Estimation of Metabolic Rate Constants in PBPK‐Models from Liver Slice Experiments: What Are the Experimental Needs?

A mechanistic model is presented describing the clearance of a compound in a precision-cut liver slice that is incubated in a culture medium. The problem of estimating metabolic rate constants in PBPK models from liver slice experiments is discussed using identifiability analysis. From the identifiability problem analysis, it appears that in addition to the clearance, the compound's free fraction in the slice and the diffusion rate of the exchange of the compound between culture medium and liver slice should be identified. In addition, knowledge of the culture medium volume, the slice volume, the compound's free fraction, and octanol-water-based partition between medium and slice is presupposed. The formal solution for identification is discussed from the perspective of experimental practice. A formally necessary condition for identification is the sampling of parent compound in liver slice or culture medium. However, due to experimental limitations and errors, sampling the parent compound in the slice together with additional sampling of metabolite pooled from the medium and the slice is required for identification in practice. Moreover, it appears that identification results are unreliable when the value of the intrinsic clearance exceeds the value of the diffusion coefficient, a condition to be verified a posteriori.     

定期租船合同下承运人识别问题研究

在海上货物运输中，以定期租船运输货物时，无论是船东，还是承租人都可能成为承运人。如何确定海上货物运输合同责任主体是海事审判实践中亟待解决的一个理论和实际问题。该文系统分析了定期租船合同下承运人识别问题产生的渊源、承运人识别的依据及其方法，在此基础上作者提出了解决定期租船合同下承运人识别问题的初步建议。     

带中西文量纲演算与转换的符号演算系统

本文介绍作者在自己研制的一个集成化支撑环境支持下，采用公理化方法所开发出的又一个应用系统。在这个系统中，除了可以把古今外多种单位制转换为SI制，可以作多种单位间的量纲转换外，还可以对带中西文量钠的广义表达式作符号演算和数值计算，这是目前其他中外系统暂时都无法实现的功能。这个系统已集成到《推理与计算混合软件包》中。     

一种基于Web的身份鉴别策略及其实现

介绍了Java服务端网页在IBM WebSphere平台上进行电子商务系统开发的相关原理和模型,提出了一种基于Web方式的用户身份鉴别策略,改进了以往在对用户身份鉴别时需要自己输入密码的方式。整个处理流程遵循J2EE规范,并贯穿了Web应用模式的三层体系结构,在存储过程中完成认证,这种方法对提高电子商务系统的安全性有一定的现实意义。     

The Boston Area Diary Study and the Moral Citizenship of Care

This paper describes the theoretical foundations, empirical findings, and practical and philosophical implications of the Boston Area Diary Study (BADS), a study of the caring behavior of 44 participants over one calendar year. In particular, the paper presents an identification theory of care and discusses how it shaped the conceptualization, collection, and analysis of the data in a year-long diary study of daily voluntary assistance. The findings from the BADS (1) theoretically confirm the identification theory of care; (2) methodologically capture how individuals perceive and carry out caring behavior as a unity; and (3rpar; empirically document the existence of a moral citizenship in America that is substantially more vigorous than is implied by the usual indicators of civic and political citizenship.     

转子动不平衡载荷的在线识别

本文提出用复模态影响系数来解决转了大衡的在线以别和诊断问题，讨论了影响系数矩阵的力学意义．试验中可不加试重求出影响系数，并编制了相应的计算程序．     

Nonresponse weighting adjustment using estimated response probability

To reduce nonresponse bias in sample surveys, a method of nonresponse weighting adjustment is often used which consists of multiplying the sampling weight of the respondent by the inverse of the estimated response probability. The authors examine the asymptotic properties of this estimator. They prove that it is generally more efficient than an estimator which uses the true response probability, provided that the parameters which govern this probability are estimated by maximum likelihood. The authors discuss variance estimation methods that account for the effect of using the estimated response probability; they compare their performances in a small simulation study. They also discuss extensions to the regression estimator.     

A strategy for third-party logistics systems: A case analysis using the blue ocean strategy

One of today's most frequently discussed topics in the business world is how to escape from the intense Red Ocean and how to create an uncontested Blue Ocean. However, because there are few practical guidelines available on this topic, we will introduce a case study of a third-party logistics (3PL) provider, CJ-Global Logistics Service (CJ-GLS), to show how it aspires to be a leader in the newly introduced 3PL industry in South Korea. CJ-GLS is a latecomer in the logistics industry, and its resources, such as the number of trucks and warehouses, are relatively small in comparison to those of established companies. But, it has achieved a distinct competitive advantage through innovative information technology (i.e., RFID—radio frequency identification), which has enabled it to create an uncontested market space, electronic logistics business. One remarkable fact about CJ-GLS is that its swift growth comes not from attracting competitors’ customers from the existing Red Ocean market but from creating a Blue Ocean market (3PL market), which previously existing incumbents ignored, and also from constructing a new business model founded on a RFID-based, ubiquitous-oriented 3PL system. Analyzed through a Four Actions Framework and characterized as Blue Ocean, this case study provides valuable information on how a company reinforces its competitive advantage from the Red Ocean while it transitions into a Blue Ocean by utilizing advanced information communication technologies.     

现代汉语语义系统刍议

语义单位、语义单位之间的结构关系、结构层次是现代汉语语言意义系统的三要素 ,不同性质的语义单位彼此之间复杂纠联 ,使构成语义系统的两子系统 (词汇意义、语法意义子系统 )、两次子系统 (词法意义、句法意义次子系统 )紧密地联结在—起 ,构成一个统一的内部饶有联系的结构整体     

分类定位 整合资源：我国事业单位改革的关键

目前我国的改革开放已到了攻坚阶段,事业单位改革作为对计划经济体制核心部分改造的一项重要工程,改革难度极大.本文针对我国事业单位目前存在的问题,提出分类定位、整合事业单位资源是我国事业单位改革的关键.