Hybrid Bayesian inference on HIV viral dynamic models

Modelling of HIV dynamics in AIDS research has greatly improved our understanding of the pathogenesis of HIV-1 infection and guided for the treatment of AIDS patients and evaluation of antiretroviral therapies. Some of the model parameters may have practical meanings with prior knowledge available, but others might not have prior knowledge. Incorporating priors can improve the statistical inference. Although there have been extensive Bayesian and frequentist estimation methods for the viral dynamic models, little work has been done on making simultaneous inference about the Bayesian and frequentist parameters. In this article, we propose a hybrid Bayesian inference approach for viral dynamic nonlinear mixed-effects models using the Bayesian frequentist hybrid theory developed in Yuan [Bayesian frequentist hybrid inference, Ann. Statist. 37 (2009), pp. 2458–2501]. Compared with frequentist inference in a real example and two simulation examples, the hybrid Bayesian approach is able to improve the inference accuracy without compromising the computational load.     

Default Bayesian analysis of the Behrens–Fisher problem

In the Bayesian approach, the Behrens–Fisher problem has been posed as one of estimation for the difference of two means. No Bayesian solution to the Behrens–Fisher testing problem has yet been given due, perhaps, to the fact that the conventional priors used are improper. While default Bayesian analysis can be carried out for estimation purposes, it poses difficulties for testing problems. This paper generates sensible intrinsic and fractional prior distributions for the Behrens–Fisher testing problem from the improper priors commonly used for estimation. It allows us to compute the Bayes factor to compare the null and the alternative hypotheses. This default procedure of model selection is compared with a frequentist test and the Bayesian information criterion. We find discrepancy in the sense that frequentist and Bayesian information criterion reject the null hypothesis for data, that the Bayes factor for intrinsic or fractional priors do not.     

Bayesian–frequentist hybrid model with application to the analysis of gene copy number changes

Gene copy number (GCN) changes are common characteristics of many genetic diseases. Comparative genomic hybridization (CGH) is a new technology widely used today to screen the GCN changes in mutant cells with high resolution genome-wide. Statistical methods for analyzing such CGH data have been evolving. Existing methods are either frequentist's or full Bayesian. The former often has computational advantage, while the latter can incorporate prior information into the model, but could be misleading when one does not have sound prior information. In an attempt to take full advantages of both approaches, we develop a Bayesian-frequentist hybrid approach, in which a subset of the model parameters is inferred by the Bayesian method, while the rest parameters by the frequentist's. This new hybrid approach provides advantages over those of the Bayesian or frequentist's method used alone. This is especially the case when sound prior information is available on part of the parameters, and the sample size is relatively small. Spatial dependence and false discovery rate are also discussed, and the parameter estimation is efficient. As an illustration, we used the proposed hybrid approach to analyze a real CGH data.     

A Bayesian inference of P(λ1<λ2) for two Poisson parameters

The statistical inference drawn from the difference between two independent Poisson parameters is often discussed in the medical literature. However, such discussions are usually based on the frequentist viewpoint rather than the Bayesian viewpoint. Here, we propose an index θ=P(λ_{1, post}<λ_{2, post}), where λ_{1, post} and λ_{2, post} denote Poisson parameters following posterior density. We provide an exact and an approximate expression for calculating θ using the conjugate gamma prior and compare the probabilities obtained using the approximate and the exact expressions. Moreover, we also show a relation between θ and the p-value. We also highlight the significance of θ by applying it to the result of actual clinical trials. Our findings suggest that θ may provide useful information in a clinical trial.     

A matching prior based on the modified profile likelihood in a generalized Weibull stress‐strength model

Bayesian inference of a generalized Weibull stress‐strength model (SSM) with more than one strength component is considered. For this problem, properly assigning priors for the reliabilities is challenging due to the presence of nuisance parameters. Matching priors, which are priors matching the posterior probabilities of certain regions with their frequentist coverage probabilities, are commonly used but difficult to derive in this problem. Instead, we apply an alternative method and derive a matching prior based on a modification of the profile likelihood. Simulation studies show that this proposed prior performs well in terms of frequentist coverage and estimation even when the sample sizes are minimal. The prior is applied to two real datasets. The Canadian Journal of Statistics 41: 83–97; 2013 © 2012 Statistical Society of Canada     

Statistical inference for the Gompertz distribution based on Type-II progressively hybrid censored data

In this article, the statistical inference for the Gompertz distribution based on Type-II progressively hybrid censored data is discussed. The estimation of the parameters for Gompertz distribution is obtained using maximum likelihood method (MLE) and Bayesian method under three different loss functions. We also proved the existence and uniqueness of the MLE. The one-sample Bayesian prediction intervals are obtained. The work is done for different values of the parameters. We apply the Monto Carlo simulation to compare the proposed methods, also an example is discussed to construct the Prediction intervals.     

A Bayesian approach for analysing longitudinal nominal outcomes using random coefficients transitional generalized logit model: an application to the labour force survey data

A random-effects transition model is proposed to model the economic activity status of household members. This model is introduced to take into account two kinds of correlations; one due to the longitudinal nature of the study, which will be considered using a transition parameter, and the other due to the existing correlation between responses of members of the same household which is taken into account by introducing random coefficients into the model. The results are presented based on the homogeneous (all parameters are not changed by time) and non-homogeneous Markov models with random coefficients. A Bayesian approach via the Gibbs sampling is used to perform parameter estimation. Results of using random-effects transition model are compared, using deviance information criterion, with those of three other models which exclude random effects and/or transition effects. It is shown that the full model gains more precision due to the consideration of all aspects of the process which generated the data. To illustrate the utility of the proposed model, a longitudinal data set which is extracted from the Iranian Labour Force Survey is analysed to explore the simultaneous effect of some covariates on the current economic activity as a nominal response. Also, some sensitivity analyses are performed to assess the robustness of the posterior estimation of the transition parameters to the perturbations of the prior parameters.     

A bayesian analysis of the intraclass correlations in the mixed linear model

This article is concerned with the study of intraclass correlations in the mixed linear model. A brief account of the shortcomings of the existing meth¬ods (frequentist. likelihood and Bayesian) is followed by alternative Bayesian parametrizations involving intraclass correlations and variance ratios. Our prior specifications accommodate a priori dependencies as well as situations which involve little or no prior information. We give examples of interval estimation and hypothesis testing using data from an animal breeding study.     

Estimation,prediction and interpretation of NGG random effects models: an application to Kevlar fibre failure times

We propose a class of Bayesian semiparametric mixed-effects models; its distinctive feature is the randomness of the grouping of observations, which can be inferred from the data. The model can be viewed under a more natural perspective, as a Bayesian semiparametric regression model on the log-scale; hence, in the original scale, the error is a mixture of Weibull densities mixed on both parameters by a normalized generalized gamma random measure, encompassing the Dirichlet process. As an estimate of the posterior distribution of the clustering of the random-effects parameters, we consider the partition minimizing the posterior expectation of a suitable class of loss functions. As a merely illustrative application of our model we consider a Kevlar fibre lifetime dataset (with censoring). We implement an MCMC scheme, obtaining posterior credibility intervals for the predictive distributions and for the quantiles of the failure times under different stress levels. Compared to a previous parametric Bayesian analysis, we obtain narrower credibility intervals and a better fit to the data. We found that there are three main clusters among the random-effects parameters, in accordance with previous frequentist analysis.     

Bayesian Estimation of the Parameters of Bivariate Exponential Distributions

In this article, we develop an empirical Bayesian approach for the Bayesian estimation of parameters in four bivariate exponential (BVE) distributions. We have opted for gamma distribution as a prior for the parameters of the model in which the hyper parameters have been estimated based on the method of moments and maximum likelihood estimates (MLEs). A simulation study was conducted to compute empirical Bayesian estimates of the parameters and their standard errors. We use moment estimators or MLEs to estimate the hyper parameters of the prior distributions. Furthermore, we compare the posterior mode of parameters obtained by different prior distributions and the Bayesian estimates based on gamma priors are very close to the true values as compared to improper priors. We use MCMC method to obtain the posterior mean and compared the same using the improper priors and the classical estimates, MLEs.     

On Variational Bayes Estimation and Variational Information Criteria for Linear Regression Models

Variational Bayes (VB) estimation is a fast alternative to Markov Chain Monte Carlo for performing approximate Baesian inference. This procedure can be an efficient and effective means of analyzing large datasets. However, VB estimation is often criticised, typically on empirical grounds, for being unable to produce valid statistical inferences. In this article we refute this criticism for one of the simplest models where Bayesian inference is not analytically tractable, that is, the Bayesian linear model (for a particular choice of priors). We prove that under mild regularity conditions, VB based estimators enjoy some desirable frequentist properties such as consistency and can be used to obtain asymptotically valid standard errors. In addition to these results we introduce two VB information criteria: the variational Akaike information criterion and the variational Bayesian information criterion. We show that variational Akaike information criterion is asymptotically equivalent to the frequentist Akaike information criterion and that the variational Bayesian information criterion is first order equivalent to the Bayesian information criterion in linear regression. These results motivate the potential use of the variational information criteria for more complex models. We support our theoretical results with numerical examples.     

The Bayesian and frequentist approaches to testing a one-sided hypothesis about a multivariate mean

This paper compares the Bayesian and frequentist approaches to testing a one-sided hypothesis about a multivariate mean. First, this paper proposes a simple way to assign a Bayesian posterior probability to one-sided hypotheses about a multivariate mean. The approach is to use (almost) the exact posterior probability under the assumption that the data has multivariate normal distribution, under either a conjugate prior in large samples or under a vague Jeffreys prior. This is also approximately the Bayesian posterior probability of the hypothesis based on a suitably flat Dirichlet process prior over an unknown distribution generating the data. Then, the Bayesian approach and a frequentist approach to testing the one-sided hypothesis are compared, with results that show a major difference between Bayesian reasoning and frequentist reasoning. The Bayesian posterior probability can be substantially smaller than the frequentist p-value. A class of example is given where the Bayesian posterior probability is basically 0, while the frequentist p-value is basically 1. The Bayesian posterior probability in these examples seems to be more reasonable. Other drawbacks of the frequentist p-value as a measure of whether the one-sided hypothesis is true are also discussed.     

Bayesian analysis of the generalized gamma distribution using non-informative priors

The Generalized gamma (GG) distribution plays an important role in statistical analysis. For this distribution, we derive non-informative priors using formal rules, such as Jeffreys prior, maximal data information prior and reference priors. We have shown that these most popular formal rules with natural ordering of parameters, lead to priors with improper posteriors. This problem is overcome by considering a prior averaging approach discussed in Berger et al. [Overall objective priors. Bayesian Analysis. 2015;10(1):189–221]. The obtained hybrid Jeffreys-reference prior is invariant under one-to-one transformations and yields a proper posterior distribution. We obtained good frequentist properties of the proposed prior using a detailed simulation study. Finally, an analysis of the maximum annual discharge of the river Rhine at Lobith is presented.     

Statistical inference based on generalized Lindley record values

This paper addresses the problems of frequentist and Bayesian estimation for the unknown parameters of generalized Lindley distribution based on lower record values. We first derive the exact explicit expressions for the single and product moments of lower record values, and then use these results to compute the means, variances and covariance between two lower record values. We next obtain the maximum likelihood estimators and associated asymptotic confidence intervals. Furthermore, we obtain Bayes estimators under the assumption of gamma priors on both the shape and the scale parameters of the generalized Lindley distribution, and associated the highest posterior density interval estimates. The Bayesian estimation is studied with respect to both symmetric (squared error) and asymmetric (linear-exponential (LINEX)) loss functions. Finally, we compute Bayesian predictive estimates and predictive interval estimates for the future record values. To illustrate the findings, one real data set is analyzed, and Monte Carlo simulations are performed to compare the performances of the proposed methods of estimation and prediction.     

A matching prior for extreme quantile estimation of the generalized Pareto distribution

Extreme quantile estimation plays an important role in risk management and environmental statistics among other applications. A popular method is the peaks-over-threshold (POT) model that approximate the distribution of excesses over a high threshold through generalized Pareto distribution (GPD). Motivated by a practical financial risk management problem, we look for an appropriate prior choice for Bayesian estimation of the GPD parameters that results in better quantile estimation. Specifically, we propose a noninformative matching prior for the parameters of a GPD so that a specific quantile of the Bayesian predictive distribution matches the true quantile in the sense of Datta et al. (2000).     

Bayes/frequentist compromise decision rules for Gaussian sampling

Bayesian methods have the potential to confer substantial advantages over frequentist when the assumed prior is approximately correct, but otherwise can perform poorly. Therefore, estimators and other inferences that strike a compromise between Bayes and frequentist optimality are attractive. To evaluate potential trade-offs, we study Bayes vs. frequentist risk under Gaussian sampling for families of point estimators and interval estimators. Bayes/frequentist compromises for interval estimation are more challenging than for point estimation, since performance involves an interplay between coverage and length. Each family allows ‘purchasing’ improved frequentist performance by allowing a small increase in Bayes risk over the Bayes rule. Any degree of increase can be specified, thus enabling greater or lesser trade-offs between Bayes and frequentist risk.     

Generalized Control Charts for Non-Normal Data Using g-and-k Distributions

Statistical control charts are often used in industry to monitor processes in the interests of quality improvement. Such charts assume independence and normality of the control statistic, but these assumptions are often violated in practice. To better capture the true shape of the underlying distribution of the control statistic, we utilize the g-and-k distributions to estimate probability limits, the true ARL, and the error in confidence that arises from incorrectly assuming normality. A sensitivity assessment reveals that the extent of error in confidence associated with control chart decision-making procedures increases more rapidly as the distribution becomes more skewed or as the tails of the distribution become longer than those of the normal distribution. These methods are illustrated using both a frequentist and computational Bayesian approach to estimate the g-and-k parameters in two different practical applications. The Bayesian approach is appealing because it can account for prior knowledge in the estimation procedure and yields posterior distributions of parameters of interest such as control limits.     

A new bivariate exponential distribution for modeling moderately negative dependence

This paper introduces a new bivariate exponential distribution, called the Bivariate Affine-Linear Exponential distribution, to model moderately negative dependent data. The construction and characteristics of the proposed bivariate distribution are presented along with estimation procedures for the model parameters based on maximum likelihood and objective Bayesian analysis. We derive Jeffreys prior and discuss its frequentist properties based on a simulation study and MCMC sampling techniques. A real data set of mercury concentration in largemouth bass from Florida lakes is used to illustrate the methodology.     

Generalized fiducial inference for generalized exponential distribution

This article mainly considers interval estimation of the scale and shape parameters of the generalized exponential (GE) distribution. We adopt the generalized fiducial method to construct a kind of new confidence intervals for the parameters of interest and compare them with the frequentist and Bayesian methods. In addition, we give the comparison of the point estimation based on the frequentist, generalized fiducial and Bayesian methods. Simulation results show that a new procedure based on generalized fiducial inference is more applicable than the non-fiducial methods for the point and interval estimation of the GE distribution. Finally, two lifetime data sets are used to illustrate the application of our new procedure.