On the Effect of Probability Distributions of Input Variables in Public Health Risk Assessment

A central part of probabilistic public health risk assessment is the selection of probability distributions for the uncertain input variables. In this paper, we apply the first-order reliability method (FORM)^(1–3) as a probabilistic tool to assess the effect of probability distributions of the input random variables on the probability that risk exceeds a threshold level (termed the probability of failure) and on the relevant probabilistic sensitivities. The analysis was applied to a case study given by Thompson et al. ⁽⁴⁾ on cancer risk caused by the ingestion of benzene contaminated soil. Normal, lognormal, and uniform distributions were used in the analysis. The results show that the selection of a probability distribution function for the uncertain variables in this case study had a moderate impact on the probability that values would fall above a given threshold risk when the threshold risk is at the 50th percentile of the original distribution given by Thompson et al. ⁽⁴⁾ The impact was much greater when the threshold risk level was at the 95th percentile. The impact on uncertainty sensitivity, however, showed a reversed trend, where the impact was more appreciable for the 50th percentile of the original distribution of risk given by Thompson et al. ⁴ than for the 95th percentile. Nevertheless, the choice of distribution shape did not alter the order of probabilistic sensitivity of the basic uncertain variables.     

Perception of Ecological Risk to Water Environments

This paper examines lay and expert perceptions of the ecological risks associated with a range of human activities that could adversely affect water resource environments. It employs the psychometric paradigm pioneered in characterizing perceptions of human health risks, which involves surveys to obtain judgments from subjects about risk items in terms of several important characteristics of the risks. The paper builds on a previous study that introduced ecological risk perception. This second study employs a larger, more diverse sample, a more focused topic area, and comparisons between lay and expert judgments. The results confirm that a small set of underlying factors explain a great deal of variability in lay judgments about ecological risks. These have been termed Ecological Impact, Human Benefits, Controllability , and Knowledge. The results are useful in explaining subjects' judgments of the general riskiness of, and need for regulation of, various risk items. The results also indicate several differences and areas of agreement among the lay and expert samples that point to potential key issues in future ecological risk management efforts for water resources.     

ATSDR Science Panel on the Bioavailability of Mercury in Soils: Lessons Learned

On the basis of discussion and analysis during and following an ATSDR science panel on the bioavailability of mercury in soils, it is apparent that the default assumption of 100% relative bioavailability for mercury-contaminated soils is excessively conservative. However, current knowledge does not allow the development of default assumptions or guidelines for determining relative bioavailability of mercury in soils. Until such default assumptions or guidelines can be developed, site-specific assays of bioavailability, preferably using either animal bioassays or validated in vitro techniques, may provide the best approach for estimating soil-mercury bioavailability.     

Industry and the environment: a case study of cleaner technologies in selected European countries

The aim of this case study is to discuss the role of technology in addressing environmental problems. The paper tries to scratch beneath the surface of the increasingly frequent ‘quick-fix’ solutions to the present environmental problems, based on such beguiling catchwords as Cleaner Technologies, Best Available Technologies, and Best Available Technologies Not Exceeding Excessive Costs, etc., in an attempt to discover whether there is any substance in them, or whether they are just full of hot air. Recent data from case studies performed by the author in Germany and Finland as well as a postal questionnaire in Denmark are presented. The paper analyses and discusses the roles and responsibilities of designers, industrialists, and government policy-makers. It is argued that existing regulatory regimes, supranational industrial structures, and market mechanisms do not favour the development of cleaner technologies, nor do they promote a reduction in consumption patterns. Evidence from ongoing empirical research in Northwest Europe suggests that industry is far from developing and/or implementing cleaner technologies. The paper closes with a discussion of some of the policy implications involved and some examples of urgently needed further research.     

中国股票市场的信息反应曲线和股票价格波动的非对称性

股票价格波动对于市场信息的反应过程具有非对称性。通过利用多种非对称性GARCH 模型,描述和检验了沪市股票日收益率序列的条件波动性,并通过对股票市场信息影响曲线的分析,发现沪市股票价格波动中存在显著的非对称性反应。这说明股市波动对于不同的政策干预和信息冲击具有不同程度的反应,“利好消息”对股市的刺激作用仍然需要其他市场干预的配合才能发挥出来。     

论概率安全评价中的组织风险因素

核电站组织风险已经成为核电站安全运行重要的影响因素,在概率安全评价中考虑组织风险因素是核电安全研究的重要课题。文章在建立组织风险因素与PSA之间转换的概念框架的基础上,对组织风险因素进行分类。分类后的组织风险因素受人员行为形成因子的影响,其影响在人因可靠性分析中进行分析。计算和评估这些人员行为形成因子对于事故后操纵员的影响可以计算组织因素对核电站安全的影响。     

中国城镇化对服务业影响的区域差异——基于系统GMM模型的实证研究

目前中国服务业的发展离不开城镇化这一现实背景.文章选取2005-2015年省际面板数据,运用动态面板模型系统广义矩估计(SGMM)方法分别就城镇化对全国服务业发展的影响及其区域差异所做的实证研究结果表明:在全国层面上,城镇化水平对服务业发展有较显著的促进作用,但促进作用还比较小;在区域层面上,东部、中部、西部三大区域城镇化对服务业发展的影响也较小,且存在较明显的地区差异.基于研究结果,文章提出了从战略高度上重视加快新型城镇化进程以促进中国服务业更好发展,同时根据各区域的实际情况制定适宜的以城镇化促进服务业发展的政策措施等相关建议.     

Using Technology to Facilitate Collaboration in Community-Based Participatory Research (CBPR)

This study explores the use of Computer-Supported Collaborative Work (CSCW) technologies, by way of a computer-based system called iCohere. This system was used to facilitate collaboration conducting Community-Based Participatory Research (CBPR). Data was gathered from 13 members of a Community Collaborative Board (CCB). Analysis revealed that iCohere served the following functions: facilitating communication, providing a depository for information and resource sharing, and allowing for remote meeting attendance. Results indicated that while iCohere was useful in performing these functions, less expensive technologies had the potential to achieve similar goals if properly implemented. Implications for future research on CSCW systems and CBPR are discussed.     

Assessing Risk‐Based Upper Limits of Melamine Migration from Food Containers

Melamine contamination of food has become a major food safety issue because of incidents of infant disease caused by exposure to this chemical. This study was aimed at establishing a safety limit in Taiwan for the degree of melamine migration from food containers. Health risk assessment was performed for three exposure groups (preschool children, individuals who dine out, and elderly residents of nursing homes). Selected values of tolerable daily intake (TDI) for melamine were used to calculate the reference migration concentration limit (RMCL) or reference specific migration limit (RSML) for melamine food containers. The only existing values of these limits for international standards today are 1.2 mg/L (0.2 mg/dm²) in China and 30 mg/L (5 mg/dm²) in the European Union. The factors used in the calculations included the specific surface area of food containers, daily food consumption rate, body weight, TDI, and the percentile of the population protected at a given migration concentration limit (MCL). The results indicate that children are indeed at higher risk of melamine exposure at toxic levels than are other groups and that the 95th percentile of MCL (specific surface area = 5) for children aged 1–6 years should be the RMCL (0.07 mg/dm²) for protecting the sensitive and general population.     

Sensitivity,uncertainty, and decision analyses in the prioritization of research

The evaluation of hazards from complex, large scale, technologically advanced systems often requires the construction of computer implemented mathematical models. These models are used to evaluate the safety of the systems and to evaluate the consequences of modifications to the systems. These evaluations, however, are normally surrounded by significant uncertainties related to the uncertainty inherent in natural phenomena such as the weather and those related to uncertainties in the parameters and models used in the evaluation.

Another use of these models is to evaluate strategies for improving information used in the modeling process itself. While sensitivity analysis is useful in defining variables in the model that are important, uncertainty analysis provides a tool for assessing the importance of uncertainty about these variables. A third complementary technique, is decision analysis. It provides a methodology for explicitly evaluating and ranking potential improvements to the model. Its use in the development of information gathering strategies for a nuclear waste repository are discussed in this paper.