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381.
A wide variety of prevention approaches that reduce substance use and associated problems have been developed and tested. But successes have been limited in promoting the use of these scientific advances by the policy makers, practitioners, and concerned citizens. The Center for Substance Abuse Prevention's six regional Centers for the Application of Prevention Technologies (CSAP's CAPTs) are a major mechanism by which CSAP brings research to practice. This article synthesizes the issues that the CAPTs have faced, the solutions they have developed, and conclusions concerning the work that still needs to be done to increase the application of science-based approaches to prevention. These discussions highlight the particular importance of addressing issues related to the larger systems in which prevention programs and strategies operate.  相似文献   
382.
Having been offered — and prepared to accept — a “centre-stage”role in the operation of the criminal justice system as recently as 1991, the Probation Service in England and Wales seems increasingly to be marginalized by politicians who, in a more punitive climate, have changed their minds about what is expected of it. As a probation spokesperson has recently said: “the big vision has gone”. One strand of policy which the Probation Service was expected to develop in 1991 was increased partnership with voluntary organizations, but, although progress has been made, it is a policy about which the Service has been very ambivalent, fearing that it may lead in the longer term to privatization of their work. This paper will outline the origins and implications of the policy, note how some local Services have so far responded to it, and suggest that, if pursued in certain fields of activity, partnership could contain an alternative vision to the one that has been lost.  相似文献   
383.
The authors' object is to provide a practical technique to help senior management put long range plans into operation. A model framework is used to identify the objective requirements and principal elements of control within the firm. A procedure is then outlined to identify the weaknesses which may erode the effectiveness of the system, thus providing the basis for system design and adaptation. The use of the method is illustrated in four case studies from actual companies.  相似文献   
384.
In this paper, we derive the probabilities that four chosen sampling schemes will detect a circular patch of organisms whose location is at some random location in the study area. We also describe simulations which indicate the variation of patch detection probabilities for different realizations of the sampling design. We comment briefly on how probabilities would be affected by multiple and different shaped patches. Our results are a useful guide for practitioners when choosing a design and an appropriate sampling intensity.  相似文献   
385.
Population Research and Policy Review - As states liberalize their cannabis laws, cannabis use has become more widespread among adults across the United States, including pregnant women. As a...  相似文献   
386.
387.
In recent years, the notion of business models has gained momentum in management research. Scholars have discussed several barriers to changing business models in established firms. However, the national institutions of market economies have not yet been discussed as barriers, even though they can constrain the latitude of action of a firm's management. Based on interviews and a longitudinal content analysis, we analyse the extent to which full service carriers in two countries (British Airways in the UK and Deutsche Lufthansa in Germany) have adopted elements of a low cost model over time. Furthermore, we investigate how this process has been influenced by the differences in each national institutional context. We particularly focus on the role of the rights of employee representatives in changes in business models. Our results show that British Airways has moved its business model more in the direction of low cost carriers than Deutsche Lufthansa, although the business model of the former airline still differs significantly from that of a typical low cost carrier. We identify national institutions that potentially strengthen the position of employee representatives as a factor that can influence, and also act as a barrier to, business model change.  相似文献   
388.
In 2010, the Statisticians in the Pharmaceutical Industry (PSI) Toxicology Special Interest Group met to discuss the design and analysis of the Comet assay. The Comet assay is one potential component of the package of safety studies required by regulatory bodies. As these studies usually involve a three-way nested experimental design and as the distribution of the measured response is usually either lognormal or lognormal plus a point mass at zero, the analysis is not straightforward. This has led to many different types of analysis being proposed in the literature, with several different methods applied within the pharmaceutical industry itself. This article summarises the PSI Toxicology Group's discussions and recommendations around these issues.  相似文献   
389.
In Ontario, Canada, the regulator approves identical looking slot machine games with different payback percentages. We gained access to the design documents (called PAR Sheets) used to program these different versions of the same slots game and ran Gambler’s Ruin simulations of 2,000 first-time players who each arrived with a $100 bankroll and played either the 85 or 98% version of the same game until broke. Simulations revealed that the typical (median) player’s experience did not differ significantly between versions. However the payback percentage affected the experience of players in the upper tails of the distributions with those in the 98% version having dramatically more total spins, winning spins, entries into the “bonus mode”, and “hand pays” (a win of $100 bankroll and played either the 85 or 98% version of the same game until broke. Simulations revealed that the typical (median) player’s experience did not differ significantly between versions. However the payback percentage affected the experience of players in the upper tails of the distributions with those in the 98% version having dramatically more total spins, winning spins, entries into the “bonus mode”, and “hand pays” (a win of 125 or more on a given spin). Most importantly, the number of simulated players who had a maximum peak balance in excess of $1,000 rose tenfold—from 5 in the 85% version to 54 in the 98% version. The results are discussed in terms of the Pathways Model of Problem and Pathological Gambling especially in terms of behavioural conditioning, cognitive beliefs, and early big wins. It may well be that those machines that are on the surface the “fairest” to the gambler, actually pose the most risk for ensuing gambling problems.  相似文献   
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