Statistical testing strategies for assessing treatment efficacy and marker accuracy in phase III trials

When a candidate predictive marker is available, but evidence on its predictive ability is not sufficiently reliable, all‐comers trials with marker stratification are frequently conducted. We propose a framework for planning and evaluating prospective testing strategies in confirmatory, phase III marker‐stratified clinical trials based on a natural assumption on heterogeneity of treatment effects across marker‐defined subpopulations, where weak rather than strong control is permitted for multiple population tests. For phase III marker‐stratified trials, it is expected that treatment efficacy is established in a particular patient population, possibly in a marker‐defined subpopulation, and that the marker accuracy is assessed when the marker is used to restrict the indication or labelling of the treatment to a marker‐based subpopulation, ie, assessment of the clinical validity of the marker. In this paper, we develop statistical testing strategies based on criteria that are explicitly designated to the marker assessment, including those examining treatment effects in marker‐negative patients. As existing and developed statistical testing strategies can assert treatment efficacy for either the overall patient population or the marker‐positive subpopulation, we also develop criteria for evaluating the operating characteristics of the statistical testing strategies based on the probabilities of asserting treatment efficacy across marker subpopulations. Numerical evaluations to compare the statistical testing strategies based on the developed criteria are provided.     

Becoming Custodial Dads: Exploring Parenting Among Low‐Income and Working‐Class African American Fathers

The authors use an ecological framework and grounded theoretical analysis to explore the circumstances in which working‐class and low‐income custodial African American fathers gain custody of their children, their transition from part‐time to full‐time parents, and the role of support networks in enhancing or inhibiting these men's parenting. Twenty‐four men from an impoverished Midwestern urban area participated in the study. The findings suggest that these men, and perhaps others sharing their demographic profiles, generally become parents by default and are often reluctant to take on a full‐time, single parenting role. Adaptation to the role seems to be enhanced by these men's use of extended kin support networks and shared living arrangements. However, low wages, a lack of sufficient assistance from public assistance programs, and informal custody arrangements often inhibit their fathering.     

在位相空间中求解外力含时的受迫量子谐振子

运用广义线性量子变换理论 ,在位相空间中通过算子的代数运算求解外力含时的受迫谐振子 ,给出了演化算子、演化算子矩阵元和波函数的表示式 .     

我国高校文科学报的“当代化”论

高校文科学报的“当代化”是相对于时下盛行的“现代化”而言的。它是根据我国高校文科学报的发生及其发展历程的阶段性特征 ,以及“当代化”所蕴涵的人类文明进程的阶段性定位和“与时俱进”的时代性体现的科学内涵而提出来的。“当代化”具有现实性和求真性的鲜明特征 ,对于 2 1世纪我国高校文科学报的发展是一种求真务实的选择。     

高性能可重构DSP处理器的数据通路设计

介绍了高性能定点可重构DSP处理器的数据通路设计。该数据通路以功能强大的16位定点计算单元为基础,搭建起高速16位数据处理平台;并能以单指令流多数据流的方式灵活支持多维向量运算;通过重构的方法有效地支持了32位数据处理。     

律师在侦查阶段的诉讼地位和作用

律师在侦查阶段介入刑事诉讼不享有辩护人的独立诉讼地位 ,其法律行为具有法律帮助性质 ,主要为犯罪嫌疑人提供法律咨询 ,代理申诉、控告和为犯罪嫌疑人申请取保候审等。这种界定不仅有利于明确律师在侦查阶段的职责 ,也有利于打消认为律师介入侦查将带来太多负效应的顾虑。     

论资本市场全球一体化趋势

资本市场全球一体化是当前全球资本市场发展的基本趋势。是指相对独立的全球各主要资本市场日益融合形成的统一市场网络组织结构体系。表现为市场组织形式的全球网络化 ;筹资主体的国际化 ;投资者的机构化及投资活动的国际化 ;资本流动的全球化 ;同质的金融资产价格趋同化 ;金融机构经营业务的混业化和全球化。资本市场全球一体化降低了市场主体的交易成本 ,提高了市场效率 ;为一些国家调节国际收支失衡与国际储备的保值增值提供了便利条件 ;有利于长期资本的优化配置 ,促进世界经济增长。同时也使各国运用货币政策调控宏观经济的有效性降低 ;市场的系统性风险增大 ;金融监管面临新的挑战     

ERP在钢铁贸易企业的应用研究

以上海宝钢技术经济发展公司为对象,根据公司对提升内部管理及业务流程规范化的要求,研究了公司建立ERP系统的定位及目标,提出应建立以钢材贸易和钢铁产品深加工为主业的ERP体系,实现流通过程中的价值增值.在分析存在的主要问题的基础上,提出了ERP的模式、流程设计及采购业务、库存业务的解决方案.     

ispLSI1016在数字锁相环中的应用

讨论了采用ispLSI1 0 1 6构造数字锁相环的基本方法 ,并给出了分频器、相位比较器和吞脉冲计数器的相应的编码指令     

无抵触理论与我国公共英语教学

将无抵触理论应用于公共英语教学，可以对外语学习活动进行设计，使学习者水平与任务的难度相当、培养语言学习兴趣、加强师生交流、确保学习者获得学习主动权等，使其在学习过程中体验到巨大乐趣，进入以注意力高度集中和全身心投入为特征的无抵触心理状态，提高学习效率。