Uncertainties in Pharmacokinetic Modeling for Perchloroethylene: II. Comparison of Model Predictions with Data for a Variety of Different Parameters

In this paper we compare expectations derived from 10 different human physiologically based pharmacokinetic models for perchloroethylene with data on absorption via inhalation, and concentrations in alveolar air and venous blood. Our most interesting finding is that essentially all of the models show a time pattern of departures of predictions of air and blood levels relative to experimental data that might be corrected by more sophisticated model structures incorporating either (a) heterogeneity of the fat compartment (with respect to either perfusion or partition coefficients or both) or (b) intertissue diffusion of perchloroethylene between the fat and muscle/VRG groups. Similar types of corrections have recently been proposed to reduce analogous anomalies in the fits of pharmacokinetic models to the data for several volatile anesthetics.^(17-20) A second finding is that models incorporating resting values for alveolar ventilation in the region of 5.4 L/min seemed to be most compatible with the most reliable set of perchloroethylene uptake data.     

Mlonte Carlo Techniques for Quantitative Uncertainty Analysis in Public Health Risk Assessments

Most public health risk assessments assume and combine a series of average, conservative, and worst-case values to derive a conservative point estimate of risk. This procedure has major limitations. This paper demonstrates a new methodology for extended uncertainty analyses in public health risk assessments using Monte Carlo techniques. The extended method begins as do some conventional methods--with the preparation of a spreadsheet to estimate exposure and risk. This method, however, continues by modeling key inputs as random variables described by probability density functions (PDFs). Overall, the technique provides a quantitative way to estimate the probability distributions for exposure and health risks within the validity of the model used. As an example, this paper presents a simplified case study for children playing in soils contaminated with benzene and benzo(a)pyrene (BaP).     

Machine learning for multi-criteria inventory classification applied to intermittent demand

Multi-criteria inventory classification groups inventory items into classes, each of which is managed by a specific re-order policy according to its priority. However, the tasks of inventory classification and control are not carried out jointly if the classification criteria and the classification approach are not robustly established from an inventory-cost perspective. Exhaustive simulations at the single item level of the inventory system would directly solve this issue by searching for the best re-order policy per item, thus achieving the subsequent optimal classification without resorting to any multi-criteria classification method. However, this would be very time-consuming in real settings, where a large number of items need to be managed simultaneously.

In this article, a reduction in simulation effort is achieved by extracting from the population of items a sample on which to perform an exhaustive search of best re-order policies per item; the lowest cost classification of in-sample items is, therefore, achieved. Then, in line with the increasing need for ICT tools in the production management of Industry 4.0 systems, supervised classifiers from the machine learning research field (i.e. support vector machines with a Gaussian kernel and deep neural networks) are trained on these in-sample items to learn to classify the out-of-sample items solely based on the values they show on the features (i.e. classification criteria). The inventory system adopted here is suitable for intermittent demands, but it may also suit non-intermittent demands, thus providing great flexibility. The experimental analysis of two large datasets showed an excellent accuracy, which suggests that machine learning classifiers could be implemented in advanced inventory classification systems.     

Mixed Levels of Uncertainty in Complex Policy Models

The characterization and treatment of uncertainty poses special challenges when modeling indeterminate or complex coupled systems such as those involved in the interactions between human activity, climate and the ecosystem. Uncertainty about model structure may become as, or more important than, uncertainty about parameter values. When uncertainty grows so large that prediction or optimization no longer makes sense, it may still be possible to use the model as a behavioral test bed to examine the relative robustness of alternative observational and behavioral strategies. When models must be run into portions of their phase space that are not well understood, different submodels may become unreliable at different rates. A common example involves running a time stepped model far into the future. Several strategies can be used to deal with such situations. The probability of model failure can be reported as a function of time. Possible alternative surprises can be assigned probabilities, modeled separately, and combined. Finally, through the use of subjective judgments, one may be able to combine, and over time shift between models, moving from more detailed to progressively simpler order-of-magnitude models, and perhaps ultimately, on to simple bounding analysis.     

具有不确定的时滞微分系统的稳定性

研究具有不确定的时滞微分大系统的鲁棒稳定性问题，利用李雅普诺夫函数和不等式分析方法，给出了不确定性时滞微分大系统在不依赖时滞的反馈分散控制下是稳定化的、渐近稳定化和指数稳定化的充分条件。     

Uncertainty and the Second Space: Modern Birth Timing and the Dilemma of Education

This paper focuses on the relationship between experiential and statistical uncertainties in the timing of births in Cameroon (Central Africa). Most theories of fertility level and change emphasize the emergence of parity-specific control, treating desired family size as both central, and stable across the life course. By contrast, this paper argues for a theory of reproduction that emphasizes process, social context, and contingency. The paper concentrates on the second birth interval, showing that it is longer and more variable among educated than among uneducated women. The paper argues that this difference is due to the specific forms of uncertainty associated with education in contemporary Cameroon.     

Modeling the demand reduction input-output (I-O) inoperability due to terrorism of interconnected infrastructures.

Interdependency analysis in the context of this article is a process of assessing and managing risks inherent in a system of interconnected entities (e.g., infrastructures or industry sectors). Invoking the principles of input-output (I-O) and decomposition analysis, the article offers a framework for describing how terrorism-induced perturbations can propagate due to interconnectedness. Data published by the Bureau of Economic Analysis Division of the U.S. Department of Commerce is utilized to present applications to serve as test beds for the proposed framework. Specifically, a case study estimating the economic impact of airline demand perturbations to national-level U.S. sectors is made possible using I-O matrices. A ranking of the affected sectors according to their vulnerability to perturbations originating from a primary sector (e.g., air transportation) can serve as important input to risk management. For example, limited resources can be prioritized for the "top-n" sectors that are perceived to suffer the greatest economic losses due to terrorism. In addition, regional decomposition via location quotients enables the analysis of local-level terrorism events. The Regional I-O Multiplier System II (RIMS II) Division of the U.S. Department of Commerce is the agency responsible for releasing the regional multipliers for various geographical resolutions (economic areas, states, and counties). A regional-level case study demonstrates a process of estimating the economic impact of transportation-related scenarios on industry sectors within Economic Area 010 (the New York metropolitan region and vicinities).     

浅谈书籍设计的人性化

“人性化设计”已成为 2 1世纪设计的主题。书籍设计作为视觉传达的重要门类也将遵循以人为本的理念。通过书籍封面、插图、版式、文字、材料等元素用设计语言概括书的本质 ,形象地反映书的知识要义和思想精髓 ,强调理性的秩序 ,准确传达知识和思想 ,使之理性的内涵和感性的外延相结合 ,成为读者获取知识、陶冶情操的桥梁     

Fusion of Intelligence Information: A Bayesian Approach

The attack that occurred on September 11, 2001 was, in the end, the result of a failure to detect and prevent the terrorist operations that hit the United States. The U.S. government thus faces at this time the daunting tasks of first, drastically increasing its ability to obtain and interpret different types of signals of impending terrorist attacks with sufficient lead time and accuracy, and second, improving its ability to react effectively. One of the main challenges is the fusion of information, from different sources (U.S. or foreign), and of different types (electronic signals, human intelligence. etc.). Fusion thus involves two very distinct and separate issues: communications, i.e., ensuring that the different U.S. and foreign intelligence agencies communicate all relevant and accurate information in a timely fashion and, perhaps more difficult, merging the content of signals, some "sharp" and some "fuzzy," some dependent and some independent into useful information. The focus of this article is on the latter issue, and on the use of the results. In this article, I present a classic probabilistic Bayesian model sometimes used in engineering risk analysis, which can be helpful in the fusion of information because it allows computation of the posterior probability of an event given its prior probability (before the signal is observed) and the quality of the signal characterized by the probabilities of false positive and false negative. Experience suggests that the nature of these errors has been sometimes misunderstood; therefore, I discuss the validity of several possible definitions.     

论文化产品与“政府文化需求”

文章试图用经济学原理,以"需求"为基本范畴,分析社会文化产品生产、流通、消费的基本规律,揭示文化产品的价值和使用价值相统一的商品属性.文中特别提出了文化产品"政府消费"的概念,意在解决"公益文化"的市场定位问题,并为转变文化行政部门职能、改革现有文化事业单位体制、创新政府文化投入的拨款方式提供一定的理论依据.