Effects of resistance training on liver structure and function of aged rats

The aging process may cause negative physiological changes. However, exercises as resistance training (RT) have been considered an important intervention to attenuate these changes. Additionally, liver plays an important role in blood glucose homeostasis in exercise.

Aim: This study aimed to analyze the effects of RT on the liver components of aged animals.

Methods: Male Wistar rats were divided into two groups: 24 months’ group (CONTROL); and group submitted to a progressive RT protocol for 16 weeks (EXERCISE). Both groups were sacrificed at 24 months.

Results: We observed a decrease in blood flow due to the practice of resistance exercises. Besides, our results showed that hepatic tissue plays an important role in glycemic homeostasis during RT. In addition, RT increased mitogen capacity of hepatocytes.

Conclusions: Our study showed many implications for the knowledge about the effects of strength training on old animals’ liver.     

Effect of warning placement on the information processing of college students reading an OTC drug facts panel

Objective: To compare three over-the-counter (OTC) Drug Facts panel versions for information processing optimization among college students.

Participants: University of Houston students (N = 210) participated in a cross-sectional survey from January to May 2010.

Methods: A current FDA label was compared to two experimental labels developed using the theory of CHREST to test information processing by re-positioning the warning information within the Drug Facts panel. Congruency was defined as placing like information together. Information processing was evaluated using the OTC medication Label Evaluation Process Model (LEPM): label comprehension, ease-of-use, attitude toward the product, product evaluation, and purchase intention.

Results: Experimental label with chunked congruent information (uses-directions-other information-warnings) was rated significantly higher than the current FDA label and had the best average scores among the LEPM information processing variables.

Conclusion: If replications uphold these findings, the FDA label design might be revised to improve information processing.     

Grandiose and vulnerable narcissism: Associations with alcohol use,alcohol problems and problem recognition

Objective: This study fills a gap in the literature by examining the relationship between two types of narcissism, vulnerable and grandiose, and five alcohol-related outcomes (ie, alcohol use, alcohol problems, evaluation and expectancies of problems, and readiness to change).

Participants: 345 college students (28% men, 72% women) from a Midwestern university were recruited from undergraduate psychology courses from April 2015 to October 2016.

Methods: Participants completed an online survey with questionnaires measuring the variables of interest. Multiple regression analyses were used to test the hypotheses.

Results: Grandiose narcissism was a positive predictor of alcohol consumption and a positive (ie, good) evaluation of alcohol-related problems. Vulnerable narcissism was a positive predictor of alcohol-related problems, problem recognition (ie, readiness to change), and problem expectancies.

Conclusions: The results speak to the effects that different types of narcissism have on alcohol use, alcohol problems and attitudes towards alcohol problems among young adults.     

Heart checks in college-aged students link poor sleep to cardiovascular risk

Objective: To describe the relationships between the cardiovascular health, lifestyle behaviors, and lifestyle beliefs among college-aged students.

Participants: Seven hundred and twenty-nine college-aged students participated between October 2016 and April 2017.

Methods: Heart checks, consisting of a cross-sectional survey and biometric screening, were conducted on a large Midwestern university campus.

Results: A small proportion of students (24.5%) engaged in the recommended 150+ minutes of physical activity per week and 7.9% consumed 5+ servings of fruit/vegetables daily. Half (49.6%) slept 7 hours or less per night. Biometric screenings found that 26.4% of the students had high stress, 31.9% were overweight or obese, and 17.3% had prehypertension or hypertension. Less sleep was significantly associated with higher risks of being stressed, being overweight/obese, and having elevated blood pressure.

Conclusions: Early detection, treatment, and education is critical to identify individuals at risk for cardiovascular disease and to promote healthy lifestyle changes before heart disease develops or progresses.     

A Web-based review of sexual and reproductive health services available at colleges and universities in Georgia

Objective: Although two-thirds of graduating high school seniors attend college or university in the U.S., there is a paucity of national or state specific research regarding SRH services available on or near college and university campuses.

Methods: A review of websites for all colleges and universities in Georgia was conducted to evaluate sexual health services available on campuses and evidence of referral to community providers.

Results: Of 96 colleges in Georgia, 44 had campus-located health centers, with only 3 at two-year colleges. Overall SRH service provision was low, with great variation between colleges. Distances between colleges and Title X clinics ranged from 0.33 to 35.45 miles.

Conclusions: Many students lack access to campus health centers, and information on college websites regarding SRH service availability and referrals differs dramatically between campuses. In the absence of robust campus-located services, schools should highlight where students can obtain comprehensive SRH care in the community.     

A meta-analysis of effectiveness of E-interventions to reduce alcohol consumption in college and university students.

Objective: To evaluate the effectiveness and moderators of E-Interventions versus assessment only (AO) controls in the reduction of alcoholic drinks per week (DPW) in university students.

Study design and methods: Cochrane library, CINAEL, ERIC, MEDLINE, PsycINFO, PubMed, and Web of Science were searched up to June 2017. Studies were included if they were: an RCT, assessed the effectiveness of E-Interventions at reducing DPW, and employed university/college students. 23 studies (N = 7,614) were included and quality was assessed using the JADAD scale.

Results: Weighted mean effect sizes were calculated using random-effects models. These showed a small, significant effect of E-Interventions at reducing the number of alcoholic DPW. Moderator analysis found a significant advantage for web-based personalised feedback interventions compared to other E-Interventions.

Conclusions: E-Interventions show a small, significant effect at reducing mean alcoholic DPW. Personalised feedback E-Interventions showed the strongest effect.     

Measuring characteristics of e-cigarette consumption among college students

Objective: E-cigarette use among college students has increased drastically in recent years. This study aims to inform development of a comprehensive measure of e-cigarette consumption for this population.

Participants and Methods: This mixed-method study collected both quantitative and qualitative data from a sample of 43 experienced e-cigarette users from two college campuses, using a self-reported questionnaire and a semi-structured interview, in March–September of 2017.

Results: College student users found some of the consumption questions in national surveys difficult to answer. Switching nicotine levels, mixing flavors, co-using with alcohol and marijuana, using with others who were vaping or drinking, and vaping in a car or indoor space were all common. The participants defined “regular user” based on ownership of a device rather than on quantity/frequency.

Conclusions: A comprehensive e-cigarette consumption measure should cover the complex characteristics that are potentially associated with negative health consequences such as flavorings, co-use and social contexts.     

Worry and rumination: Explanatory roles in the relation between pain and anxiety and depressive symptoms among college students with pain

Objective: Pain affects a significant proportion of college students in the United States and has been linked to anxiety and depressive symptoms. Rumination and worry, two transdiagnostic factors linked to comorbidity, may explain the relationship between pain and mental health symptoms.

Current Study: The current study examined worry and rumination as explanatory factors in the relationship between pain and anxiety and depressive symptoms in a sample of college students with pain (n?=?1,577; 79.9% female).

Results: Results indicated that both rumination and worry explained the relationship between pain and depressive and social anxiety symptoms, while rumination alone explained the relationship between pain and anxious arousal symptoms.

Conclusion: The current study provides novel empirical evidence that worry and rumination each help explain the relationship between pain and anxiety and depressive symptoms among college students with current pain, and college students in pain may benefit from targeted psychosocial strategies aimed at decreasing worry and ruminative responses.     

Inverse association of testosterone and sex hormone binding globulin levels with leukocyte count in middle-aged and elderly men

Objective: The inverse associations of testosterone and sex hormone-binding globulin (SHBG) levels with cardiometabolic diseases are well established and are increasingly viewed as inflammatory diseases. This study aimed to examine the associations of testosterone and SHBG levels with leukocyte count in 451 Korean men aged ≥50 years.

Methods: Serum testosterone and SHBG levels were categorized into tertiles. High leukocyte count was defined as ≥7340 cells/μl, which corresponded to the 75th percentile of the current sample. The odds ratios (ORs) and 95% confidence intervals (95% CIs) for high leukocyte count were calculated across testosterone and SHBG tertiles using multiple logistic regression analysis.

Results: The mean leukocyte counts significantly decreased with increasing testosterone and SHBG tertiles. The ORs (95% CIs) of high leukocyte count for the first tertile of testosterone and SHBG were 3.27 (1.34–7.95) and 2.38 (1.05–5.96), respectively, compared with the referent third tertile, after adjusting for age, smoking status, alcohol drinking, regular exercise, body mass index, blood pressure, fasting plasma glucose, triglyceride, and high-density lipoprotein (HDL) cholesterol level.

Conclusion: We found inversely graded associations of low testosterone and SHBG levels with leukocyte count. These findings suggest that low testosterone and SHBG levels may be interpreted as a state of low-grade inflammation.     

The feasibility of goal attainment scaling to measure case resolution in elder abuse and neglect adult protective services intervention

Objectives: This pilot study describes implementation procedures of goal attainment scaling (GAS) and examines the feasibility of using GAS to measure the multifarious intervention outcome of case resolution in elder mistreatment (EM) adult protective services (APS).

Methods: Substantiated EM victims (n = 27) were recruited prospectively from the State of Maine APS. An adapted GAS approach was implemented involving development of a pre-populated goal scale menu and web-based GAS application.

Results: The GAS menu comprised 18 goals and corresponding scales spanning several domains of case resolution: social support, service access, health/functioning, enhancing independence, and protective measures. The overall GAS process had mean length 33.8 min per case. The mean GAS summary t-score (54.3) aligned with theoretical expectations.

Discussion: Without a measure of case resolution, research cannot compare the effectiveness of different EM intervention models. Findings suggest that GAS is a feasible, client-centered strategy to measure the multifarious EM intervention case resolution outcome.     

Prostate-specific antigen decline pattern in advanced prostate cancer receiving androgen deprivation therapy and relationship with prostate-specific antigen progression

Introduction: The aim of this study is to evaluate prostate-specific antigen decline pattern including prostate-specific antigen kinetics following androgen deprivation therapy on prostate-specific antigen progression in the patients with advanced prostate cancer.

Materials and methods: Ninety-seven advanced prostate cancer patients receiving maximum androgen deprivation therapy were enrolled in case–control study. Baseline prostate-specific antigen, Gleason Score, bone metastase, nadir prostate-specific antigen, time to nadir prostate-specific antigen, declining slope to nadir prostate-specific antigen, estimated baseline prostate-specific antigen half-time, current prostate-specific antigen, post-nadir prostate-specific antigen time, estimated prostate-specific antigen, estimated decline of baseline prostate-specific antigen as quantitative, and ratio were recorded and calculated.

Results: The ratio of prostate-specific antigen progression was significantly lower at the patients who had slower declining slope to prostate-specific antigen, longer time to nadir prostate-specific antigen, and lower estimated decline ratio of baseline prostate-specific antigen (p: .016, p: .020, and p: .026, respectively).

Conclusions: The shorter time to nadir prostate-specific antigen following androgen deprivation therapy, faster declining slope to nadir prostate-specific antigen and higher estimated decline ratio of baseline prostate-specific antigen are associated with higher risk of disease progression in patients with hormone-sensitive prostate cancer.     

A longitudinal analysis of the relationships among daytime dysfunction,fatigue, and depression in college students

Objective: To examine the longitudinal trajectory of daytime dysfunction (DD) and its relationship with fatigue by depression status in university students.

Participants: 243 students completed online surveys from September- December 2016.

Methods: Surveys were conducted at three time points over a semester period: the beginning of the semester, the end of mid-term and the end of the semester.

Results: Results indicated that the DD significantly increased in all students over the semester. Students with depression showed a higher initial level of DD and faster rate of change compared to those without depression. A faster rate of change of DD predicted a higher level of end-semester fatigue.

Conclusions: Depression is related to a higher initial level of DD and its faster rate change which in turn, predicted end-semester fatigue, identifying one of the possible pathways through which depression impacts the functioning and health of affected students.     

Complete blood count parameters in peripheral arterial disease

Objective: To determine whether complete blood count parameters could be used as the biomarkers of inflammation in patients with in peripheral arterial disease.

Methods: Seventy-five patients with peripheral arterial disease (study group) and 75 healthy subjects (control group) were included in this retrospective study. Their baseline clinical characteristics and laboratory data were recorded and compared. Data were compared using univariate tests including independent samples t-test, Mann–Whitney U-test and chi-square test. Moreover, multivariate logistic regression analysis was also conducted to determine independent predictors of peripheral arterial disease.

Results: The groups were statistically similar with regards to baseline clinical and demographic features. The values of C-reactive protein, white blood cell and neutrophil-to-lymphocyte ratio values were found to be statistically significantly higher in study group versus control group, but none of them were considered as an independent predictor of peripheral arterial disease according to multivariate logistic regression analysis. Only mean platelet volume was demonstrated to be a statistically significant predictor of peripheral arterial disease.

Conclusion: Our study deduced that mean platelet volume was an independent predictor of peripheral arterial disease, and could be used as a marker of inflammation in patients with peripheral arterial disease.     

Gene expression of insulin receptor,insulin-like growth factor increases and insulin-like growth factor-binding protein-3 reduces with increase in prostate size in benign prostatic hyperplasia

Introduction: Although the role of insulin in the development of benign prostatic hyperplasia (BPH) is well established, there are no studies regarding alteration in the gene expression of components of insulin-signaling pathway and their association with prostate size in BPH. Hence, the study was designed to analyze the gene and protein expression of insulin receptor and its related components in patients with BPH.

Materials and methods: Twenty-seven BPH patients aged between 55 and 75 years were recruited in the study and prostatic tissues were obtained after transurethral resection of the prostate. Gene expression levels of Insulin receptor (IR), insulin receptor substrate (IRS), insulin-like growth factor (IGF) and insulin-like growth factor-binding protein-3 (IGFBP-3) were assessed by q-PCR.

Results: Insulin receptor (IR-A and B) and insulin-like growth factors (IGF-1 and IGF-2) gene expression were significantly increased and IGFBP-3 gene expression was reduced in BPH patients with larger prostate size. Also, serum insulin was significantly increased and IGFBP-3 was significantly reduced in patients with larger prostate size.

Conclusion: Increased expression of IR-A, B and IGF-1, 2 genes and reduced IGFBP-3 gene expression was associated with larger prostate size in BPH.     

Childhood Victimization,Cognitive Schemas,and Unwanted Consensual Sex Among College Students

Objective: Unwanted consensual sex (UCS)—freely consenting to sex that is neither wanted nor desired—is largely excluded from campus programming and the literature on sexual behavior. The present study expands on previous research to examine the relation between childhood victimization experiences and UCS.

Methods: Data were gathered using an online survey of college students.

Results: In the past year, 43% percent of 587 college students who engaged in sexual activity also engaged in UCS at least once. Childhood victimization was modestly related to frequency of UCS. The relation between childhood victimization and UCS was mediated by disconnection/rejection schemas (e.g., beliefs that one’s needs will not be met by others).

Conclusions: Results suggest that altering cognitive schemas through evidence-based psychotherapy may interrupt the relation between childhood victimization and engagement in UCS.     

Pilot testing the detection of elder abuse through emergency care technicians (DETECT) screening tool: results from the DETECT pilot project

Objective: To pilot test the feasibility of implementing an elder abuse (EA) screening tool (DETECT) designed for medics.

Methods: Testing occurred between September 17th, 2015 and October 26th, 2015. MedStar Mobile Healthcare medics completed the DETECT tool when responding to calls for community-dwelling patients 65 years of age or older.

Results: The DETECT tool was used 1,248 times by 97% of medics responding to an eligible 911 call. Medics responded affirmatively to at least one screening item on 209 of the completed screenings (16.8%). Immediately following the introduction of the DETECT tool, there was an increase of 5.4 (226% above baseline) reports per month (p = 0.0056).

Conclusions: The DETECT tool was easily incorporated into medic’s field-based practice and resulted in an increase in medic generated reports of EA to APS. Future research designed to evaluate the tool’s validity and reliability are warranted.     

Life after loss: Comparing student service member/veteran and civilian mental health characteristics among individuals exposed to death by suicide

Objective: This study evaluated the mental health characteristics and beliefs of student service members/veterans (SSM/Vs) who have been exposed to another’s death by suicide.

Participants: A total of 39 SSM/Vs exposed to suicide and 32 SSM/Vs not exposed to suicide were sampled from a larger, epidemiological survey. An age- and gender-matched group of 39 civilian (C) students was drawn from a larger sample of individuals exposed to suicide.

Methods: Data were collected as part of an Internet-based, campus needs survey that occurred in Fall 2014. Participants were asked to complete measures about suicide-related behaviors, suicide prevention, help-seeking, and demographics.

Results: SSM/Vs exposed to suicide had more positive mental health/suicide prevention beliefs than SSM/Vs not exposed to suicide. Cs exposed to suicide were not significantly different from either group. Unique help-seeking patterns were also identified.

Conclusions: The current study identifies unique characteristics of SSM/Vs exposed to suicide that may inform prevention programming.     

Intergenerational Programs Review: Study Design and Characteristics of Intervention,Outcomes, and Effectiveness

There is a growing interest in intergenerational connectivity through intergenerational programs. In this work, a review of intergenerational programs was performed, with focus on the program design and objectives as well as in their outcomes.

We used a systematic review method in which we screened 3,796 articles. After analyzing titles, abstracts, and full paper analysis, 16 articles were retained. Each study was reviewed, and data were extracted related to target population, study design, characteristics of intervention, outcomes, and effectiveness.

Intergenerational programs included educational programs and art, Information technology development, cultural heritage, health education, and therapeutic activities. Most of the programs collected both quantitative and/or qualitative data. Seven studies collected data in the beginning and at the end of the program. Significant diversity in sample size and intervention length was found. Measurement of outcomes was performed in both young and/or elderly group of participants. Programs impact evaluation varied between studies, including validated scales, interviews, observation, focus groups, and conversation analysis, narratives, videotaped sessions, and field notes.

Our study highlighted the diversity in the design of studies and in the program’s effectiveness evaluation. More randomized design studies are required to support researchers and practitioners in the development of future intergenerational programs.     

Trends in cardiovascular diseases and associated risks in sub-Saharan Africa: a review of the evidence for Ghana,Nigeria, South Africa,Sudan and Tanzania

Background: Sub-Saharan Africa (SSA) countries are facing an epidemiological shift from infectious disease to chronic diseases, such as cardiovascular diseases (CVDs). CVDs incidence in SSA are frequently attributed to the prevalence of hypertension, diabetes, and overweight/obesity. Nevertheless, some researchers contend that CVDs are not a priority public health problem in SSA.

Method: This paper systematically reviews the evidence on CVDs and their relation with hypertension, diabetes mellitus and obesity/overweight in Ghana, Nigeria, South Africa, Sudan and Tanzania. The publication’s content was analyzed qualitatively using the directed content analysis method and the results were presented in a tabular format.

Result: The paper illustrates the rising prevalence of CVDs as well as the three related risk conditions in the selected SSA countries.

Conclusion: The review indicates a poor health system response to the increasing risk of CVDs in SSA. The conditions and major drivers that contribute to this underlying increasing trend need to be further studied.