Quantile-adaptive variable screening in ultra-high dimensional varying coefficient models

The varying-coefficient model is an important nonparametric statistical model since it allows appreciable flexibility on the structure of fitted model. For ultra-high dimensional heterogeneous data it is very necessary to examine how the effects of covariates vary with exposure variables at different quantile level of interest. In this paper, we extended the marginal screening methods to examine and select variables by ranking a measure of nonparametric marginal contributions of each covariate given the exposure variable. Spline approximations are employed to model marginal effects and select the set of active variables in quantile-adaptive framework. This ensures the sure screening property in quantile-adaptive varying-coefficient model. Numerical studies demonstrate that the proposed procedure works well for heteroscedastic data.     

The Performance of Two Data-Generation Processes for Data with Specified Marginal Treatment Odds Ratios

Monte Carlo simulation methods are increasingly being used to evaluate the property of statistical estimators in a variety of settings. The utility of these methods depends upon the existence of an appropriate data-generating process. Observational studies are increasingly being used to estimate the effects of exposures and interventions on outcomes. Conventional regression models allow for the estimation of conditional or adjusted estimates of treatment effects. There is an increasing interest in statistical methods for estimating marginal or average treatment effects. However, in many settings, conditional treatment effects can differ from marginal treatment effects. Therefore, existing data-generating processes for conditional treatment effects are of little use in assessing the performance of methods for estimating marginal treatment effects. In the current study, we describe and evaluate the performance of two different data-generation processes for generating data with a specified marginal odds ratio. The first process is based upon computing Taylor Series expansions of the probabilities of success for treated and untreated subjects. The expansions are then integrated over the distribution of the random variables to determine the marginal probabilities of success for treated and untreated subjects. The second process is based upon an iterative process of evaluating marginal odds ratios using Monte Carlo integration. The second method was found to be computationally simpler and to have superior performance compared to the first method.     

Distributional aspects in latent variable models

For observable indicators with ordered categories one can assume underlying latent variables following certain marginal distributions. Transforming the latent variables changes its marginal distributions but not the observable qualitative indicators. The joint distribution of the latent variables can be constructed from the marginal distributions. There is a broad class of multivariate distributions for which the observable indicators are equivalent. By choosing the multivariate normal distribution from this class we can analyse a linear relationship between the transformed latent variables. This leads to latent structural equation models. Estimation of these latter models is therefore more general than the distributional assumption might initially suggest. Robustness of the estimation procedure is also discussed for deviations from this distribution family. Using ordinal business survey data of the German Ifo-institute we test the efficiency of firms' price expectations implied by the rational expectation hypothesis.     

Monte Carlo approximation of likelihood function in spatial GLMMs through an empirical Bayes method

In spatial generalized linear mixed models (SGLMMs), statistical inference encounters problems, since random effects in the model imply high-dimensional integrals to calculate the marginal likelihood function. In this article, we temporarily treat parameters as random variables and express the marginal likelihood function as a posterior expectation. Hence, the marginal likelihood function is approximated using the obtained samples from the posterior density of the latent variables and parameters given the data. However, in this setting, misspecification of prior distribution of correlation function parameter and problems associated with convergence of Markov chain Monte Carlo (MCMC) methods could have an unpleasant influence on the likelihood approximation. To avoid these challenges, we utilize an empirical Bayes approach to estimate prior hyperparameters. We also use a computationally efficient hybrid algorithm by combining inverse Bayes formula (IBF) and Gibbs sampler procedures. A simulation study is conducted to assess the performance of our method. Finally, we illustrate the method applying a dataset of standard penetration test of soil in an area in south of Iran.     

Graphs for Margins of Bayesian Networks

Directed acyclic graph (DAG) models—also called Bayesian networks—are widely used in probabilistic reasoning, machine learning and causal inference. If latent variables are present, then the set of possible marginal distributions over the remaining (observed) variables is generally not represented by any DAG. Larger classes of mixed graphical models have been introduced to overcome this; however, as we show, these classes are not sufficiently rich to capture all the marginal models that can arise. We introduce a new class of hyper‐graphs, called mDAGs, and a latent projection operation to obtain an mDAG from the margin of a DAG. We show that each distinct marginal of a DAG model is represented by at least one mDAG and provide graphical results towards characterizing equivalence of these models. Finally, we show that mDAGs correctly capture the marginal structure of causally interpreted DAGs under interventions on the observed variables.     

Monte-Carlo Sensitivity Analysis for Controlled Direct Effects Using Marginal Structural Models in the Presence of Confounded Mediators

In randomized trials, investigators are frequently interested in estimating the direct effect of a treatment on an outcome that is not relayed by intermediate variables, in addition to the usual intention-to-treat (ITT) effect. Even if the ITT effect is not confounded due to randomization, the direct effect is not identified when unmeasured variables affect the intermediate and outcome variables. Although the unmeasured variables cannot be adjusted for in the models, it is still important to evaluate the potential bias of these variables quantitatively. This article proposes a sensitivity analysis method for controlled direct effects using a marginal structural model that is an extension of the sensitivity analysis method of unmeasured confounding introduced in the context of observational studies. The proposed method is illustrated using a randomized trial of depression.     

Estimation of bivariate and marginal distributions with censored data

Summary. Consider a pair of random variables, both subject to random right censoring. New estimators for the bivariate and marginal distributions of these variables are proposed. The estimators of the marginal distributions are not the marginals of the corresponding estimator of the bivariate distribution. Both estimators require estimation of the conditional distribution when the conditioning variable is subject to censoring. Such a method of estimation is proposed. The weak convergence of the estimators proposed is obtained. A small simulation study suggests that the estimators of the marginal and bivariate distributions perform well relatively to respectively the Kaplan–Meier estimator for the marginal distribution and the estimators of Pruitt and van der Laan for the bivariate distribution. The use of the estimators in practice is illustrated by the analysis of a data set.     

Statistical Inference for the Multidimensional Mixed Rasch Model

Inference in generalized linear mixed models with multivariate random effects is often made cumbersome by the high-dimensional intractable integrals involved in the marginal likelihood. This article presents an inferential methodology based on the GEE approach. This method involves the approximations of the marginal likelihood and joint moments of the variables. It is also proposed an approximate Akaike and Bayesian information criterions based on the approximate marginal likelihood using the estimation of the parameters by the GEE approach. The different results are illustrated with a simulation study and with an analysis of real data from health-related quality of life.     

Relative Price Changes and Inequality in the Size Distribution of Various Components of Income

This article uses a comprehensive model of economic inequality to examine the impact of relative price changes on inequality in the marginal distributions of various income components in which the marginal distributions are derived from a multidimensional joint distribution. The multidimensional joint distribution function is assumed to be a member of the Pearson Type VI family; that is, it is assumed to be a beta distribution of the second kind. The multidimensional joint distribution is so called because it is a joint distribution of components of income and expenditures on various commodity groups. Gini measures of inequality are devised from the marginal distributions of the various income components. The inequality measures are shown to depend on the parameters of the multidimensional joint distribution. It is then shown that the parameters of the multidimensional joint distribution depend on the relative prices of various commodity groups and several other specified exogenous variables. Thus, knowledge of how changes in relative prices affect the parameters of the multidimensional joint distribution is deductively equivalent to knowledge of how changes in relative prices affect inequality in the marginal distributions of various components of income. It is found that relative price changes have a statistically significant impact on inequality in various components of income.     

Structural inference of the parameters of the heteroscedastic simultaneous equation model

The structural approach of inference for the parameters of a simultaneous equation model with heteroscedastic error variance is investigated in this paper. The joint and the marginal structural distributions for the coefficients of the exogenous variables and the scale parameters of the error variables, and the marginal likelihood function of the coefficients of the endogenous variables have been derived. The estimates are directly obtainable from the structural distribution and the marginal likelihood function of the parameters. The marginal distribution of a subset of coefficients of exogenous variables provides the basis for making inference for a particular subset of parameter of interest.     

Forward irrelevance

We investigate how to combine marginal assessments about the values that random variables assume separately into a model for the values that they assume jointly, when (i) these marginal assessments are modelled by means of coherent lower previsions and (ii) we have the additional assumption that the random variables are forward epistemically irrelevant to each other. We consider and provide arguments for two possible combinations, namely the forward irrelevant natural extension and the forward irrelevant product, and we study the relationships between them. Our treatment also uncovers an interesting connection between the behavioural theory of coherent lower previsions, and Shafer and Vovk's game-theoretic approach to probability theory.     

Average Collapsibility of Distribution Dependence and Quantile Regression Coefficients

Abstract. The Yule–Simpson paradox notes that an association between random variables can be reversed when averaged over a background variable. Cox and Wermuth introduced the concept of distribution dependence between two random variables X and Y, and gave two dependence conditions, each of which guarantees that reversal of qualitatively similar conditional dependences cannot occur after marginalizing over the background variable. Ma, Xie and Geng studied the uniform collapsibility of distribution dependence over a background variable W, under stronger homogeneity condition. Collapsibility ensures that associations are the same for conditional and marginal models. In this article, we use the notion of average collapsibility, which requires only the conditional effects average over the background variable to the corresponding marginal effect and investigate its conditions for distribution dependence and for quantile regression coefficients.     

Detecting structural change in linear models

Consider a sequence of independent observations which change their marginal distribution at most once somewhere in the sequence and one is not certain where the change has occurred. One would be interested in detecting the change and determining the two distributions which would describe the sequence. On the other hand if no change had occurred, one would want to know the common distribution of the observations. This study develops a Bayesian test for detecting a switch from one linear model to another. The test is based on the marginal posterior mass function of the switch point and the posterior probability of a stable model. This test and an informal sequential procedure of Smith are illustrated with data generated from an unstable linear regression model, which changes the linear relationship between the dependent and independent variables     

A generalized bivariate Bernoulli model with covariate dependence

Dependence in outcome variables may pose formidable difficulty in analyzing data in longitudinal studies. In the past, most of the studies made attempts to address this problem using the marginal models. However, using the marginal models alone, it is difficult to specify the measures of dependence in outcomes due to association between outcomes as well as between outcomes and explanatory variables. In this paper, a generalized approach is demonstrated using both the conditional and marginal models. This model uses link functions to test for dependence in outcome variables. The estimation and test procedures are illustrated with an application to the mobility index data from the Health and Retirement Survey and also simulations are performed for correlated binary data generated from the bivariate Bernoulli distributions. The results indicate the usefulness of the proposed method.     

A Note on DRHR Preservation Property of Generalized Order Statistics

In this paper we study some problems associated with count data from a bivariate Poisson distribution, in which the marginal means are functions of explanatory variables. The estimates of these regression coefficients are developed under a variety of conditions: unrestricted linear model; parallelism of the regression planes; the coincidence of the regression planes. Tests are also developed for the validity of hypotheses involved in these models. The techniques are illustrated using simulated data.     

A note on optimal vector unbiased predictor

A characterization of optimal vector unbiased predictor is obtained. Some properties of optimal unbiased predictors are established. It is shown that simultaneous prediction of future random variables is equivalent to marginal prediction of these random variables. Following Kale and Chandrasekar (1983) and Chandrasekar (1984), it is shown that the criteria proposed by ishii (1969) based on matrices and the one proposed by Bibby and Toutenburg (1977) based on quadratic loss in the class of vector unbiased predictors are equivalent. The above approach is illustrated with some examples.     

Simultaneous inference in structured additive conditional copula regression models: a unifying Bayesian approach

While most regression models focus on explaining distributional aspects of one single response variable alone, interest in modern statistical applications has recently shifted towards simultaneously studying multiple response variables as well as their dependence structure. A particularly useful tool for pursuing such an analysis are copula-based regression models since they enable the separation of the marginal response distributions and the dependence structure summarised in a specific copula model. However, so far copula-based regression models have mostly been relying on two-step approaches where the marginal distributions are determined first whereas the copula structure is studied in a second step after plugging in the estimated marginal distributions. Moreover, the parameters of the copula are mostly treated as a constant not related to covariates and most regression specifications for the marginals are restricted to purely linear predictors. We therefore propose simultaneous Bayesian inference for both the marginal distributions and the copula using computationally efficient Markov chain Monte Carlo simulation techniques. In addition, we replace the commonly used linear predictor by a generic structured additive predictor comprising for example nonlinear effects of continuous covariates, spatial effects or random effects and furthermore allow to make the copula parameters covariate-dependent. To facilitate Bayesian inference, we construct proposal densities for a Metropolis–Hastings algorithm relying on quadratic approximations to the full conditionals of regression coefficients avoiding manual tuning. The performance of the resulting Bayesian estimates is evaluated in simulations comparing our approach with penalised likelihood inference, studying the choice of a specific copula model based on the deviance information criterion, and comparing a simultaneous approach with a two-step procedure. Furthermore, the flexibility of Bayesian conditional copula regression models is illustrated in two applications on childhood undernutrition and macroecology.     

Rank correlation plots for use with correlated input variables

A method for inducing a desired rank correlation matrix on multivariate input vectors for simulation studies has recently been developed by Iman and Conover (1982). The primary intention of this procedure is to produce correlated input variables for use with computer models. Since this procedure is distribution free and allows the exact marginal distributions to remain intact it can be used with any marginal distributions for which it is reasonable to think in terms of correlation. In this paper we present a series of rank correlation plots based on this procedure when the marginal distributions are normal, lognormal, uniform and loguniform. These plots provide a convenient tool both for aiding the modeler in determining the degree of dependence among input variables (rather than guessing) and for communicating with the modeler the effect of different correlation assumptions. In addition this procedure can be used with sample multivariate data by sampling directly from the respective marginal empirical distribution functions.     

Consistent variable selection via the optimal discovery procedure in multiple testing

In this paper, we translate variable selection for linear regression into multiple testing, and select significant variables according to testing result. New variable selection procedures are proposed based on the optimal discovery procedure (ODP) in multiple testing. Due to ODP’s optimality, if we guarantee the number of significant variables included, it will include less non significant variables than marginal p-value based methods. Consistency of our procedures is obtained in theory and simulation. Simulation results suggest that procedures based on multiple testing have improvement over procedures based on selection criteria, and our new procedures have better performance than marginal p-value based procedures.     

A hybrid approach to achieving both marginal and conditional balances for stratification variables in sequential clinical trials

Various methods exist in the literature for achieving marginal balance for baseline stratification variables in sequential clinical trials. One major limitation with balancing on the margins of the stratification variables is that there is an efficiency loss when the primary analysis is stratified. To preserve the efficiency of a stratified analysis one recently proposed approach balances on the crossing of the stratification variables included in the analysis, which achieves conditional balance for the variables. A hybrid approach to achieving both marginal and conditional balances in sequential clinical trials is proposed, which is applicable to both continuous and categorical stratification variables. Numerical results based on extensive simulation studies and a real dataset show that the proposed approach outperforms the existing ones and is particularly useful when both additive and stratified models are planned for a trial. Copyright © 2013 John Wiley & Sons, Ltd.