is over conservative in most cases, and the Wald-type statistic is not robust with respect to empirical type I error. Three real examples, including a multi-centre Phase II double-blind placebo randomized controlled trial, are given to illustrate the three proposed test statistics.     

Testing hypotheses in truncated samples by means of divergence statistics

In this paper we consider the problem of testing hypotheses in parametric models, when only the first r (of n) ordered observations are known.Using divergence measures, a procedure to test statistical hypotheses is proposed, Replacing the parameters by suitable estimators in the expresion of the divergence measure, the test statistics are obtained.Asymptotic distributions for these statistics are given in several cases when maximum likelihood estimators for truncated samples are considered.Applications of these results in testing statistical hypotheses, on the basis of truncated data, are presented.The small sample behavior of the proposed test statistics is analyzed in particular cases.A comparative study of power values is carried out by computer simulation.