Improving Weight of Evidence Approaches to Chemical Evaluations

Federal and other regulatory agencies often use or claim to use a weight of evidence (WoE) approach in chemical evaluation. Their approaches to the use of WoE, however, differ significantly, rely heavily on subjective professional judgment, and merit improvement. We review uses of WoE approaches in key articles in the peer‐reviewed scientific literature, and find significant variations. We find that a hypothesis‐based WoE approach, developed by Lorenz Rhomberg et al., can provide a stronger scientific basis for chemical assessment while improving transparency and preserving the appropriate scope of professional judgment. Their approach, while still evolving, relies on the explicit specification of the hypothesized basis for using the information at hand to infer the ability of an agent to cause human health impacts or, more broadly, affect other endpoints of concern. We describe and endorse such a hypothesis‐based WoE approach to chemical evaluation.     

Assistive technology for disabled visual artists: exploring the impact of digital technologies on artistic practice

Abstract

Disabled artists with physical impairments can experience significant barriers in producing creative work. Digital technologies offer alternative opportunities to support artistic practice, but there has been a lack of research investigating the impact of assistive digital tools in this context. This article explores the current practice of physically impaired visual artists and their experiences around the use of digital technologies. An online survey was conducted with professional disabled artists and followed up by face-to-face interviews with 10 invited artists. The findings illustrate the issues disabled artists experience in their practice and highlight how they are commonly using mainstream digital technologies as part of their practice. However, there is little awareness around novel forms of technology (e.g. eye gaze tracking) that present new creative opportunities. The importance of digital tools for supporting wider practice (i.e. administrative and business tasks) was also highlighted as a key area where further work is required.     

Piloting different approaches to personalised offender management in the English criminal justice system

Various approaches to personalisation are well-established in the UK social care sector and are now starting to ‘travel’ to other sectors. In this paper we report findings from an evaluation of a pilot to test elements of personalisation in the management of offenders in probation services within the English criminal justice system. Following a review of evidence from social care, three different approaches to personalised-practice were developed and tested on a small-scale in three separate sites. The evaluation finds that all three approaches were implemented reasonably successfully, but challenges were identified including that personalised approaches are more time-consuming, that staff need support to exercise professional discretion and that balancing greater choice with managing criminogenic risk requires new ways of conceptualising the relationship between case manager and service user. Overall, ‘deeper’ approaches to personalisation, such as co-production, will take time to emerge. This paper makes two important contributions to the debate on personalisation in public services. First, it addresses the question of how transferable the concept of personalisation is from the social care sector to other sectors in the UK, in this case the criminal justice system. Secondly, it outlines a methodology for developing and evaluating personalisation pilots, prior to a wider roll-out.     

Public relations and artificial intelligence: It’s not (just) about robots

Organizations of all kinds, as well as their in-house or agency public relations teams, increasingly co-opt Artificial Intelligence (AI) to enhance their capabilities. This paper examines a relatively new topic that has received little scholarly attention: the growing relationship between AI and public relations. It outlines several key roles that AI may play in future, based on trends in other industries, and considers the implications for public relations practitioners, their clients and employers. It therefore launches a dialogue about the diversity and extent of AI’s uses in public relations practice. The paper argues that, to date, commentators have placed too much emphasis on AI’s potential for task automation; AI’s broader technological, economic and societal implications for public relations warrant greater critical attention. This does not imply that practitioners need become expert technologists; rather, they should develop a sufficient understanding of AI’s present and potential uses to be able to offer informed counsel.     

Toddlers Involve Their Caregiver to Help Another Person in Need

Three experiments with 18‐ to 35‐month‐old children (n = 169) studied toddler–caregiver interactions when being confronted with another person in need. In particular, we explored whether toddlers would request their caregiver to help a needy other when they are not able to help themselves. Children observed another person who needed help to accomplish a task, but were either not able to provide help as the object was out of reach (Experiment 1) or because an obstacle prevented children from interacting with the other person (Experiments 2, 2b). The experiments revealed the same developmental trend with 2.5‐year‐olds selectively involving their caregiver to help the needy other. The results are interpreted in terms of toddlers’ motivation to see others helped and with respect to their developing ability to actively involve others to regulate their emotions.     

Using Bayesian graphical models to model biases in observational studies and to combine multiple sources of data: application to low birth weight and water disinfection by-products

Summary.  Data in the social, behavioural and health sciences frequently come from observational studies instead of controlled experiments. In addition to random errors, observational data typically contain additional sources of uncertainty such as missing values, unmeasured confounders and selection biases. Also, the research question is often different from that which a particular source of data was designed to answer, and so not all relevant variables are measured. As a result, multiple sources of data are often necessary to identify the biases and to inform about different aspects of the research question. Bayesian graphical models provide a coherent way to connect a series of local submodels, based on different data sets, into a global unified analysis. We present a unified modelling framework that will account for multiple biases simultaneously and give more accurate parameter estimates than standard approaches. We illustrate our approach by analysing data from a study of water disinfection by-products and adverse birth outcomes in the UK.     

Does Fatherhood Matter for Men?

Ignored in the flurry of new research on fathers is that fatherhood may have consequences for men. This article explores possible effects on the lives and well‐being of men for a range of fatherhood experiences. Data are drawn from the National Survey of Families and Households. The first part of this article examines whether men's varied associations with children (no children, coresident, non‐coresident, and stepfatherhood) are associated with men's psychological health and behavior, social connections, intergenerational family relations, and work behavior. We found strong evidence that fathers differ from nonfathers in their social connections, family relationships, and work behavior. There is significant variation in effects among the father types as well. The second section of this article focuses attention only on men who are fathers and examines whether fathering behavior (e.g., the amount of time and nature of the activities that fathers are reported to be spending with their children) is associated with men's well‐being. The effects of father involvement on men was found to be most significant for those who were living with their own children.     

Business patterns within telecommunications

The global telecommunications changed from a number of co-operating national monopolies offering a restricted range of services to a competitive, growing market with players of many types and sizes, offering a large range of services. How can vertically integrated incumbents align themselves and their systems to best compete in this environment? Business patterns and enterprise modelling offer a tool to model a large organization as a number of smaller enterprises that can compete with and co-operate with smaller specialist players in the market. In order to identify enterprises, this paper proposes that there are only a limited number of types of enterprise (manufacturer, service supplier, reseller, that these enterprise types can only interact in a limited number of ways (component supply, aggregation supply, resell supply, trading, end-supply and commission). With the use of examples, this paper illustrates these types of enterprise and enterprise relationships, and how they can be combined to build both internal and external supply chains, and discusses some of the conclusions that can be drawn from this analysis.     

Internationalization and Performance of Firms in China: Moderating Effects of Governance Structure and the Degree of Centralized Control

This study proposes necessary modifications to the existing internationalization–performance relationship to meet the idiosyncrasies of China-specific contexts. We first hypothesize an S-shaped internationalization–performance relationship as the baseline and then investigate the moderating effects of a firm's governance structure and the degree of centralized government control on the relationship between its internationalization and performance. The results, based on a longitudinal sample of manufacturing firms in China for the 2001–2007 period, indicate that (1) the S-shaped internationalization–performance relationship holds for firms in China; (2) the governance structure moderates the internationalization–performance relationship such that increased profitability through internationalization is more likely for modernized firms than for their conventional local counterparts; and (3) the degree of centralized control moderates the internationalization–performance relationship such that increased profitability through internationalization is more likely for firms affiliated with higher level governments than for those affiliated with lower-level governments.     

Continuity and change in work-life balance choices

This paper explores the ways in which the work-life balance choices made by heterosexual couples differ in different generations, how such choices are gendered, and the extent to which 'individualization' provides an adequate conceptualization of the effects of social change on heterosexual couples. It argues that processes of individualization need to be seen in the context of changing social institutions, and that it is the de-institutionalization of 'the family' and the life course that is leading to a de-gendering of work-life balance choices. The paper draws on findings from a restudy of the family and social change and a study of the gender dimensions of job insecurity both of which were carried out in the same geographical location. The studies provide evidence of generational change in work-life balance choices and increasing occupational differentiation between heterosexual partners. This leads to a situation where increasingly choices are made which blur gendered boundaries and which has been made possible by a process of de-institutionalization of the male breadwinner family. Our findings support the contention that processes of individualization are more apparent amongst younger than older generations and that, because of changes external to the family, there is more negotiation and pragmatism amongst younger generations about work-life choices.