Logistic regression with a partially observed covariate

We present results of a Monte Carlo study comparing four methods of estimating the parameters of the logistic model logit (pr (Y = 1 | X, Z)) = α₀ + α ₁ X + α ₂ Z where X and Z are continuous covariates and X is always observed but Z is sometimes missing. The four methods examined are 1) logistic regression using complete cases, 2) logistic regression with filled-in values of Z obtained from the regression of Z on X and Y, 3) logistic regression with filled-in values of Z and random error added, and 4) maximum likelihood estimation assuming the distribution of Z given X and Y is normal. Effects of different percent missing for Z and different missing value mechanisms on the bias and mean absolute deviation of the estimators are examined for data sets of N = 200 and N = 400.     

On Censored Bivariate Random Variables: Copula,Characterization, and Estimation

Let (X, Y) be a bivariate random vector with joint distribution function F_{X, Y}(x, y) = C(F(x), G(y)), where C is a copula and F and G are marginal distributions of X and Y, respectively. Suppose that (X_i, Y_i), i = 1, 2, …, n is a random sample from (X, Y) but we are able to observe only the data consisting of those pairs (X_i, Y_i) for which X_i ? Y_i. We denote such pairs as (X*_i, Y_i*), i = 1, 2, …, ν, where ν is a random variable. The main problem of interest is to express the distribution function F_{X, Y}(x, y) and marginal distributions F and G with the distribution function of observed random variables X* and Y*. It is shown that if X and Y are exchangeable with marginal distribution function F, then F can be uniquely determined by the distributions of X* and Y*. It is also shown that if X and Y are independent and absolutely continuous, then F and G can be expressed through the distribution functions of X* and Y* and the stress–strength reliability P{X ? Y}. This allows also to estimate P{X ? Y} with the truncated observations (X*_i, Y_i*). The copula of bivariate random vector (X*, Y*) is also derived.     

CORRELATIONS AND CHARACTERIZATIONS OF THE UNIFORM DISTRIBUTION

Two characterizations of the uniform distribution on a suitable compact space are proved. These characterizations are applied to a number of particular examples of which the most interesting is the following: if X , Y and Z are independent n-vectors whose components are independent and identically distributed within a vector, then the pairwise independence of the product moment correlation coefficients between X , Y and Z implies that these vectors are normally distributed.     

Joint distribution of simultaneous exposures to several carcinogens in a case–control study: sample size determination

Consider a population of individuals who are free of a disease under study, and who are exposed simultaneously at random exposure levels, say X,Y,Z,… to several risk factors which are suspected to cause the disease in the populationm. At any specified levels X=x, Y=y, Z=z, …, the incidence rate of the disease in the population ot risk is given by the exposure–response relationship r(x,y,z,…) = P(disease|x,y,z,…). The present paper examines the relationship between the joint distribution of the exposure variables X,Y,Z, … in the population at risk and the joint distribution of the exposure variables U,V,W,… among cases under the linear and the exponential risk models. It is proven that under the exponential risk model, these two joint distributions belong to the same family of multivariate probability distributions, possibly with different parameters values. For example, if the exposure variables in the population at risk have jointly a multivariate normal distribution, so do the exposure variables among cases; if the former variables have jointly a multinomial distribution, so do the latter. More generally, it is demonstrated that if the joint distribution of the exposure variables in the population at risk belongs to the exponential family of multivariate probability distributions, so does the joint distribution of exposure variables among cases. If the epidemiologist can specify the differnce among the mean exposure levels in the case and control groups which are considered to be clinically or etiologically important in the study, the results of the present paper may be used to make sample size determinations for the case–control study, corresponding to specified protection levels, i.e., size α and 1–β of a statistical test. The multivariate normal, the multinomial, the negative multinomial and Fisher's multivariate logarithmic series exposure distributions are used to illustrate our results.     

Estimation of parameters in the singular gauss-markoff model

Consider the Gauss-Markoff model (Y, Xβ, σ² V) in the usual notation (Rao, 1973a, p. 294). If V is singular, there exists a matrix N such that N'Y has zero covariance. The minimum variance unbiased estimator of an estimable parametric function p'β is obtained in the wider class of (non-linear) unbiased estimators of the form f(N'Y) + Y'g(N'Y) where f is a scalar and g is a vector function.     

Bayesian inference in joint modelling of location and scale parameters of the t distribution for longitudinal data

This paper presents a fully Bayesian approach to multivariate t regression models whose mean vector and scale covariance matrix are modelled jointly for analyzing longitudinal data. The scale covariance structure is factorized in terms of unconstrained autoregressive and scale innovation parameters through a modified Cholesky decomposition. A computationally flexible data augmentation sampler coupled with the Metropolis-within-Gibbs scheme is developed for computing the posterior distributions of parameters. The Bayesian predictive inference for the future response vector is also investigated. The proposed methodologies are illustrated through a real example from a sleep dose–response study.     

Exponential models,brownian motion,and independence

Some examples of steep, reproductive exponential models are considered. These models are shown to possess a τ-parallel foliation in the terminology of Barndorff-Nielsen and Blaesild. The independence of certain functions follows directly from the foliation. Suppose X(t) is a Wiener process with drift where X(t) = W(t) + ct, 0 < t < T. Furthermore let Y = max [X(s), 0 < s < T]. The joint density of Y and X = X(T), the end value, is studied within the framework of an exponential model, and it is shown that Y(Y – X) is independent of X. It is further shown that Y(Y – X) suitably scaled has an exponential distribution. Further examples are considered by randomizing on T.     

An Efficient Simulation Method for the Computation of a Class of Conditional Expectations

Suppose that the random vector X and the random variable Y are jointly continuous. Also suppose that an observation x of X can be easily simulated and that the probability density function of Y conditional on X = x is known. The paper presents an efficient simulation-based algorithm for estimating E{ g ( X , Y ) | h ( X , Y ) = r } where g and h are real-valued functions. This algorithm is applicable to time series problems in which X = ( X ₁, . . . , X _n−1) and Y = X_n where { x_t } is a discrete time stochastic process for which ( X₁ , . . . , X_n ) is a continuous random vector. A numerical example from time series analysis illustrates the algorithim, for prediction for an ARCH(1) process.     

An integrated model based on statistical process control and maintenance for two-stage dependent processes

The close relationship between quality and maintenance of manufacturing systems has contributed to the development of integrated models which use the concept of statistical process control (SPC) and maintenance. This article demonstrates the integration of the Shewhart individual-residual (Z_X ? Z_e) joint control chart and maintenance for two-stage dependent processes by jointly optimizing their policies to minimize the expected total costs associated with quality, maintenance and inspection. To evaluate the effectiveness of the proposed model, two stand-alone models—a maintenance model and an SPC model—are proposed. Then a numerical example is given to illustrate the application of the proposed integrated model. The results show that the integrated model outperforms the two stand-alone models with regard to the expected cost per unit time. Finally, a sensitivity analysis is conducted to develop insights into time parameters and cost parameters that influence the integration efforts.     

Kshirsagar-Type Lower Bounds for Mean Squared Error of Prediction

Let Y be an observable random vector and Z be an unobserved random variable with joint density f(y, z | θ), where θ is an unknown parameter vector. Considering the problem of predicting Z based on Y, we derive Kshirsagar type lower bounds for the mean squared error of any predictor of Z. These bounds do not require the regularity conditions of Bhattacharyya bounds and hence are more widely applicable. Moreover, the new bounds are shown to be sharper than the corresponding Bhattacharyya bounds. The conditions for attaining the new lower bounds are useful for easy derivation of best unbiased predictors, which we illustrate with some examples.     

Least squares theory for possibly singular models

In a recent paper, Scobey (1975) observed that the usual least squares theory can be applied even when the covariance matrix σ²V of Y in the linear model Y = Xβ + e is singular by choosing the Moore-Penrose inverse (V+XX′)⁺ instead of V^-1 when V is nonsingular. This result appears to be wrong. The appropriate treatment of the problem in the singular case is described.     

ON UMP INVARIANT F-TEST PROCEDURES IN A GENERAL LINEAR MODEL

A simple method of setting linear hypotheses for a split mean vector testable by F-tests in a general linear model, when the covariance matrix has a general form and is completely unknown, is provided by extending the method discussed in Ukita et al. The critical functions in these F-tests are constructed as UMP invariants, when the covariance matrix has a known structure. Further critical functions in F-tests of linear hypotheses for the other split mean vector in the model are shown to be UMP invariant if the same known structure of the covariance matrix is assumed.     

Scale Checks in Censored Regression

Abstract. Suppose the random vector (X,Y) satisfies the regression model Y = m(X) + σ (X) ? , where m (?) and σ (?) are unknown location and scale functions and ? is independent of X. The response Y is subject to random right censoring, and the covariate X is completely observed. A new test for a specific parametric form of any scale function σ (?) (including the standard deviation function) is proposed. Its statistic is based on the distribution of the residuals obtained from the assumed regression model. Weak convergence of the corresponding process is obtained, and its finite sample behaviour is studied via simulations. Finally, characteristics of the test are illustrated in the analysis of a fatigue data set.     

Linear model estimation errors with estimated design parameters

The problem of error estimation of parameters b in a linear model,Y = Xb+ e, is considered when the elements of the design matrix X are functions of an unknown ‘design’ parameter vector c. An estimated value c is substituted in X to obtain a derived design matrix [Xtilde]. Even though the usual linear model conditions are not satisfied with [Xtilde], there are situations in physical applications where the least squares solution to the parameters is used without concern for the magnitude of the resulting error. Such a solution can suffer from serious errors.

This paper examines bias and covariance errors of such estimators. Using a first-order Taylor series expansion, we derive approximations to the bias and covariance matrix of the estimated parameters. The bias approximation is a sum of two terms:One is due to the dependence between ? and Y; the other is due to the estimation errors of ? and is proportional to b, the parameter being estimated. The covariance matrix approximation, on the other hand, is composed of three omponents:One component is due to the dependence between ? and Y; the second is the covariance matrix ∑_b corresponding to the minimum variance unbiased b, as if the design parameters were known without error; and the third is an additional component due to the errors in the design parameters. It is shown that the third error component is directly proportional to bb'. Thus, estimation of large parameters with wrong design matrix [Xtilde] will have larger errors of estimation. The results are illustrated with a simple linear example.     

Central limit theorems for functionals of large sample covariance matrix and mean vector in matrix‐variate location mixture of normal distributions

In this paper, we consider the asymptotic distributions of functionals of the sample covariance matrix and the sample mean vector obtained under the assumption that the matrix of observations has a matrix‐variate location mixture of normal distributions. The central limit theorem is derived for the product of the sample covariance matrix and the sample mean vector. Moreover, we consider the product of the inverse sample covariance matrix and the mean vector for which the central limit theorem is established as well. All results are obtained under the large‐dimensional asymptotic regime, where the dimension p and the sample size n approach infinity such that p/n→c ∈ [0, + ∞) when the sample covariance matrix does not need to be invertible and p/n→c ∈ [0,1) otherwise.     

Test of Association Between Two Ordinal Variables While Adjusting for Covariates

We propose a new set of test statistics to examine the association between two ordinal categorical variables X and Y after adjusting for continuous and/or categorical covariates Z. Our approach first fits multinomial (e.g., proportional odds) models of X and Y, separately, on Z. For each subject, we then compute the conditional distributions of X and Y given Z. If there is no relationship between X and Y after adjusting for Z, then these conditional distributions will be independent, and the observed value of (X, Y) for a subject is expected to follow the product distribution of these conditional distributions. We consider two simple ways of testing the null of conditional independence, both of which treat X and Y equally, in the sense that they do not require specifying an outcome and a predictor variable. The first approach adds these product distributions across all subjects to obtain the expected distribution of (X, Y) under the null and then contrasts it with the observed unconditional distribution of (X, Y). Our second approach computes "residuals" from the two multinomial models and then tests for correlation between these residuals; we define a new individual-level residual for models with ordinal outcomes. We present methods for computing p-values using either the empirical or asymptotic distributions of our test statistics. Through simulations, we demonstrate that our test statistics perform well in terms of power and Type I error rate when compared to proportional odds models which treat X as either a continuous or categorical predictor. We apply our methods to data from a study of visual impairment in children and to a study of cervical abnormalities in human immunodeficiency virus (HIV)-infected women. Supplemental materials for the article are available online.     

Admissible tests for the mean with additional information

Let X be a po-normal random vector with unknown µ and unknown covariance matrix ∑ and let X be partitioned as X = (X^′ ₍₁₎, …, X^′ _(r))′ where X_(j)is a subvector of X with dimension p_jsuch that ∑^r _j=1Pj = P0. Some admissible tests are derived for testing H₀: μ = 0 versus H₁: μ ¦0 based on a sample drawn from the whole vector X of dimension p and r additional samples drawn from X₍₁₎, X₍₂₎, …, X(r) respectively, All (r+1) samples are assumed to be independent. The distribution of some of the tests' statistics involved are also derived.     

On the strong Kotz approximation of Dirichlet random vectors

Let (X ₁, X ₂) be a bivariate L _p -norm generalized symmetrized Dirichlet (LpGSD) random vector with parameters α₁,α₂. If p=α₁=α₂=2, then (X ₁, X ₂) is a spherical random vector. The estimation of the conditional distribution of Z _u *:=X ₂ | X ₁>u for u large is of some interest in statistical applications. When (X ₁, X ₂) is a spherical random vector with associated random radius in the Gumbel max-domain of attraction, the distribution of Z _u * can be approximated by a Gaussian distribution. Surprisingly, the same Gaussian approximation holds also for Z _u :=X ₂| X ₁=u. In this paper, we are interested in conditional limit results in terms of convergence of the density functions considering a d-dimensional LpGSD random vector. Stating our results for the bivariate setup, we show that the density function of Z _u * and Z _u can be approximated by the density function of a Kotz type I LpGSD distribution, provided that the associated random radius has distribution function in the Gumbel max-domain of attraction. Further, we present two applications concerning the asymptotic behaviour of concomitants of order statistics of bivariate Dirichlet samples and the estimation of the conditional quantile function.