Testing for No Effect by Cosine Series Methods

The properties of three lack-of-fit tests that are related to non-parametric cosine regression analysis are examined in the context of testing for a constant mean function. Analytic power comparisons of these tests vs a most powerful test are made using intermediate asymptotic relative efficiency. In particular, a data-driven test is produced which is asymptotically as efficient as the most powerful test over a class of alternatives. A small scale simulation experiment is conducted to ascertain the extent that the large sample comparisons are applicable to finite samples.     

Generalized Log-Rank Tests for Interval-Censored Failure Time Data

Abstract.  Several non-parametric test procedures have been proposed for incomplete survival data: interval-censored failure time data. However, most of them have unknown asymptotic properties with heuristically derived and/or complicated variance estimation. This article presents a class of generalized log-rank tests for this type of survival data and establishes their asymptotics. The methods are evaluated using simulation studies and illustrated by a set of real data from a cancer study.     

A rank test for bivariate location and scale problem for elliptically symmetric populations ∗

A nonparametric rank test for the two-sample location and scale bivariate problem is proposed. The asymptotic distribution of the statistic of the test is derived under the null hypothesis and under a class of contiguous alternatives. The asymptotic relative efficiency is given and a simulation study gives the performance of the test and some competitors.     

The Two-interval Line-segment Problem

In this paper we define and study the non-parametric maximum likelihood estimator (NPMLE) in the one-dimensional line-segment problem, where we observe line-segments on the real line through an interval with a gap which is smaller than the two remaining intervals. We define the self-consistency equations for the NPMLE and provide a quick algorithm for solving them. We prove supremum norm weak convergence to a Gaussian process and efficiency of the NPMLE. The problem has a geological application in the study of the lifespan of species     

The Semiparametric Normal Variance-Mean Mixture Model

We study the normal variance-mean mixture model from a semiparametric point of view, i.e. we let the mixing distribution belong to a non-parametric family. The main results are consistency of the non-parametric maximum likelihood estimator and construction of an asymptotically normal and efficient estimator for the Euclidian part of the parameter. We study the model according to the theory outlined in the monograph by Bickel et al. (1993) and apply a general result (based on the theory of empirical processes) for semiparametric models from van der Vaart (1996) to prove asymptotic normality and efficiency of the proposed estimator.     

Non-parametric Estimation of Tail Dependence

Abstract.  Dependencies between extreme events (extremal dependencies) are attracting an increasing attention in modern risk management. In practice, the concept of tail dependence represents the current standard to describe the amount of extremal dependence. In theory, multi-variate extreme-value theory turns out to be the natural choice to model the latter dependencies. The present paper embeds tail dependence into the concept of tail copulae which describes the dependence structure in the tail of multivariate distributions but works more generally. Various non-parametric estimators for tail copulae and tail dependence are discussed, and weak convergence, asymptotic normality, and strong consistency of these estimators are shown by means of a functional delta method. Further, weak convergence of a general upper-order rank-statistics for extreme events is investigated and the relationship to tail dependence is provided. A simulation study compares the introduced estimators and two financial data sets were analysed by our methods.     

Non-proportional hazards in immuno-oncology: Is an old perspective needed?

A fundamental concept in two-arm non-parametric survival analysis is the comparison of observed versus expected numbers of events on one of the treatment arms (the choice of which arm is arbitrary), where the expectation is taken assuming that the true survival curves in the two arms are identical. This concept is at the heart of the counting-process theory that provides a rigorous basis for methods such as the log-rank test. It is natural, therefore, to maintain this perspective when extending the log-rank test to deal with non-proportional hazards, for example, by considering a weighted sum of the “observed - expected” terms, where larger weights are given to time periods where the hazard ratio is expected to favor the experimental treatment. In doing so, however, one may stumble across some rather subtle issues, related to difficulties in the interpretation of hazard ratios, that may lead to strange conclusions. An alternative approach is to view non-parametric survival comparisons as permutation tests. With this perspective, one can easily improve on the efficiency of the log-rank test, while thoroughly controlling the false positive rate. In particular, for the field of immuno-oncology, where researchers often anticipate a delayed treatment effect, sample sizes could be substantially reduced without loss of power.     

Sieve Empirical Likelihood and Extensions of the Generalized Least Squares

The empirical likelihood cannot be used directly sometimes when an infinite dimensional parameter of interest is involved. To overcome this difficulty, the sieve empirical likelihoods are introduced in this paper. Based on the sieve empirical likelihoods, a unified procedure is developed for estimation of constrained parametric or non-parametric regression models with unspecified error distributions. It shows some interesting connections with certain extensions of the generalized least squares approach. A general asymptotic theory is provided. In the parametric regression setting it is shown that under certain regularity conditions the proposed estimators are asymptotically efficient even if the restriction functions are discontinuous. In the non-parametric regression setting the convergence rate of the maximum estimator based on the sieve empirical likelihood is given. In both settings, it is shown that the estimator is adaptive for the inhomogeneity of conditional error distributions with respect to predictor, especially for heteroscedasticity.     

First hitting probabilities for semi-Markov chains and estimation

We first consider a stochastic system described by an absorbing semi-Markov chain (SMC) with finite state space, and we introduce the absorption probability to a class of recurrent states. Afterwards, we study the first hitting probability to a subset of states for an irreducible SMC. In the latter case, a non-parametric estimator for the first hitting probability is proposed and the asymptotic properties of strong consistency and asymptotic normality are proven. Finally, a numerical application on a five-state system is presented to illustrate the performance of this estimator.     

Testing for exponentiality against monotone failure rate average alternatives

We propose a test for exponentiality against the class of non-exponential distributions having monotone failure rate averages. The test statistic, which is a U-statistic and hence asymptotically normally distributed, is much simpler than its competitors yet compares favorably with them in efficiency and power comparisons.     

Semiparametric Time-Varying Coefficients Regression Model for Longitudinal Data

Abstract.  In this paper, we consider a semiparametric time-varying coefficients regression model where the influences of some covariates vary non-parametrically with time while the effects of the remaining covariates follow certain parametric functions of time. The weighted least squares type estimators for the unknown parameters of the parametric coefficient functions as well as the estimators for the non-parametric coefficient functions are developed. We show that the kernel smoothing that avoids modelling of the sampling times is asymptotically more efficient than a single nearest neighbour smoothing that depends on the estimation of the sampling model. The asymptotic optimal bandwidth is also derived. A hypothesis testing procedure is proposed to test whether some covariate effects follow certain parametric forms. Simulation studies are conducted to compare the finite sample performances of the kernel neighbourhood smoothing and the single nearest neighbour smoothing and to check the empirical sizes and powers of the proposed testing procedures. An application to a data set from an AIDS clinical trial study is provided for illustration.     

Multivariate generalizations of jonckheere's test for ordered alternatives

In many dose-response studies, each of several independent groups of animals is treated with a different dose of a substance. Many response variables are then measured on each animal. The distributions of the response variables may be nonnormal, and Jonckheere's (1954) test for ordered alternatives in the one-way layout is sometimes used to test whether the level of a single variable increases with increasing dose. In some applications, however, it is important to consider a set of response variables simultaneously. For instance, an increase in each of certain enzymes in the blood serum may suggest liver damage. To test whether these enzyme levels increase with increasing dose, it may be preferable to consider these enzymes as a group, rather than individually.

I propose two multivariate generalizations of Jonckheere's univariate test. Each multivariate test statistic is a function of coordinate-wise Jonckheere statistics—one a sum, the other a quadratic form. The sum statistic can be used to test the alternative hypothesis that each variable is stochastically increasing with increasing dose. The quadratic form statistic is designed for the more general alternative hypothesis that each variable is stochastically ordered with increasing dose.

For each of these two alternatives, I also propose a multivariate generalization of a normal theory test described by Puri (1965). I examine the asymptotic distributions of the four test statistics under the null hypothesis and under translation alternatives and compare each distribution-free test to the corresponding normal theory test in terms of asymptotic relative efficiency.

The multivariate Jonckheere tests are illustrated using does-response data from a subchronic toxicology study carried out by the National Toxicology Program. Four groups of ten male rats each were treated with increasing doses of vinylidene flouride, and the serum enzymes SDH, SGOT, and SGPT were measured. A comparison of univariate Jonckheere tests on each variable, bivariate tests on SDH and SGOT, and multivariate tests on all three variables gives insight into the behavior of the various procedures.     

On testing exponentiality against new better than used of specified age

R.M. Hollander, D.H. Park and F. Proschan [A class of life distributions for aging, J. Amer. Statist. Assoc. 81 (1986) 91–95] introduced the concept of the larger class of life distributions called new better than used of specified age. In practice, one might be interested in the new better than used behaviour at an unknown but estimable age t₀. Here, we investigate the testing of new better than used of specified age t₀ (NBU-t₀) alternatives. A class of test statistics for testing NBU-t₀ (t₀ is known) based on a U-statistic whose kernel depends on sub-sample minima is proposed. A member of the class of tests proposed by N. Ebrahimi and M. Habbibullah [Testing whether the survival distribution is new better than used of specified age, Biometrika 77 (1990) 212–215] for this problem belongs to the class of tests proposed here. The distributional properties of the class of test statistics are studied. The performances of a few members of the proposed class of tests are studied in terms of Pitman asymptotic relative efficiency. The Pitman ARE values show that the members of the class perform well in comparison with the N. Ebrahimi and M. Habbibullah [Testing whether the survival distribution is new better than used of specified age, Biometrika 77 (1990) 212–215] tests. The proposed class of tests is shown to be consistent for NBU-t₀ alternatives.     

Non-parametric Tests for the Comparison of Point Processes Based on Incomplete Data

We consider the comparison of point processes in a discrete observation situation in which each subject is observed only at discrete time points and no history information between observation times is available. A class of non-parametric test statistics for the comparison of point processes based on this kind of data is presented and their asymptotic distributions are derived. The proposed tests are generalizations of the corresponding tests for continuous observations. Some results from a simulation study for evaluating the proposed tests are presented and an illustrative example from a clinical trial is discussed.     

Repeated significance tests based on likelihood ratio statistics

For a specified decision rule, a general class of likelihood ratio based repeated significance tests is considered. An invariance principle for the likelihood ratio statistics is established and incorporated in the study of the asymptotic theory of the proposed tests. For comparing these tests with the conventional likelihood ratio tests, based solely on the target sample size, some Bahadur efficiency results are presented. The theory is then adapted in the study of some multiple comparison procedures     

SEMI-PARAMETRIC ANALYSIS OF COVARIANCE UNDER DEPENDENCE CONDITIONS WITHIN EACH GROUP

Consider the problem of covariance analysis based on regression models whose regression function is the sum of a linear and a non-parametric component. We propose a parametric and a non-parametric statistical test to compare the effects of the linear and non-parametric components, respectively, on the response variable in   L ≥ 2  groups. Serially correlated errors within each group are allowed. The first (second) test compares the differences between the estimates of the parametric (non-parametric) components of each group by means of a Mahalanobis  ( L ²)  distance. The asymptotic distribution of each statistic under the null hypothesis is obtained. A modest simulation study and an application to a real data set illustrate our methodology.     

Polynomial Spline Estimation for a Generalized Additive Coefficient Model

Abstract.  We study a semiparametric generalized additive coefficient model (GACM), in which linear predictors in the conventional generalized linear models are generalized to unknown functions depending on certain covariates, and approximate the non-parametric functions by using polynomial spline. The asymptotic expansion with optimal rates of convergence for the estimators of the non-parametric part is established. Semiparametric generalized likelihood ratio test is also proposed to check if a non-parametric coefficient can be simplified as a parametric one. A conditional bootstrap version is suggested to approximate the distribution of the test under the null hypothesis. Extensive Monte Carlo simulation studies are conducted to examine the finite sample performance of the proposed methods. We further apply the proposed model and methods to a data set from a human visceral Leishmaniasis study conducted in Brazil from 1994 to 1997. Numerical results outperform the traditional generalized linear model and the proposed GACM is preferable.     

Asymptotic optimality of a class of rank tests for replicated latin-square designs

This paper is concerned with the class of conditionally distribution-free rank tests introduced by Monga and Tardif (1994) for replicated Latin-square designs. It is possible to proceed with an enlargement of this class by making use of the method of ranking after substitution. The unconditional asymptotic behaviour of any member of the enlarged class is derived under the null hypothesis of no treatment effects as well as under a sequence of contiguous alternatives. This enables the establishment of the asymptotic Pitman efficiency of any member relative to the asymptotically minimax test and to conclude that at least one member of the class is asymptotically as efficient as the latter.     

Weighted combinations of rank tests for location-scale alternatives

All existing location-scale rank tests use equal weights for the components. We advocate the use of weighted combinations of statistics. This approach can partly be substantiated by the theory of locally most powerful tests. We specifically investi= gate a Wilcoxon-Mood combination. We give exact critical values for a range of weights. The asymptotic normality of the test statistic is proved under a general hypothesis and Chernoff-Savage conditions. The asymptotic relative efficiency of this test with respect to unweighted combinations shows that a careful choice of weights results in a gain in efficiency.     

Testing for ordered alternatives by combining independent distribution-free block statistics

A class of distribution-free tests for ordered alternatives in a block design is presented. On each block a distribution-free statistic is selected, and a weighted sum of these statistics is then formed. A procedure for selecting the weighting constants which maximize the asymptotic relative efficiency is presented. The improvement in the efficiency of the weighted sum of block statistics over the unweighted sum is considered and proves interesting. Some attention is also given to the idea of using different types of statistics on different blocks.