Enabling robust assessment of QTc prolongation in early phase clinical trials

Since the implementation of the International Conference on Harmonization (ICH) E14 guideline in 2005, regulators have required a “thorough QTc” (TQT) study for evaluating the effects of investigational drugs on delayed cardiac repolarization as manifested by a prolonged QTc interval. However, TQT studies have increasingly been viewed unfavorably because of their low cost effectiveness. Several researchers have noted that a robust drug concentration‐QTc (conc‐QTc) modeling assessment in early phase development should, in most cases, obviate the need for a subsequent TQT study. In December 2015, ICH released an “E14 Q&As (R3)” document supporting the use of conc‐QTc modeling for regulatory decisions. In this article, we propose a simple improvement of two popular conc‐QTc assessment methods for typical first‐in‐human crossover‐like single ascending dose clinical pharmacology trials. The improvement is achieved, in part, by leveraging routinely encountered (and expected) intrasubject correlation patterns encountered in such trials. A real example involving a single ascending dose and corresponding TQT trial, along with results from a simulation study, illustrate the strong performance of the proposed method. The improved conc‐QTc assessment will further enable highly reliable go/no‐go decisions in early phase clinical development and deliver results that support subsequent TQT study waivers by regulators.     

受众心理分析视角的网络谣言治理

网络受众是网络谣言传播的主体，其不同的心理状态推动了网络谣言的生成与传播。网络受众的心理状态主要表现为泄愤心理、从众心理、窥私心理、投射心理以及选择心理等多种复杂的心理状态。这些心理状态的成因在于社会主义民主法制不健全、政府公信力低以及受众理性精神不足。唯有通过加强民主法制建设，健全网络法治监管，建立信息发布机制，建立辟谣中介组织以及加强网络媒介素养教育等途径，才能培育成熟的网络受众心理，从而提升网络谣言治理的成效。     

What Anonymous can tell us about the relationship between virtual community structure and participatory form

As a decentralised virtual community, Anonymous has been characterised by its oppositional tendencies. Helped by a collective persona and horizontal management structure, Anonymous has facilitated a myriad of differentiated agenda. However, we can observe a distinct change in its participatory form over time. So, while Anonymous, more broadly, functions as a virtual community, its means of engagement has shifted from a social movement to a decentralised cell network. This article explores the relationship between these changes, and its evolution as a virtual community. Drawing upon Iriberri and Leroy’s [(2009 Iriberri, A., and G. Leroy. 2009. “A Life-Cycle Perspective on Online Community Success.” ACM Computing Surveys (CSUR) 41 (2): 1–29. doi: 10.1145/1459352.1459356[Crossref], [Web of Science ®] , [Google Scholar]) “A Life-Cycle Perspective on Online Community Success.” ACM Computing Surveys (CSUR) 41 (2): 1–29] life cycle framework, the article maps Anonymous’ development and identifies the structural changes that have led to this transformation in its modes of participation.     

P2P 网络借贷研究进展及中国问题研究展望

P2P ( 个人对个人) 网络借贷是指通过网络借贷平台，在全球范围内实现个人与个人或小微企业间的小额信用借贷交易． P2P 网络借贷作为全新的互联网金融服务受到商业界的高度关注，而且发展成为学术研究的国际前沿领域． 对 P2P 网络借贷相关研究文献进行了综述，具体从影响借贷交易的信息因素、羊群效应以及社交网络等 3 个方面分析了该领域研究的现状和发展脉络． 因为中国已超越美国成为全球最大的 P2P 网络借贷交易市场，所以结合中国的具体情境和问题，提出了未来研究工作的展望．     

大众消费文化背景下高雅音乐推广路径研究——以福建省为例

大众消费文化背景下，福建省高雅音乐推广存在消费意识比较薄弱、高雅音乐自身“高”“雅”、消费环境不够完善等问题，对此，可通过提高认知因素、丰富自身因素、优化环境因素三个途径改进，以期提高福建人民精神文化水平，推进福建省社会文明发展。     

罗默与马克思剥削理论的比较分析

罗默是分析马克思主义学派的主要代表人物。他一方面认为马克思的思想至今依然具有强大的生命力，另一方面又彻底否定马克思剥削理论建立的基石——劳动价值论，并提出一种基于非劳动价值论的剥削理论。通过分析罗默剥削理论和马克思剥削理论在剥削存在的判断依据、剥削的源泉和目的、研究方法科学合理性以及剩余价值特殊表现形式四个方面的异同，指出罗默剥削理论既没有认识到剥削的本质，也没有充足理由驳倒马克思的劳动价值论。     

社会主义生态文明建设的重要内容: 生态消费模式

当前，我国消费伴随着经济的快速发展日益被异化为“病态式消费”模式，这使得国民经济的协调发展遭到了严重破坏，甚至生态系统也面临着崩溃的危险。我国新富群体缺乏正确的消费观念，加上西方消费主义影响，引发了诸多的社会问题。实践证明，只有树立正确的消费观念、克制消费欲望、调整消费行为，才能建立生态消费模式，才能符合社会主义生态文明的要求，实现人与自然的协调发展。     

Peer and Friend Influences on Children's Eating

Peers and friends are perceived as important role models for the formation of children's attitudes and behaviours. A wealth of research has aimed to establish the contribution of peers and friends to children's developing eating behaviours, and their attitudes towards eating. This review describes and evaluates such research. Experimental research examining peer modelling of food consumption and liking is reviewed, and several individual child factors that are suggested to make children more or less receptive to peer and friend influences are discussed. The influence of children's perceptions of their peers’ and friends’ eating behaviours upon their own eating practices is also explored. The benefits of future longitudinal research to improve understanding of peer and friend influences on children's eating are emphasized.     

城市文化软实力构建的“网都”范式

当前全球数字网络化的发展浪潮和历史背景下,"网都"型文化中心城市建设成为转变城市文化发展方式、提升城市文化软实力的新的战略路径和城市设计愿景。城市发展的"网都"形态具有多元文化范式,要根据不同城市的特点和文化基础,推进网络媒介城市(media city)、网络文化产业高地、网络文化名城、互联网总部基地、文化科技融合的创新引领中心、网络文化宜居之都、互联网枢纽城市等不同类型的"网都"建设。不同的网都范型(paradigm)关切到城市文化软实力的不同层面,存在着从硬文化实力向软文化实力的渐变和过渡谱系;既可以单独构建特色网络文化城市的核心性格与差异化竞争力,也可以综合构建城市文化软实力的体系化架构。     

文化产业化背景下电视剧《胡杨女人》的商品消费性特征解析

《胡杨女人》是文化产业化背景下生产的蒙古族题材电视剧。该剧得以在央视1套和8套连续4次反复播出,与其在创作方面的创新性探索不无关联,尤其突出表现为剧作的商品消费性特征明显,即注重讲故事、民俗文化参与叙事、自然景观的奇异化。该剧的成功为文化产业化时代蒙古族题材电视剧的创作提供了可供借鉴的范式。