Mediator role of intergroup anxiety in relationship between the social contact,intercultural sensitivity and attitudes towards Syrians among Turkish local society

Turkey is the country with the highest Syrian refugee population hosted in the world. Social acceptance of immigrants by the local community is as important as the social cohesion of immigrants regarding the social integration process. The aim of the current study was to examine the role of social contact, intercultural sensitivity, intergroup anxiety, gender, age, education, abroad experience and city on attitudes of Turkish local society towards Syrians. In this regard, data were collected from 207 local community members living in Ankara and Adana provinces of Turkey. According to the analysis, qualitative social contact, intercultural sensitivity and intergroup anxiety predicted the attitudes of the local community towards Syrians. In addition, intergroup anxiety had a mediating role between qualitative social contact, intercultural sensitivity and attitudes towards Syrians. When close social contact and intercultural sensitivity of Turkish local society increase, intergroup anxiety decreases and it increases positive attitudes towards Syrians. Lastly, while there was no gender difference in attitude towards Syrians, females were higher in intercultural sensitivity than males.     

Defining estimands for efficacy assessment in single arm phase 1b or phase 2 clinical trials in oncology early development

The addendum of the ICH E9 guideline on the statistical principles for clinical trials introduced the estimand framework. The framework is designed to strengthen the dialog between different stakeholders, to introduce greater clarity in the clinical trial objectives and to provide alignment between the estimand and statistical analysis. Estimand framework related publications thus far have mainly focused on randomized clinical trials. The intention of the Early Development Estimand Nexus (EDEN), a task force of the cross-industry Oncology Estimand Working Group ( www.oncoestimand.org ), is to apply it to single arms Phase 1b or Phase 2 trials designed to detect a treatment-related efficacy signal, typically measured by objective response rate. Key recommendations regarding the estimand attributes include that in a single arm early clinical trial, the treatment attribute should start when the first dose is received by the participant. Focusing on the estimation of an absolute effect, the population-level summary measure should reflect only the property used for the estimation. Another major component introduced in the ICH E9 addendum is the definition of intercurrent events and the associated possible ways to handle them. Different strategies reflect different clinical questions of interest that can be answered based on the journeys an individual subject can take during a trial. We provide detailed strategy recommendations for intercurrent events typically seen in early-stage oncology. We highlight where implicit assumptions should be made transparent as whenever follow-up is suspended, a while-on-treatment strategy is implied.     

Disorganized attachment,mentalization and dissociation in context of childhood trauma: Implications for depressive symptoms

Extensive evidence indicates that adults with experience of childhood trauma and disorganised attachment are at a higher risk of suffering from depressive symptoms, while at the same time dissociation and mentalisation are very important risk and protective factors in this relation. Although mentalisation and dissociation are mentioned as potential mediators of this relationship, very few studies have analysed the mutual relations between these variables. Bearing in mind the importance of creating more specific and effective ways for dealing with depression, especially within vulnerable groups such as the traumatised, the aim of this research is to examine a serial mediation model in which disorganisation is modelled as effecting a decrease in mentalisation, in turn lead to dissociation, thereby resulting in depressive symptoms. Adult respondents (N = 153) with a history of interpersonal childhood trauma were selected from a larger geographical cluster sample from the general population of Serbia. The respondents filled in a battery of instruments, including The Childhood Traumatic Events Scale, Relationship Questionnaire – CV, Patient Health Questionnaire, Short Scale for the Assessment of Stress-Related Dissociation Symptomatology and the Mentalisation Scale. Our findings suggest that disorganisation has an effect on depression by leading to a decrease in the ability to mentalise, which further triggers dissociation, resulting in depressive symptoms as a final consequence (estimated indirect effect = 0.014, 95 percent CI = 0.005 to 0.026). Additionally, the specific indirect effect involving dissociation as the sole mediator was also significant (estimated indirect effect = 0.058, 95 percent CI = 0.030 to 0.091). Targeting dissociative symptoms in the treatment in patients struggling with depression aftermath of traumatic experience could gain a great benefit for recognition and selection of more adequate treatment strategies.     

Within- and between-person associations among internalizing and externalizing problems during middle childhood

Internalizing and externalizing problems are likely to co-occur in childhood and are related to concurrent and prospective mental health outcomes. We examined the longitudinal relations among internalizing and externalizing problems during middle childhood utilizing the Random Intercept – Cross Lagged Panel Model. We investigated three research questions: (1) how overall levels of internalizing and externalizing problems are related, (2) whether internalizing and externalizing problems predict each other longitudinally, and (3) whether girls and boys show different longitudinal associations among internalizing and externalizing problems. Mother-reported internalizing and externalizing problems were used through first to sixth grade (N = 1364). Results showed positive random intercepts and positive within-time correlations of internalizing and externalizing problems. Further, internalizing problems predicted externalizing problems at the within-person level. Although previous research mostly has shown a significant effect from externalizing problems to internalizing problems, the current study shows that when within- and between-person variance are disentangled, internalizing problems also may predict externalizing problems.