Effects of tadalafil treatment combined with physical activity in patients with low onset hypogonadism: results from a not-randomized single arm phase 2 study

Purpose: To investigate a possible relation between penile Doppler ultrasound examination (PDUE) parameters and efficacy of chronic therapy with tadalafil (TAD) combined with a protocol of aerobic physical activity (PA) in patients with late onset hypogonadism (LOH). Methods: The study evaluated 30 patients consecutively enrolled with LOH and erectile dysfunction which present contraindication to hormonal replacement therapy for concomitant prostate disease. These patients were subjected to a combined protocol with phosphodiesterase V selective inhibitors (TAD 5?mg daily) and aerobic PA.

Results: After three months, we observed significant improvements in erectile function [IIEF-5, median (IQR)?=?13.0 (7.0–18.0) versus 6.0 (5.0–6.75); p?p?Conclusion: PA in association with phosphodiesterase V inhibitors could compensate the effects of hypogonadism on erectile function and facilitate the clinical response to these drugs even in the absence of adequate serum concentrations of total testosterone.     

Incorporation of Migrant Students Returning From the United States to High Schools in Mexico

The purpose of this research was to identify the difficulties faced by the Mexican migrant students when incorporated into the Mexican education system after having studied in the United States of America. Thirty migrant middle school students, two principals, two social workers and one teacher participated in the study. The study (conducted in two phases) collected information regarding: school admission, adjustment to the school organization, adaptation to learning situations and the perception of school belonging. The main problems found during the admission and enrolment procedures in Mexican schools are: language use, diagnostic assessment, didactic processes that take place in the classroom, complementary support activities, grade repetition, very little family involvement and the separation of the students from their migrant parents.     

The Argentine welfare state: enduring and resisting change

Isuani EA. The Argentine welfare state: enduring and resisting change
Int J Soc Welfare 2010: 19: 104–114 © 2009 The Author(s), Journal compilation © 2009 Blackwell Publishing Ltd and the International Journal of Social Welfare. It is widely accepted that during the 1990s, the Argentine state experienced a general retrenchment. This article shows that, though this may have been true in the economic realm, this retrenchment did not take place in the diverse arenas of social policy. While privatisations and labour market flexibility dismantled the foundations of Keynesianism, the components of the welfare state experienced substantial growth. At the same time, the changes experienced by the welfare state in the past quarter century have not included a transformation of its basic principles, despite the profound changes experienced by Argentine society during this period.     

A cramer - von mises type goodness of fit test with asymmetric weight function

A goodness of fit test of the Cramer - von Mises type, which gives more weight to the upper (or to the lower) tail of the distribution, is proposed and studied. It is found the orthogonal representation of the test for the case of a simple null hypothesis. The characteristic function of the asymptotic null distribution is found and inverted to get percentage points. The asymptotic power of the test is obtained for the normal null hypothesis, against mean and variance shifts and more asymmetric alternatives.

Also the case of the exponential null hypothesis is studied. It is found that the test, which emphasizes the upper tail, has more power than those of Anderson - Darling and Cramer - von Mises, against alternatives which differ from the null hypothesis mainly in the upper tail, and less power when the main difference is in the lower tail of the distribution.     

罗马银行法探析——兼论商法起源问题

现在人们普遍认为商法产生于中世纪商人法,罗马法中无商法.该观点源自对商法范畴在历史语境下具体分析的阙如,其论据主要为罗马法律词汇中没有表示商法部门及区别于一般私法制度的概念和术语.通过分析原始文献可以发现这些论据是不成立的.裁判官为了因应罗马国家的扩张,在告示和相关司法活动中创造出一系列专门规制此等特殊法律关系的规范,昭示了实质意义上的商法的诞生,银行法为其重要组成部分.银行业活动在公元前4世纪便已在罗马出现,在商业化时代获得重大发展.为规范这些具有特殊性的活动,罗马法学在司法管辖、组织机构、账簿出示、抵销等具体制度中回应了实践的要求.在从商业化时代向优士丁尼时期的转变过程中,银行业经历了衰落与复兴,并在相关法律规范中映射了这一过程.     

Lower urinary tract symptoms/benign prostatic hyperplasia and erectile dysfunction: from physiology to clinical aspects

Abstract

Erectile dysfunction, prostatic hyperplasia and lower urinary tract symptoms hare important pathogenetic links. Endothelial dysfunction and hormonal alterations represent the main aspects. The present article examines the anatomical, physiological, and pathophysiological characteristics of this association, finalizing the text to an interpretation of the clinical management of these patients based on these functional considerations.     

Treatment of lower urinary tract symptoms/benign prostatic hyperplasia and erectile dysfunction

Abstract

This article summarizes years of challenging research on erectile dysfunction (ED), a condition that has an important social and cultural relevance. Preclinical and clinical research progress has led to new therapeutic approaches to ED in patients with different comorbidities and particularly in those with low urinary tract symptoms (LUTS)/benign prostatic hyperplasia (BPH). These goals were possible only by combined work of specialists and researchers of different and intertwined medical disciplines. Currently, tadalafil (5?mg/d) is the best choice; other phosphodiesterase-5 inhibitors (PDE5i) are not included among options, despite the growing evidence of therapeutic effects. Different regimens of tadalafil may be prescribed based on patient needs, severity of LUTS/BPH – ED profile, and clinical experience. An integrated approach is necessary to choose for a combined therapy with PDE5i and α-blockers following urological and cardiac counseling in terms of outcomes and adverse effects.     

Social loss with respect to the core of an economy

The dual notion of Pareto-efficiency (i.e., individual utilities cannot be reached with fewer resources than those of the allocation under consideration) is used in order to define the resources-core. A measure of social loss with respect to the core is then introduced, more or less as already done with respect to the locus of efficient allocations. Received: 4 December 2000/Accepted: 14 June 2001