Small Area Estimation via Multivariate Fay–Herriot Models with Latent Spatial Dependence

The Fay–Herriot model is a standard model for direct survey estimators in which the true quantity of interest, the superpopulation mean, is latent and its estimation is improved through the use of auxiliary covariates. In the context of small area estimation, these estimates can be further improved by borrowing strength across spatial regions or by considering multiple outcomes simultaneously. We provide here two formulations to perform small area estimation with Fay–Herriot models that include both multivariate outcomes and latent spatial dependence. We consider two model formulations. In one of these formulations the outcome‐by‐space dependence structure is separable. The other accounts for the cross dependence through the use of a generalized multivariate conditional autoregressive (GMCAR) structure. The GMCAR model is shown, in a state‐level example, to produce smaller mean square prediction errors, relative to equivalent census variables, than the separable model and the state‐of‐the‐art multivariate model with unstructured dependence between outcomes and no spatial dependence. In addition, both the GMCAR and the separable models give smaller mean squared prediction error than the state‐of‐the‐art model when conducting small area estimation on county level data from the American Community Survey.     

Bayesian Estimators for Small Area Models when Auxiliary Information is Measured with Error

Small area estimators in linear models are typically expressed as a convex combination of direct estimators and synthetic estimators from a suitable model. When auxiliary information used in the model is measured with error, a new estimator, accounting for the measurement error in the covariates, has been proposed in the literature. Recently, for area‐level model, Ybarra & Lohr (Biometrika, 95, 2008, 919) suggested a suitable modification to the estimates of small area means based on Fay & Herriot (J. Am. Stat. Assoc., 74, 1979, 269) model where some of the covariates are measured with error. They used a frequentist approach based on the method of moments. Adopting a Bayesian approach, we propose to rewrite the measurement error model as a hierarchical model; we use improper non‐informative priors on the model parameters and show, under a mild condition, that the joint posterior distribution is proper and the marginal posterior distributions of the model parameters have finite variances. We conduct a simulation study exploring different scenarios. The Bayesian predictors we propose show smaller empirical mean squared errors than the frequentist predictors of Ybarra & Lohr (Biometrika, 95, 2008, 919), and they seem also to be more stable in terms of variability and bias. We apply the proposed methodology to two real examples.     

Calibrating the prior distribution for a normal model with conjugate prior

For a normal model with a conjugate prior, we provide an in-depth examination of the effects of the hyperparameters on the long-run frequentist properties of posterior point and interval estimates. Under an assumed sampling model for the data-generating mechanism, we examine how hyperparameter values affect the mean-squared error (MSE) of posterior means and the true coverage of credible intervals. We develop two types of hyperparameter optimality. MSE optimal hyperparameters minimize the MSE of posterior point estimates. Credible interval optimal hyperparameters result in credible intervals that have a minimum length while still retaining nominal coverage. A poor choice of hyperparameters has a worse consequence on the credible interval coverage than on the MSE of posterior point estimates. We give an example to demonstrate how our results can be used to evaluate the potential consequences of hyperparameter choices.     

A hierarchical modelling approach to combining environmental data at different scales

Summary. Long-transported air pollution in Europe is monitored by a combination of a highly complex mathematical model and a limited number of measurement stations. The model predicts deposition on a 150 km × 150 km square grid covering the whole of the continent. These predictions can be regarded as spatial averages, with some spatially correlated model error. The measurement stations give a limited number of point estimates, regarded as error free. We combine these two sources of data by assuming that both are observations of an underlying true process. This true deposition is made up of a smooth deterministic trend, due to gradual changes in emissions over space and time, and two stochastic components. One is non- stationary and correlated over long distances; the other describes variation within a grid square. Our approach is through hierarchical modelling with predictions and measurements being independent conditioned on the underlying non-stationary true deposition. We assume Gaussian processes and calculate maximum likelihood estimates through numerical optimization. We find that the variation within a grid square is by far the largest component of the variation in the true deposition. We assume that the mathematical model produces estimates of the mean over an area that is approximately equal to a grid square, and we find that it has an error that is similar to the long-range stochastic component of the true deposition, in addition to a large bias.     

Analysis of mixed outcomes: misclassified binary responses and measurement error in covariates

This paper considers regression models for mixed binary and continuous outcomes, when the true predictor is measured with error and the binary responses are subject to classification errors. The focus of the paper is to study the effects of these errors on the estimates of the model parameters and also to propose a model that incorporates both these errors. The proposed model results in a substantial improvement in the estimates as shown by extensive simulation studies.     

Bayesian Estimation of Regression Coefficients Under Extended Balanced Loss Function

Appreciating the desirability of simultaneously using both the criteria of goodness of fitted model and clustering of estimates around true parameter values, an extended version of the balanced loss function is presented and the Bayesian estimation of regression coefficients is discussed. The thus obtained optimal estimator is then compared with the least squares estimator and posterior mean vector with respect to the criteria like posterior expected loss, Bayes risk, bias vector, mean squared error matrix and risk function.     

The estimation of gross flows in the presence of measurement error using auxiliary variables

Classification error can lead to substantial biases in the estimation of gross flows from longitudinal data. We propose a method to adjust flow estimates for bias, based on fitting separate multinomial logistic models to the classification error probabilities and the true state transition probabilities using values of auxiliary variables. Our approach has the advantages that it does not require external information on misclassification rates, it permits the identification of factors that are related to misclassification and true transitions and it does not assume independence between classification errors at successive points in time. Constraining the prediction of the stocks to agree with the observed stocks protects against model misspecification. We apply the approach to data on women from the Panel Study of Income Dynamics with three categories of labour force status. The model fitted is shown to have interpretable coefficient estimates and to provide a good fit. Simulation results indicate good performance of the model in predicting the true flows and robustness against departures from the model postulated.     

Binary probability maps using a hidden conditional autoregressive Gaussian process with an application to Finnish common toad data

The Finnish common toad data of Heikkinen and Hogmander are reanalysed using an alternative fully Bayesian model that does not require a pseudolikelihood approximation and an alternative prior distribution for the true presence or absence status of toads in each 10 km×10 km square. Markov chain Monte Carlo methods are used to obtain posterior probability estimates of the square-specific presences of the common toad and these are presented as a map. The results are different from those of Heikkinen and Hogmander and we offer an explanation in terms of the prior used for square-specific presence of the toads. We suggest that our approach is more faithful to the data and avoids unnecessary confounding of effects. We demonstrate how to extend our model efficiently with square-specific covariates and illustrate this by introducing deterministic spatial changes.     

Weighted least-squares rank estimates

In this paper rank estimates, called WLS rank estimates and computed using iteratively reweighted least squares, are studied. They do not require the estimation of auxilliary scale or slope parameters nor do they require numerical search techniques to minimize a convex surface. The price is a small asymptotic efficiency loss. In the location model, beginning with a resistant starting value such as the median, the WLS rank estimates have good robustness and computational properties. The WLS rank estimate is also extended to the regression model and an example is given.     

Covariate‐adjusted borrowing of historical control data in randomized clinical trials

The borrowing of historical control data can be an efficient way to improve the treatment effect estimate of the current control group in a randomized clinical trial. When the historical and current control data are consistent, the borrowing of historical data can increase power and reduce Type I error rate. However, when these 2 sources of data are inconsistent, it may result in a combination of biased estimates, reduced power, and inflation of Type I error rate. In some situations, inconsistency between historical and current control data may be caused by a systematic variation in the measured baseline prognostic factors, which can be appropriately addressed through statistical modeling. In this paper, we propose a Bayesian hierarchical model that can incorporate patient‐level baseline covariates to enhance the appropriateness of the exchangeability assumption between current and historical control data. The performance of the proposed method is shown through simulation studies, and its application to a clinical trial design for amyotrophic lateral sclerosis is described. The proposed method is developed for scenarios involving multiple imbalanced prognostic factors and thus has meaningful implications for clinical trials evaluating new treatments for heterogeneous diseases such as amyotrophic lateral sclerosis.     

Small area estimation using unmatched sampling and linking models

The authors use a hierarchical Bayes approach to area level unmatched sampling and Unking models for small area estimation. Empirically they compare inferences under unmatched models with those obtained under the customary matched sampling and linking models. They apply the proposed method to Canadian census undercoverage estimation, developing a full hierarchical Bayes approach using Markov Chain Monte Carlo sampling methods. They show that the method can provide efficient model‐based estimates. They use posterior predictive distributions to assess model fit.     

Editorial collaborators

A simulation study of the binomial-logit model with correlated random effects is carried out based on the generalized linear mixed model (GLMM) methodology. Simulated data with various numbers of regression parameters and different values of the variance component are considered. The performance of approximate maximum likelihood (ML) and residual maximum likelihood (REML) estimators is evaluated. For a range of true parameter values, we report the average biases of estimators, the standard error of the average bias and the standard error of estimates over the simulations. In general, in terms of bias, the two methods do not show significant differences in estimating regression parameters. The REML estimation method is slightly better in reducing the bias of variance component estimates.     

Bayesian model averaging for dynamic panels with an application to a trade gravity model

We extend the Bayesian Model Averaging (BMA) framework to dynamic panel data models with endogenous regressors using a Limited Information Bayesian Model Averaging (LIBMA) methodology. Monte Carlo simulations confirm the asymptotic performance of our methodology both in BMA and selection, with high posterior inclusion probabilities for all relevant regressors, and parameter estimates very close to their true values. In addition, we illustrate the use of LIBMA by estimating a dynamic gravity model for bilateral trade. Once model uncertainty, dynamics, and endogeneity are accounted for, we find several factors that are robustly correlated with bilateral trade. We also find that applying methodologies that do not account for either dynamics or endogeneity (or both) results in different sets of robust determinants.     

Phase I trial design for drug combinations with Bayesian model averaging

Various statistical models have been proposed for two‐dimensional dose finding in drug‐combination trials. However, it is often a dilemma to decide which model to use when conducting a particular drug‐combination trial. We make a comprehensive comparison of four dose‐finding methods, and for fairness, we apply the same dose‐finding algorithm under the four model structures. Through extensive simulation studies, we compare the operating characteristics of these methods in various practical scenarios. The results show that different models may lead to different design properties and that no single model performs uniformly better in all scenarios. As a result, we propose using Bayesian model averaging to overcome the arbitrariness of the model specification and enhance the robustness of the design. We assign a discrete probability mass to each model as the prior model probability and then estimate the toxicity probabilities of combined doses in the Bayesian model averaging framework. During the trial, we adaptively allocated each new cohort of patients to the most appropriate dose combination by comparing the posterior estimates of the toxicity probabilities with the prespecified toxicity target. The simulation results demonstrate that the Bayesian model averaging approach is robust under various scenarios. Copyright © 2015 John Wiley & Sons, Ltd.     

A heteroscedastic measurement error model based on skew and heavy-tailed distributions with known error variances

In this paper, we study inference in a heteroscedastic measurement error model with known error variances. Instead of the normal distribution for the random components, we develop a model that assumes a skew-t distribution for the true covariate and a centred Student's t distribution for the error terms. The proposed model enables to accommodate skewness and heavy-tailedness in the data, while the degrees of freedom of the distributions can be different. Maximum likelihood estimates are computed via an EM-type algorithm. The behaviour of the estimators is also assessed in a simulation study. Finally, the approach is illustrated with a real data set from a methods comparison study in Analytical Chemistry.     

Bayesian adaptive dose‐escalation designs for simultaneously estimating the optimal and maximum safe dose based on safety and efficacy

The main purpose of dose‐escalation trials is to identify the dose(s) that is/are safe and efficacious for further investigations in later studies. In this paper, we introduce dose‐escalation designs that incorporate both the dose‐limiting events and dose‐limiting toxicities (DLTs) and indicative responses of efficacy into the procedure. A flexible nonparametric model is used for modelling the continuous efficacy responses while a logistic model is used for the binary DLTs. Escalation decisions are based on the combination of the probabilities of DLTs and expected efficacy through a gain function. On the basis of this setup, we then introduce 2 types of Bayesian adaptive dose‐escalation strategies. The first type of procedures, called “single objective,” aims to identify and recommend a single dose, either the maximum tolerated dose, the highest dose that is considered as safe, or the optimal dose, a safe dose that gives optimum benefit risk. The second type, called “dual objective,” aims to jointly estimate both the maximum tolerated dose and the optimal dose accurately. The recommended doses obtained under these dose‐escalation procedures provide information about the safety and efficacy profile of the novel drug to facilitate later studies. We evaluate different strategies via simulations based on an example constructed from a real trial on patients with type 2 diabetes, and the use of stopping rules is assessed. We find that the nonparametric model estimates the efficacy responses well for different underlying true shapes. The dual‐objective designs give better results in terms of identifying the 2 real target doses compared to the single‐objective designs.     

Analysis of ordered probit model with surrogate response data and measurement error in covariates

ABSTRACT

Often in data arising out of epidemiologic studies, covariates are subject to measurement error. In addition ordinal responses may be misclassified into a category that does not reflect the true state of the respondents. The goal of the present work is to develop an ordered probit model that corrects for the classification errors in ordinal responses and/or measurement error in covariates. Maximum likelihood method of estimation is used. Simulation study reveals the effect of ignoring measurement error and/or classification errors on the estimates of the regression coefficients. The methodology developed is illustrated through a numerical example.     

Robust linear discriminant analysis using S‐estimators

The authors consider a robust linear discriminant function based on high breakdown location and covariance matrix estimators. They derive influence functions for the estimators of the parameters of the discriminant function and for the associated classification error. The most B‐robust estimator is determined within the class of multivariate S‐estimators. This estimator, which minimizes the maximal influence that an outlier can have on the classification error, is also the most B‐robust location S‐estimator. A comparison of the most B‐robust estimator with the more familiar biweight S‐estimator is made.     

A comparison of estimation techniques for the three parameter pareto distribution

This paper compares minimum distance estimation with best linear unbiased estimation to determine which technique provides the most accurate estimates for location and scale parameters as applied to the three parameter Pareto distribution. Two minimum distance estimators are developed for each of the three distance measures used (Kolmogorov, Cramer‐von Mises, and Anderson‐Darling) resulting in six new estimators. For a given sample size 6 or 18 and shape parameter 1(1)4, the location and scale parameters are estimated. A Monte Carlo technique is used to generate the sample sets. The best linear unbiased estimator and the six minimum distance estimators provide parameter estimates based on each sample set. These estimates are compared using mean square error as the evaluation tool. Results show that the best linear unbaised estimator provided more accurate estimates of location and scale than did the minimum estimators tested.     

Bayesian Robustness Modelling of Location and Scale Parameters

Abstract. The modelling process in Bayesian Statistics constitutes the fundamental stage of the analysis, since depending on the chosen probability laws the inferences may vary considerably. This is particularly true when conflicts arise between two or more sources of information. For instance, inference in the presence of an outlier (which conflicts with the information provided by the other observations) can be highly dependent on the assumed sampling distribution. When heavy‐tailed (e.g. t) distributions are used, outliers may be rejected whereas this kind of robust inference is not available when we use light‐tailed (e.g. normal) distributions. A long literature has established sufficient conditions on location‐parameter models to resolve conflict in various ways. In this work, we consider a location–scale parameter structure, which is more complex than the single parameter cases because conflicts can arise between three sources of information, namely the likelihood, the prior distribution for the location parameter and the prior for the scale parameter. We establish sufficient conditions on the distributions in a location–scale model to resolve conflicts in different ways as a single observation tends to infinity. In addition, for each case, we explicitly give the limiting posterior distributions as the conflict becomes more extreme.