Estimation and goodness-of-fit for the Cox model with various types of censored data

The currently existing estimation methods and goodness-of-fit tests for the Cox model mainly deal with right censored data, but they do not have direct extension to other complicated types of censored data, such as doubly censored data, interval censored data, partly interval-censored data, bivariate right censored data, etc. In this article, we apply the empirical likelihood approach to the Cox model with complete sample, derive the semiparametric maximum likelihood estimators (SPMLE) for the Cox regression parameter and the baseline distribution function, and establish the asymptotic consistency of the SPMLE. Via the functional plug-in method, these results are extended in a unified approach to doubly censored data, partly interval-censored data, and bivariate data under univariate or bivariate right censoring. For these types of censored data mentioned, the estimation procedures developed here naturally lead to Kolmogorov-Smirnov goodness-of-fit tests for the Cox model. Some simulation results are presented.     

Fisher information in censored samples from Downton's bivariate exponential distribution

We develop a simple approach to finding the Fisher information matrix (FIM) for a single pair of order statistic and its concomitant, and Type II right, left, and doubly censored samples from an arbitrary bivariate distribution. We use it to determine explicit expressions for the FIM for the three parameters of Downton's bivariate exponential distribution for single pairs and Type II censored samples. We evaluate the FIM in censored samples for finite sample sizes and determine its limiting form as the sample size increases. We discuss implications of our findings to inference and experimental design using small and large censored samples and for ranked-set samples from this distribution.     

Bivariate negative binomial regression model with excess zeros and right censoring: an application to Indonesian data

We propose a bivariate hurdle negative binomial (BHNB) regression model with right censoring to model correlated bivariate count data with excess zeros and few extreme observations. The parameters of the BHNB regression model are obtained using maximum likelihood with conjugate gradient optimization. The proposed model is applied to actual survey data where the bivariate outcome is number of days missed from primary activities and number of days spent in bed due to illness during the 4-week period preceding the inquiry date. We compared the right censored BHNB model to the right censored bivariate negative binomial (BNB) model. A simulation study is conducted to discuss some properties of the BHNB model. Our proposed model demonstrated superior performance in goodness-of-fit of estimated frequencies.KEYWORDS: Zero inflation, over-dispersion, parameter estimation, model selection, right censoring     

Estimation of the bivariate distribution function for censored gap times

In many medical studies, patients may experience several events during follow-up. The times between consecutive events (gap times) are often of interest and lead to problems that have received much attention recently. In this work, we consider the estimation of the bivariate distribution function for censored gap times. Some related problems such as the estimation of the marginal distribution of the second gap time and the conditional distribution are also discussed. In this article, we introduce a nonparametric estimator of the bivariate distribution function based on Bayes’ theorem and Kaplan–Meier survival function and explore the behavior of the four estimators through simulations. Real data illustration is included.     

An inverse-probability-weighted approach to estimation of the bivariate survival function under left-truncation and right-censoring

In this note, we consider estimating the bivariate survival function when both survival times are subject to random left truncation and one of the survival times is subject to random right censoring. Motivated by Satten and Datta [2001. The Kaplan–Meier estimator as an inverse-probability-of-censoring weighted average. Amer. Statist. 55, 207–210], we propose an inverse-probability-weighted (IPW) estimator. It involves simultaneous estimation of the bivariate survival function of the truncation variables and that of the censoring variable and the truncation variable of the uncensored components. We prove that (i) when there is no censoring, the IPW estimator reduces to NPMLE of van der Laan [1996a. Nonparametric estimation of the bivariate survival function with truncated data. J. Multivariate Anal. 58, 107–131] and (ii) when there is random left truncation and right censoring on only one of the components and the other component is always observed, the IPW estimator reduces to the estimator of Gijbels and Gürler [1998. Covariance function of a bivariate distribution function estimator for left truncated and right censored data. Statist. Sin. 1219–1232]. Based on Theorem 3.1 of van der Laan [1996a. Nonparametric estimation of the bivariate survival function with truncated data. J. Multivariate Anal. 58, 107–131, 1996b. Efficient estimation of the bivariate censoring model and repairing NPMLE. Ann. Statist. 24, 596–627], we prove that the IPW estimator is consistent under certain conditions. Finally, we examine the finite sample performance of the IPW estimator in some simulation studies. For the special case that censoring time is independent of truncation time, a simulation study is conducted to compare the performances of the IPW estimator against that of the estimator proposed by van der Laan [1996a. Nonparametric estimation of the bivariate survival function with truncated data. J. Multivariate Anal. 58, 107–131, 1996b. Efficient estimation of the bivariate censoring model and repairing NPMLE. Ann. Statist. 24, 596–627]. For the special case (i), a simulation study is conducted to compare the performances of the IPW estimator against that of the estimator proposed by Huang et al. (2001. Nonnparametric estimation of marginal distributions under bivariate truncation with application to testing for age-of-onset application. Statist. Sin. 11, 1047–1068).     

Estimation of parameter of Morgenstern type bivariate exponential distribution using concomitants of order statistics

In this paper we have considered concomitants of order statistics arising from Morgenstern type bivariate exponential distribution and their applications in estimating the unknown parameter involved in the distribution. We have obtained the best linear unbiased estimator of a parameter involved in Morgenstern type bivariate exponential distribution using both complete and censored samples.     

On the computing of the moments of bivariate order statistics

In this paper, we establish general recurrence relations satisfied by the product moments (of any order) of bivariate order statistics from any arbitrary bivariate uniform distribution function. Moreover, we present formulae to easily compute the product moments (of any order) of bivariate order statistics from any arbitrary bivariate distribution function, with positive left endpoints, or with negative right endpoints.     

On cramér-von mises tests of goodness of fit with censored data

The paper considers the goodness of fit tests with right censored data or doubly censored data. The Fredholm Integral Equation (FIE) method proposed by Ren (1993) is implemented in the simulation studies to estimate the null distribution of the Cramér-von Mises test statistics and the asymptotic covariance function of the self-consistent estimator for the lifetime distribution with right censored data or doubly censored data. We show that for fixed alternatives, the bootstrap method does not estimate the null distribution consistently for doubly censored data. For the right censored case, a comparison between the performance of FIE and the η out of η bootstrap shows that FIE gives better estimation for the null distribution. The application of FIE to a set of right censored Channing House data and to a set of doubly censored breast cancer data is presented.     

Cumulative Incidence Association Models for Bivariate Competing Risks Data

Association models, like frailty and copula models, are frequently used to analyze clustered survival data and evaluate within-cluster associations. The assumption of noninformative censoring is commonly applied to these models, though it may not be true in many situations. In this paper, we consider bivariate competing risk data and focus on association models specified for the bivariate cumulative incidence function (CIF), a nonparametrically identifiable quantity. Copula models are proposed which relate the bivariate CIF to its corresponding univariate CIFs, similarly to independently right censored data, and accommodate frailty models for the bivariate CIF. Two estimating equations are developed to estimate the association parameter, permitting the univariate CIFs to be estimated either parametrically or nonparametrically. Goodness-of-fit tests are presented for formally evaluating the parametric models. Both estimators perform well with moderate sample sizes in simulation studies. The practical use of the methodology is illustrated in an analysis of dementia associations.     

Estimation on dependent right censoring scheme in an ordinary bivariate geometric distribution

Discrete lifetime data are very common in engineering and medical researches. In many cases the lifetime is censored at a random or predetermined time and we do not know the complete survival time. There are many situations that the lifetime variable could be dependent on the time of censoring. In this paper we propose the dependent right censoring scheme in discrete setup when the lifetime and censoring variables have a bivariate geometric distribution. We obtain the maximum likelihood estimators of the unknown parameters with their risks in closed forms. The Bayes estimators as well as the constrained Bayes estimates of the unknown parameters under the squared error loss function are also obtained. We considered an extension to the case where covariates are present along with the data. Finally we provided a simulation study and an illustrative example with a real data.     

Maximum likelihood estimation of Burr XII distribution parameters under random censoring

In this paper, we consider the maximum likelihood estimation of the parameters of Burr XII distribution using randomly right censored data. We provide necessary and sufficient conditions for the existence and uniqueness of the maximum likelihood estimates. Under such conditions, it is shown that the maximum likelihood estimates are strongly consistent for the true values of the parameters and are asymptotically bivariate normal. An application to leukemia free-survival times for allogeneic and autologous transplant patients is given.     

Basu–Dhar bivariate geometric distribution in the presence of covariates and censored data: a Bayesian approach

In this paper, we introduce classical and Bayesian approaches for the Basu–Dhar bivariate geometric distribution in the presence of covariates and censored data. This distribution is considered for the analysis of bivariate lifetime as an alternative to some existing bivariate lifetime distributions assuming continuous lifetimes as the Block and Basu or Marshall and Olkin bivariate distributions. Maximum likelihood and Bayesian estimators are presented. Two examples are considered to illustrate the proposed methodology: an example with simulated data and an example with medical bivariate lifetime data.     

Small sample comparison of six bivariate survival curve estimators 1

We study the performance of six proposed bivariate survival curve estimators on simulated right censored data. The performance of the estimators is compared for data generated by three bivariate models with exponential marginal distributions. The estimators are compared in their ability to estimate correlations and survival functions probabilities. Simulated data results are presented so that the proposed estimators in this relatively new area of analysis can be explicitly compared to the known distribution of the data and the parameters of the underlying model. The results show clear differences in the performance of the estimators.     

Some inference results in bivariate exponential distributions rased on censored samples

In this paper, two bivariate exponential distributions based on time(right) censored samples are presented. We assume that the censoring time is independent of the life-times of the two components. This paper obtains comparison of different tests for testing zero and non-zero values of the parameter λ₃ which measures the degree of

dependence between the two components and also testing symmetry of the two components or λ₁=λ₂ in

the bivariate exponential distribution (BVED) formulated by Marshall and Olkin (1967) based on the above censored sample. It is observed from simulated study that the test based on MLE's performs better in both tests of independence as well as symmetry. The above results have been extended also in Block and Basu (19874) model.     

Cure rate model with bivariate interval censored data

A mixture model is proposed to analyze a bivariate interval censored data with cure rates. There exist two types of association related with bivariate failure times and bivariate cure rates, respectively. A correlation coefficient is adopted for the association of bivariate cure rates and a copula function is applied for bivariate survival times. The conditional expectation of unknown quantities attributable to interval censored data and cure rates are calculated in the E-step in ES (Expectation-Solving algorithm) and the marginal estimates and the association measures are estimated in the S-step through a two-stage procedure. A simulation study is performed to evaluate the suggested method and a real data from HIV patients is analyzed as a real data example.     

Tests for bivaroate exponentiality against bifra alternatives based on censored samples

We develop a test procedure to test the hypothesis that the distribution of the lifetime is bivariate exponential of Marshall and Olkin against that it is bivariate increasing failure rate average when the sample is of the type univariate or bivariate randomly censored.     

More on progressively Type‐II censored order statistics for multivariate observations

In this paper, we consider some results on distribution theory of multivariate progressively Type‐II censored order statistics. We also establish some characterizations of Freund's bivariate exponential distribution based on the lack of memory property.     

The estimation of treatment effect for the censored bivariate data under the univariate censoring

This paper establishes a nonparametric estimator for the treatment effect on censored bivariate data under unvariate censoring. This proposed estimator is based on the one from Lin and Ying(1993)'s nonparametric bivariate survival function estimator, which is itself a generalized version of Park and Park(1995)' quantile estimator. A Bahadur type representation of quantile functions were obtained from the marginal survival distribution estimator of Lin and Ying' model. The asymptotic property of this estimator is shown below and the simulation studies are also given     

Empirical likelihood inference for the bivariate survival function under univariate censoring

In this article, we apply the empirical likelihood method to make inference on the bivariate survival function of paired failure times by estimating the survival function of censored time with the Kaplan–Meier estimator. Adjusted empirical likelihood (AEL) confidence intervals for the bivariate survival function are developed. We conduct a simulation study to compare the proposed AEL method with other methods. The simulation study shows the proposed AEL method has better performance than other existing methods. We illustrate the proposed method by analyzing the skin graft data.     

Erratum to “Progressively Type-II right censored order statistics from discrete distributions” [J. Statist. Plann. Inference 138 (2008) 845–856]

In this note, we correct the proof of Representation 1 of Balakrishnan and Dembińska [2008. Progressively Type-II right censored order statistics from discrete distributions. J. Statist. Plann. Inference 138, 845–856] which relates the joint distribution of progressively Type-II right censored order statistics corresponding to an arbitrary population to progressively Type-II right censored order statistics from the standard uniform distribution.