Could Removing Arsenic from Tobacco Smoke Significantly Reduce Smoker Risks of Lung Cancer?

If a specific biological mechanism could be determined by which a carcinogen increases lung cancer risk, how might this knowledge be used to improve risk assessment? To explore this issue, we assume (perhaps incorrectly) that arsenic in cigarette smoke increases lung cancer risk by hypermethylating the promoter region of gene p16INK4a, leading to a more rapid entry of altered (initiated) cells into a clonal expansion phase. The potential impact on lung cancer of removing arsenic is then quantified using a three‐stage version of a multistage clonal expansion (MSCE) model. This refines the usual two‐stage clonal expansion (TSCE) model of carcinogenesis by resolving its intermediate or “initiated” cell compartment into two subcompartments, representing experimentally observed “patch” and “field” cells. This refinement allows p16 methylation effects to be represented as speeding transitions of cells from the patch state to the clonally expanding field state. Given these assumptions, removing arsenic might greatly reduce the number of nonsmall cell lung cancer cells (NSCLCs) produced in smokers, by up to two‐thirds, depending on the fraction (between 0 and 1) of the smoking‐induced increase in the patch‐to‐field transition rate prevented if arsenic were removed. At present, this fraction is unknown (and could be as low as zero), but the possibility that it could be high (close to 1) cannot be ruled out without further data.     

Books received

A Wider Perspective Needed Avraham Greenbaum (ed.), Minority Problems in Eastern Europe Between the World Wars, with Emphasis on the Jewish Minority, introduced by Edward Allworth, Hebrew University of Jerusalem, Institute of Advanced Studies. Jerusalem, 1988. pp.viii, 163.

The Jokes of Oppression David A. Harris and Izrail Rabinovich, The Jokes of Oppression: The Humour of Soviet Jews. Northvale, NJ and London: Jason Aronson, 1988. 275pp. $22.50.

A Pleasant Surprise Franti?ek Mi?eje, Revolu?nou Cestou. Spomienky na roky 1938–1948 (On the Path of Revolution: Reminiscences of the Years 1938–1948.) Bratislava: Pravda publishers on behalf of the Institute of Marxism‐Leninism of the Central Committee of the Communist Party of Slovakia, 1988. 232 pp. Illus. Bibl. Index. Kcs 19.00.     

Social Development in Hong Kong: Development Issues Identified by Social Development Index (SDI)

Surviving the aftermaths of the Asian Financial Crisis and SARS in 2003, Hong Kong’s economy has re-gained its momentum and its economic growth has been quite remarkable too in recent few years. Nevertheless, as reflected by the Social Development Index (SDI), economic growth in Hong Kong does not seem to have benefited the people of the city at large as we see social qualities such as cohesion, security, equity, and empowerment are gradually eroded. This paper aims to summarize the current state of social development in Hong Kong based on the SDI-2008 and identify the major social, political and economic challenges that are confronted by Hong Kong. Based on the findings, a range of policy options proposed for promoting a more balanced approach to social and economic development are discussed. The article illustrates the utility of social indicators research such as the SDI in assessing quality of life and assisting related social planning initiatives in Asian communities such as Hong Kong.     

Preschoolers' Bistrategic Resource Control,Reconciliation, and Peer Regard

Bistrategic resource control entails using both coercive and prosocial strategies in competition for resources. The present study sought to clarify whether bistrategic involves more than simply using both strategies some of the time. Examining 88 preschoolers' coercion and prosociality over an entire school year, results showed that coercive resource control was used most frequently at the start of the school year, presumably to access resources and establish social dominance. Rates of prosocial resource control increased over the school year, and socially dominant preschoolers showed higher rates compared with peers, presumably to maintain resource control while keeping peers as allies. Socially dominant preschoolers also used reconciliation more often than peers, resulting in higher rates of affiliation between former competitors and more positive peer regard from fall to spring. Findings are discussed in terms of resource control theory and the importance of situating social behaviors within the behavioral and relationship context in which they are embedded.     

An examination of sexual strategies used by urban southern and rural Midwestern university women

The purposes of this study were (a) to determine whether women's use of persuasion, non‐physical coercion, and physical force strategies to obtain sex from a man varied between U.S. women from an urban Southern and rural Midwestern university and (b) to determine if sexual behavior history and early courtship behavior affected the use of these strategies (or not using any strategy). Women from the Midwest and the South did not differ in their use of sexual strategies. There were, however, other variables that accounted for differences in women's use of sexual strategies. Women who used persuasion strategies had fewer lifetime sexual partners than women who used any other strategy. Women who used physical force strategies reported a lower age at first intercourse and more early courtship behaviors than all others. Overall, the results indicated that sexual strategies are related to sexual behavior history and early courtship behaviors rather than cultural setting or demographics.     

Career Adaptability in Adults: A Construct Whose Time Has Come

This article describes Donald Super's construct of adaptability and reviews research on the construct. The review is followed by a discussion of related counseling research that uses the construct, and research in the area of organizational psychology that addresses the concept but does not use the term. The author summarizes other approaches to the need for adaptability in adult career development, and finally, presents suggestions for practitioners.     

INTERVENTION STRATEGIES: PREDICTING FAMILY THERAPY OUTCOME*

A pre-defined list of family therapy intervention strategies was used to predict post-therapy perceived life happiness and marital happiness among husbands and wives. Clients presented with both child and marriage-focused problems. The data were analyzed separately for husbands and wives. In general, favorable outcome for husbands was associated with active restructuring operations on the part of the therapist. Prediction of outcome for wives was less clear. However, wives did appear to respond favorably to less active interventions such as actualizing transactional patterns and reframing.     

Planning for permanency planning in foster care

The perceived severity of the problem of “drift” in the foster care system has encouraged agencies nationwide to accept permanency planning, but perhaps with limited attention to the planning process. This article examines the phenomenon of permanency planning from a planning perspective by focusing on: (a) definition of the permanency planning problem, (b) understanding of issues relevant to permanency planning (caseworker, program and systemic), (c) appreciation of the operational context (political, economic and social factors), and (d) evaluation of available options and possible consequences in developing or improving a permanency planning program. Permanency planning is not a simple, ready-made program applicable to any situation; it involves coordinated efforts by workers, service systems, and society in general, and requires time, commitment and resources. Successful planning for permanency planning can permit more children to grow up in homes providing continuity and stability.