The use of an identity in Anderson for multivariate multiple testing

Consider the model where there are I$I$ independent multivariate normal treatment populations with p×1$p\times 1$ mean vectors _μi${\mathit{\mu }}_i$, i=1,…,I$i=1,\dots ,I$, and covariance matrix Σ$\Sigma$. Independently the (I+1)$(I+1)$st population corresponds to a control and it too is multivariate normal with mean vector _μI+1${\mathit{\mu }}_{I+1}$ and covariance matrix Σ$\Sigma$. Now consider the following two multiple testing problems.     

A sequential design for a clinical trial with a linear prognostic factor

We study a randomized adaptive design to assign one of the L$L$ treatments to patients who arrive sequentially by means of an urn model. At each stage n$n$, a reward is distributed between treatments. The treatment applied is rewarded according to its response, 0?_Yn?1$0?Y_n?1$, and 1-_Yn$1-Y_n$ is distributed among the other treatments according to their performance until stage n-1$n-1$. Patients can be classified in K+1$K+1$ levels and we assume that the effect of this level in the response to the treatments is linear. We study the asymptotic behavior of the design when the ordinary least square estimators are used as a measure of performance until stage n-1$n-1$.     

On asymptotic properties of the parameter estimator for a type of SPDE

In this paper, we study a random field _U?(t,x)$U_{?}(t,x)$ governed by some type of stochastic partial differential equations with an unknown parameter θ$\theta$ and a small noise ?$?$. We construct an estimator of θ$\theta$ based on the continuous observation of N   Fourier coefficients of _U?(t,x)$U_{?}(t,x)$, and prove the strong convergence and asymptotic normality of the estimator when the noise ?$?$ tends to zero.     

Reduced-rank estimation of the difference between two covariance matrices

We consider m×m$m\times m$ covariance matrices, _Σ1${\Sigma }_1$ and _Σ2${\Sigma }_2$, which satisfy _Σ2-_Σ1=Δ${\Sigma }_2-{\Sigma }_1=\Delta$, where Δ$\Delta$ has a specified rank. Maximum likelihood estimators of _Σ1${\Sigma }_1$ and _Σ2${\Sigma }_2$ are obtained when sample covariance matrices having Wishart distributions are available and rank(Δ)$\text{rank}(\Delta )$ is known. The likelihood ratio statistic for a test about the value of rank(Δ)$\text{rank}(\Delta )$ is also given and some properties of its null distribution are obtained. The methods developed in this paper are illustrated through an example.     

Optimally robust credible sets with a class of priors

We determine a credible set A   that is the “best” with respect to the variation of the prior distribution in a neighborhood Γ$\Gamma$ of the starting prior _π0(θ)${\pi }_0(\theta )$. Among the class of sets with credibility γ$\gamma$ under _π0${\pi }_0$, the “optimally robust” set will be the one which maximizes the minimum probability of including θ$\theta$ as the prior varies over Γ$\Gamma$. This procedure is also Γ-minimax$\Gamma \text{-minimax}$ with respect to the risk function, probability of non-inclusion. We find the optimally robust credible set for three neighborhood classes Γ$\Gamma$, the ε-contamination$\epsilon \text{-contamination}$ class, the density ratio class and the density bounded class. A consequence of this investigation is that the maximum likelihood set is seen to be an optimal credible set from a robustness perspective.     

Characterizations based on record values and order statistics

Consider a sequence of independent and identically distributed random variables {_Xi,i?1}$\{X_i,i?1\}$ with a common absolutely continuous distribution function F  . Let _X1:n?_X2:n???_Xn:n$X_{1:n}?X_{2:n}???X_{n:n}$ be the order statistics of {_X1,_X2,…,_Xn}$\{X_1,X_2,\dots ,X_n\}$ and {_Yl,l?1}$\{Y_l,l?1\}$ be the sequence of record values generated by {_Xi,i?1}$\{X_i,i?1\}$. In this work, the conditional distribution of _Yl$Y_l$ given _Xn:n$X_{n:n}$ is established. Some characterizations of F   based on record values and _Xn:n$X_{n:n}$ are then given.     

Truncated linear estimation of a bounded multivariate normal mean

We consider the problem of estimating the mean θ$\theta$ of an _Np(θ,_Ip)${\mathrm{N}}_{\mathrm{p}}(\theta ,I_p)$ distribution with squared error loss ∥δ−θ∥²$\parallel \delta -\theta {\parallel }^2$ and under the constraint ∥θ∥≤m$\parallel \theta \parallel \le m$, for some constant m>0$m>0$. Using Stein's identity to obtain unbiased estimates of risk, Karlin's sign change arguments, and conditional risk analysis, we compare the risk performance of truncated linear estimators with that of the maximum likelihood estimator _δmle${\delta }_{\mathrm{mle}}$. We obtain for fixed (m,p)$(m,p)$ sufficient conditions for dominance. An asymptotic framework is developed, where we demonstrate that the truncated linear minimax estimator dominates _δmle${\delta }_{\mathrm{mle}}$, and where we obtain simple and accurate measures of relative improvement in risk. Numerical evaluations illustrate the effectiveness of the asymptotic framework for approximating the risks for moderate or large values of p.     

Optimal mixed-level k-circulant supersaturated designs

Supersaturated designs (SSDs) offer a potentially useful way to investigate many factors with only few experiments in the preliminary stages of experimentation. This paper explores how to construct E(_fNOD)$E(f_{\mathrm{NOD}})$-optimal mixed-level SSDs using k-cyclic generators. The necessary and sufficient conditions for the existence of mixed-level k-circulant SSDs with the equal occurrence property are provided. Properties of the mixed-level k  -circulant SSDs are investigated, in particular, the sufficient condition under which the generator vector produces an E(_fNOD)$E(f_{\mathrm{NOD}})$-optimal SSD is obtained. Moreover, many new E(_fNOD)$E(f_{\mathrm{NOD}})$-optimal mixed-level SSDs are constructed and listed. The method here generalizes the one proposed by Liu and Dean [2004. k$k$-circulant supersaturated designs. Technometrics 46, 32–43] for two-level SSDs and the one due to Georgiou and Koukouvinos [2006. Multi-level k-circulant supersaturated designs. Metrika 64, 209–220] for the multi-level case.     

An identity for the Fisher information and Mahalanobis distance

Consider a mixture problem consisting of k classes. Suppose we observe an s-dimensional random vector X   whose distribution is specified by the relations P(X∈A|Y=i)=_Pi(A)$P(X\in A|Y=i)=P_i(A)$, where Y   is an unobserved class identifier defined on {1,…,k}$\{1,\dots ,k\}$, having distribution P(Y=i)=_pi$P(Y=i)=p_i$. Assuming the distributions _Pi$P_i$ having a common covariance matrix, elegant identities are presented that connect the matrix of Fisher information in Y   on the parameters _p1,…,_pk$p_1,\dots ,p_k$, the matrix of linear information in X, and the Mahalanobis distances between the pairs of P  's. Since the parameters are not free, the information matrices are singular and the technique of generalized inverses is used. A matrix extension of the Mahalanobis distance and its invariant forms are introduced that are of interest in their own right. In terms of parameter estimation, the results provide an independent of the parameter upper bound for the loss of accuracy by esimating _p1,…,_pk$p_1,\dots ,p_k$ from a sample of X^′$X^{\prime }$s, as compared with the ideal estimator based on a random sample of Y^′$Y^{\prime }$s.     

Representing a function of two variables as a superposition over angles of ridge functions with a given shape via linear programming

A ridge function with shape function g   in the horizontal direction is a function of the form g(x)h(y,0)$g(x)h(y,0)$. Along each horizontal line it has the shape g(x)$g(x)$, multiplied by a function h(y,0)$h(y,0)$ which depends on the y-value of the horizontal line. Similarly a ridge function with shape function g   in the vertical direction has the form g(y)h(x,π/2)$g(y)h(x,\pi /2)$. For a given shape function g it may or may not be possible to represent an arbitrary   function f(x,y)$f(x,y)$ as a superposition over all angles of a ridge function with shape g   in each direction, where h=_hf=_hf,g$h=h_f=h_{f,g}$ depends on the functions f and g   and also on the direction, θ:h=_hf,g(·,θ)$\theta :h=h_{f,g}(·,\theta )$. We show that if g   is Gaussian centered at zero then this is always possible and we give the function _hf,g$h_{f,g}$ for a given f(x,y)$f(x,y)$. For highpass or for odd shapes g  , we show it is impossible to represent an arbitrary f(x,y)$f(x,y)$, i.e. in general there is no _hf,g$h_{f,g}$. Note that our problem is similar to tomography, where the problem is to invert the Radon transform, except that the use of the word inversion is here somewhat “inverted”: in tomography f(x,y)$f(x,y)$ is unknown and we find it by inverting the projections of f  ; here, f(x,y)$f(x,y)$ is known, g(z)$g(z)$ is known, and _hf(·,θ)=_hf,g(·,θ)$h_f(·,\theta )=h_{f,g}(·,\theta )$ is the unknown.     

Comparing several treatments with a control

Consider the partially balanced one-way layout for comparing k   treatments _μi,${\mu }_i,$1?i?k,$1?i?k,$ with a control _μ0${\mu }_0$. We propose a new test which is similar to the test statistics of Marcus [1976. The powers of some tests of the equality of normal means against an ordered alternative. Biometrika 63, 177–183]. By simulation we find that the proposed test has a good power performance when compared with other tests. Moreover, it can produce confidence intervals for _μi-_μ0,1?i?k.${\mu }_i-{\mu }_0,1?i?k.$