Phase II trial design with growth modulation index as the primary endpoint

Molecularly targeted, genomic‐driven, and immunotherapy‐based clinical trials continue to be advanced for the treatment of relapse or refractory cancer patients, where the growth modulation index (GMI) is often considered a primary endpoint of treatment efficacy. However, there little literature is available that considers the trial design with GMI as the primary endpoint. In this article, we derived a sample size formula for the score test under a log‐linear model of the GMI. Study designs using the derived sample size formula are illustrated under a bivariate exponential model, the Weibull frailty model, and the generalized treatment effect size. The proposed designs provide sound statistical methods for a single‐arm phase II trial with GMI as the primary endpoint.     

Increased visceral adiposity index associated with sexual dysfunction in men

Objective: Visceral adipose index (VAI) is a novel parameter for the evaluation of visceral obesity. As we know that obesity is a risk factor for erectile dysfunction (ED). So, in this study, we compared the VAI levels between the men with ED and without ED.

Materials and method: A total of 177 men were included in the study. Ninety-five men with ED and 82 men without ED (control). All men were evaluated for ED by Index of Erectile Function-5 items (IIEF-5). VAI levels were calculated using body mass index, high density lipoprotein and tryglyceride levels.

Results: Mean age was 53.5 (38–69) in men who have ED and 53.1 (34–69) in control. The men with ED had higher body mass index (BMI), triglyceride (TG) levels, higher waist circumference (WC) and lower high-density lipoprotein-cholesterol (HDL-C) levels. Mean VAI level was 5.18?±?2.50 in study group and 3.47?±?1.76 in control goup, respectively. VAI levels were statistically higher in men with ED (p?Discussion: The simplicity of WC and BMI measurement and TG and HDL assessment, make VAI an easily applicable index for the evaluation of visceral fat dysfunction. VAI can be useful index for the evaluation and calculation of erectile dysfunction risk.     

构建大学生就业竞争力评价指标体系

随着大学生就业呈现竞争化、多元化趋势，对高校就业情况的衡量标准也应由“就业率”评价向“就业竞争力”评价转变。大学生就业竞争力评价指标体系主要包括主观就业竞争力与客观就业竞争力。硬实力和软实力构成主观就业竞争力，其中软实力包括基本职业人格、学习创新能力、团队组织能力、职业知识结构四方面，客观就业竞争力包含就业机会、就业成本、就业效率和就业质量等方面。     

Data envelopment analysis 1978–2010: A citation-based literature survey

This study surveys the data envelopment analysis (DEA) literature by applying a citation-based approach. The main goals are to find a set of papers playing the central role in DEA development and to discover the latest active DEA subareas. A directional network is constructed based on citation relationships among academic papers. After assigning an importance index to each link in the citation network, main DEA development paths emerge. We examine various types of main paths, including local main path, global main path, and multiple main paths. The analysis result suggests, as expected, that Charnes et al. (1978) [Charnes A, Cooper WW, Rhodes E. Measuring the efficiency of decision making units. European Journal of Operational Research 1978; 2(6): 429–444] is the most influential DEA paper. The five most active DEA subareas in recent years are identified; among them the “two-stage contextual factor evaluation framework” is relatively more active. Aside from the main path analysis, we summarize basic statistics on DEA journals and researchers. A growth curve analysis hints that the DEA literature’s size will eventually grow to at least double the size of the existing literature.     

工业主导产业选择的综合评价指标体系的构建

本文以经济学主导产业的有关理论为指导，利用统计方法，初步构建主导产业选择的指标体系。在此基础上通过评价指标的可行性分析、冗余度分析和区分度分析，并研究评价指标的权重选择和无量纲化处理．提炼出了适合一个区域，甚至一个国家的工业主导产业选择的测度指标体系。     

3-Decade Trend in Human Development Index in India and Its Major States

Social Indicators Research -     

为什么上市公司的治理水平存在差异?

公司治理水平在一国不同的公司之间存在较大差异.以南开大学公司治理指数来度量公司治理水平,在设定假设的基础上,通过回归分析治理水平存在差异性的原因可以发现,公司治理水平的高低主要与其股权结构、绩效水平、成长性、风险状况以及规模因素有关,同时外部的经济发展状况、法律环境也会对治理水平的提高有显著的促进作用.以上结果具有较强的稳健性.     

罗伯托·布萨和世界最早用计算机辅助编辑的巨著《托马斯著作索引》

意大利学者罗伯托·布萨在世界上最早用计算机辅助编辑大型书籍--《托马斯著作索引》,有力地推动了西方电子学术编辑的发展.他是国际公认的把计算机技术应用于人文科学的先驱者和相关新学科的创始人.这部56卷本百科全书式著作印刷版和电子版在1940-2005年的编辑出版以及布萨终生献给电子学术编辑事业的精神,对学术界和编辑出版界产生了深远影响.     

关于幸福指数的几个问题

幸福指数是在现代化理论研究过程中提出来的新观点，是人们对生活状况的一种主观感受，是一种心理体验。幸福指数又衍生出许多著名的理论成果：幸福政治观、幸福经济学、科学发展观等等；幸福指数测量指标的研究可以更加全面的衡量社会发展进步的状况，可以促进社会更加全面协调的发展。