Slope-rotatable designs with equal maximum directional variance for second order response surface models

The concept of sloperotaiability with equal maximum directional vari ance for second order response surface models is introduced as a new design property. This requires that the maximum variance of the estimated slope over all possible directions be only a function of p, which is the distance from the design originif is shown that a rotatable design satisfies this property Also, minimization of tiie maximum variance of the estimated slope over all possible directions is proposed as a new design optirnality criterion, and op¬timal designs are called slope-directional minirnax designs. For the class of cquiradial designs, the slope-directional minirnax designs are compared with D— optimal designs.     

Smoothing techniques via the bezier curve

Although the Bezier curve is very popular in the area of computational graphics it has rarely been used by statisticians. In this paper we develop methods and techniques for use of the Bezier curve in estimation of density and regression function. Also, asymptotic mean integrated square error for both estimators are derived. Comparisons with kernel estimator are conducted using simulation.     

The power series distribution wite unknown truncation parameter: Two sample problem

The uniformly most powerful unbiased tests are formulated for the two sample problem of the power series distribution with unknown truncation parameter.     

Point estimation after early stopping in a repeated measures trial

When the individual measurements are statistically independent, the maximum likelihood estimator calculated at the end of a sequential procedure overestimates the underlying effect. There are many clinical trials in which we are interested in comparing changes in responses between two treatment groups sequentially. Lee and DeMets (1991, JASA 86, 757–762) proposed a group sequential method for comparing rates of change when a response variable is measured for eaeh patient at successive follow-up visits. They assumed that the response follows the linear mixed effects model and derived the asymptotic joint distribution of the sequentially computed statistics. In this article, we consider the maximum likelihood estimator (MLE), the median unbiased estimator (MUE) and the midpoint of a 100(1-α)% confidence interval as point estimators for the rate of change in the linear mixed effects model, and investigate their properties by Monte Carlo simulation.     

Kullback–Leibler information of a censored variable and its applications

In this paper, we study the Kullback–Leibler (KL) information of a censored variable, which we will simply call it censored KL information. The censored KL information is shown to have the necessary monotonicity property in addition to inherent properties of nonnegativity and characterization. We also present a representation of the censored KL information in terms of the relative risk and study its relation with the Fisher information in censored data. Finally, we evaluate the estimated censored KL information as a goodness-of-fit test statistic.     

Mobile use,personal values,and connectedness with civic life

This study aims to examine whether and how mobile communication enables citizens to translate their value orientations into their connectedness to the civic life. Specifically, we probe the indirect process in which different types of personal values predict key dimensions of engagement with civic affairs through patterns of mobile phone use. We show that individualism is indirectly associated with engagement with civic affairs through informational mobile use, whereas the link between collectivism and community involvement is positively intervened by relational mobile use. Additionally, socio-tropic empathy yields indirect relationships with civic engagement through informational mobile use. Implications of these findings are discussed.     

A Simple Toxicokinetic Model Exhibiting Complex Dynamics and Nonlinear Exposure Response

Uncertainty in model predictions of exposure response at low exposures is a problem for risk assessment. A particular interest is the internal concentration of an agent in biological systems as a function of external exposure concentrations. Physiologically based pharmacokinetic (PBPK) models permit estimation of internal exposure concentrations in target tissues but most assume that model parameters are either fixed or instantaneously dose-dependent. Taking into account response times for biological regulatory mechanisms introduces new dynamic behaviors that have implications for low-dose exposure response in chronic exposure. A simple one-compartment simulation model is described in which internal concentrations summed over time exhibit significant nonlinearity and nonmonotonicity in relation to external concentrations due to delayed up- or downregulation of a metabolic pathway. These behaviors could be the mechanistic basis for homeostasis and for some apparent hormetic effects.