The Role of Proactive Coping Strategies,Time Perspective,Perceived Efficacy on Affect Regulation,Divergent Thinking and Family Communication in Promoting Social Well-Being in Emerging Adulthood

The study analyzed the influence of time perspective, proactive coping strategies, perceived self-efficacy in affect regulation, divergent thinking and perceived quality of family communication on social well-being in a sample of 232 emerging adults. Social well-being showed positive correlations with proactive coping strategies, future-oriented time perspective, expression of positive emotions and regulation of negative emotions, divergent thinking, open communication with parents. A problematic family communication and a present-oriented time perspective were negatively correlated with social well-being. A forward Ridge step-wise regression model was conducted, evidencing four significant positive predictors of social well-being: proactive coping, perceived efficacy in affect regulation and open communication with parents; on the contrary, present oriented time perspective contributes significantly but negatively to social well-being.     

Reassessing Benzene Cancer Risks Using Internal Doses

Human cancer risks from benzene exposure have previously been estimated by regulatory agencies based primarily on epidemiological data, with supporting evidence provided by animal bioassay data. This paper reexamines the animal-based risk assessments for benzene using physiologically-based pharmacokinetic (PBPK) models of benzene metabolism in animals and humans. It demonstrates that internal doses (interpreted as total benzene metabolites formed) from oral gavage experiments in mice are well predicted by a PBPK model developed by Travis et al. Both the data and the model outputs can also be accurately described by the simple nonlinear regression model total metabolites = 76.4x/(80.75 + x), where x = administered dose in mg/kg/day. Thus, PBPK modeling validates the use of such nonlinear regression models, previously used by Bailer and Hoel. An important finding is that refitting the linearized multistage (LMS) model family to internal doses and observed responses changes the maximum-likelihood estimate (MLE) dose-response curve for mice from linear-quadratic to cubic, leading to low-dose risk estimates smaller than in previous risk assessments. This is consistent with the conclusion for mice from the Bailer and Hoel analysis. An innovation in this paper is estimation of internal doses for humans based on a PBPK model (and the regression model approximating it) rather than on interspecies dose conversions. Estimates of human risks at low doses are reduced by the use of internal dose estimates when the estimates are obtained from a PBPK model, in contrast to Bailer and Hoel's findings based on interspecies dose conversion. Sensitivity analyses and comparisons with epidemiological data and risk models suggest that our finding of a nonlinear MLE dose-response curve at low doses is robust to changes in assumptions and more consistent with epidemiological data than earlier risk models.     

Social Presence, Embarrassment, and Nonverbal Behavior

Nonverbal behaviors in response to viewing slides depicting nude males, nude females, erotic couples and neutral pictures, either alone or in the presence of two unfamiliar individuals, were studied in 22 female and 16 male university students. Participants were unaware of being videorecorded. Results revealed discrepancies between self-reported embarrassment and nonverbal behaviors supposedly expressive of embarrassment. Although self-reported embarrassment was higher when certain types of slides were viewed in the presence of others than when they were viewed alone, we observed significantly fewer lip movements, gaze shifts, face touches, downward gazes, and downward head movements in the presence of unfamiliar individuals than in the alone condition. We also compared behaviors during slide exposure and during the inter-slide intervals. For 9 out of 11 coded behaviors, frequencies were significantly higher during inter-slide intervals than during slide presentation. We argue that this is probably due to the fact that visual attention to the slides inhibited nonverbal behaviors. The results cast doubt on the possibility of inferring the internal state of an emotion such as embarrassment by analyzing nonverbal behaviors without taking account of the social setting in which such observations are made.