A case–control study relating railroad worker mortality to diesel exhaust exposure using a threshold regression model

A case–control study of lung cancer mortality in U.S. railroad workers in jobs with and without diesel exhaust exposure is reanalyzed using a new threshold regression methodology. The study included 1256 workers who died of lung cancer and 2385 controls who died primarily of circulatory system diseases. Diesel exhaust exposure was assessed using railroad job history from the US Railroad Retirement Board and an industrial hygiene survey. Smoking habits were available from next-of-kin and potential asbestos exposure was assessed by job history review. The new analysis reassesses lung cancer mortality and examines circulatory system disease mortality. Jobs with regular exposure to diesel exhaust had a survival pattern characterized by an initial delay in mortality, followed by a rapid deterioration of health prior to death. The pattern is seen in subjects dying of lung cancer, circulatory system diseases, and other causes. The unique pattern is illustrated using a new type of Kaplan–Meier survival plot in which the time scale represents a measure of disease progression rather than calendar time. The disease progression scale accounts for a healthy-worker effect when describing the effects of cumulative exposures on mortality.     

Nonparametric control charts based on runs and Wilcoxon-type rank-sum statistics

In this article, we introduce three new distribution-free Shewhart-type control charts that exploit run and Wilcoxon-type rank-sum statistics to detect possible shifts of a monitored process. Exact formulae for the alarm rate, the run length distribution, and the average run length (ARL) are all derived. A key advantage of these charts is that, due to their nonparametric nature, the false alarm rate (FAR) and in-control run length distribution is the same for all continuous process distributions. Tables are provided for the implementation of the charts for some typical FAR values. Furthermore, a numerical study carried out reveals that the new charts are quite flexible and efficient in detecting shifts to Lehmann-type out-of-control situations.     

Asymptotic distributions for the intervals estimators of the extremal index and the cluster-size probabilities

Under appropriate long range dependence conditions, the point process of exceedances of a stationary sequence weakly converges to a homogeneous compound Poisson point process. This limiting point process can be characterized by the extremal index and the cluster-size probabilities. In this paper we address the problem of estimating these quantities and we consider the intervals estimators introduced in Ferro and Segers [2003. Inference for clusters of extreme values. J. Roy. Statist. Soc. Ser. B 545–556] and in Ferro [2004. Statistical methods for clusters of extreme values. Ph.D. Thesis, Lancaster University]. We establish asymptotic weak convergence to Gaussian random variables and we give their asymptotic variance.     

Nonparametric estimation of the shape function in a Gamma process for degradation data

The author considers estimation under a Gamma process model for degradation data. The setting for degradation data is one in which n independent units, each with a Gamma process with a common shape function and scale parameter, are observed at several possibly different times. Covariates can be incorporated into the model by taking the scale parameter as a function of the covariates. The author proposes using the maximum pseudo‐likelihood method to estimate the unknown parameters. The method requires usage of the Pool Adjacent Violators Algorithm. Asymptotic properties, including consistency, convergence rate and asymptotic distribution, are established. Simulation studies are conducted to validate the method and its application is illustrated by using bridge beams data and carbon‐film resistors data. The Canadian Journal of Statistics 37: 102‐118; 2009 © 2009 Statistical Society of Canada     

企业组织创新与生产率关系的实证研究：以纺织业为例的讨论

本文结合国际创新实证研究新动态,在将创新定义扩展的基础上,以纺织业为例,分析组织创新对于企业生产率的影响。实证研究表明,在企业分规模、分经济类型和分地区的情况下,组织创新对于企业生产率的提高具有显著的影响,只是影响程度各有不同。因此,促进企业组织创新,拓展对创新观念的认识,从而提高企业生产率是应当考虑的企业增长路径之一。     

Nonparametric and semiparametric estimation of the three way receiver operating characteristic surface

In many situations the diagnostic decision is not limited to a binary choice. Binary statistical tools such as receiver operating characteristic (ROC) curve and area under the ROC curve (AUC) need to be expanded to address three-category classification problem. Previous authors have suggest various ways to model the extension of AUC but not the ROC surface. Only simple parametric approaches are proposed for modeling the ROC measure under the assumption that test results all follow normal distributions. We study the estimation methods of three-dimensional ROC surfaces with nonparametric and semiparametric estimators. Asymptotical results are provided as a basis for statistical inference. Simulation studies are performed to assess the validity of our proposed methods in finite samples. We consider an Alzheimer's disease example from a clinical study in the US as an illustration. The nonparametric and semiparametric modelling approaches for the three way ROC analysis can be readily generalized to diagnostic problems with more than three classes.     

Posterior Analysis for Normalized Random Measures with Independent Increments

Abstract.  One of the main research areas in Bayesian Nonparametrics is the proposal and study of priors which generalize the Dirichlet process. In this paper, we provide a comprehensive Bayesian non-parametric analysis of random probabilities which are obtained by normalizing random measures with independent increments (NRMI). Special cases of these priors have already shown to be useful for statistical applications such as mixture models and species sampling problems. However, in order to fully exploit these priors, the derivation of the posterior distribution of NRMIs is crucial: here we achieve this goal and, indeed, provide explicit and tractable expressions suitable for practical implementation. The posterior distribution of an NRMI turns out to be a mixture with respect to the distribution of a specific latent variable. The analysis is completed by the derivation of the corresponding predictive distributions and by a thorough investigation of the marginal structure. These results allow to derive a generalized Blackwell–MacQueen sampling scheme, which is then adapted to cover also mixture models driven by general NRMIs.     

Darling–Erdős limit results for change-point detection in panel data

We wish to test the null hypothesis if the means of N panels remain the same during the observation period of length T. A quasi-likelihood argument leads to self-normalized statistics whose limit distribution under the null hypothesis is double exponential. The main results are derived assuming that the each panel is based on independent observations and then extended to linear processes. The proofs are based on an approximation of the sum of squared CUSUM processes using the Skorokhod embedding scheme. A simulation study illustrates that our results can be used in case of small and moderate N and T. We apply our results to detect change in the “corruption index”.     

Model-based confidence bands for survival functions

This paper focuses on a novel method of developing one-sample confidence bands for survival functions from right censored data. The approach is model-based, relying on a parametric model for the conditional expectation of the censoring indicator given the observed minimum, and derives its strength from easy access to a good-fitting model among a plethora of choices available for binary response data. The substantive methodological contribution is in exploiting a semiparametric estimator of the survival function to produce improved simultaneous confidence bands. To obtain critical values for computing the confidence bands, a two-stage bootstrap approach that combines the classical bootstrap with the more recent model-based regeneration of censoring indicators is proposed and a justification of its asymptotic validity is also provided. Several different confidence bands are studied using the proposed approach. Numerical studies, including robustness of the proposed bands to misspecification, are carried out to check efficacy. The method is illustrated using two lung cancer data sets.     

Bayesian inference with misspecified models

This article reviews Bayesian inference from the perspective that the designated model is misspecified. This misspecification has implications in interpretation of objects, such as the prior distribution, which has been the cause of recent questioning of the appropriateness of Bayesian inference in this scenario. The main focus of this article is to establish the suitability of applying the Bayes update to a misspecified model, and relies on representation theorems for sequences of symmetric distributions; the identification of parameter values of interest; and the construction of sequences of distributions which act as the guesses as to where the next observation is coming from. A conclusion is that a clear identification of the fundamental starting point for the Bayesian is described.