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31.
转股条款的灵活设计是实现可转债特定融资动因的重要途径之一,本文根据相关理论假说及其对证券条款设计的意义,设计了较为系统的实证分析框架和稳健的模型估计方法,对我国可转债的转股条款进行了较为严格意义上的实证检验。研究发现,高负债率、小规模和获取经营现金能力较差的公司明显倾向于设计较低的转股价格和较高的转换比率;信用记录较短(以上市年限代表)和收益不稳定的公司具有相同的倾向。国内可转债设计主要由财务危机假说解释,而制度性因素对条款设计具有重要影响。总体上,目前可转债的条款设计没有得到发行人的理性对待,本文就此提出了相关政策建议。 相似文献
32.
Marschner IC 《Pharmaceutical statistics》2007,6(1):23-33
Clinical trials are often designed to compare several treatments with a common control arm in pairwise fashion. In this paper we study optimal designs for such studies, based on minimizing the total number of patients required to achieve a given level of power. A common approach when designing studies to compare several treatments with a control is to achieve the desired power for each individual pairwise treatment comparison. However, it is often more appropriate to characterize power in terms of the family of null hypotheses being tested, and to control the probability of rejecting all, or alternatively any, of these individual hypotheses. While all approaches lead to unbalanced designs with more patients allocated to the control arm, it is found that the optimal design and required number of patients can vary substantially depending on the chosen characterization of power. The methods make allowance for both continuous and binary outcomes and are illustrated with reference to two clinical trials, one involving multiple doses compared to placebo and the other involving combination therapy compared to mono-therapies. In one example a 55% reduction in sample size is achieved through an optimal design combined with the appropriate characterization of power. 相似文献
33.
When we want to compare two designs we usually assume the standard linear model with uncorrelated observations. In this paper we use the comparison method proposed by Ghosh & Shen (2006) to compare three level orthogonal arrays with 18, 27 and 36 runs under a possible presence of correlation in observations. 相似文献
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35.
论述了互连网络拓扑优化设计问题,建立了必要的数学模型,该数学模型是一个非线性组合优化问题,它属于NP—完备类问题。采取拉格朗日松弛法、次梯度迭代算法和启发式算法,得出最优下确界和结论。 相似文献
36.
Compliance Strategies and Regulatory Effectiveness of Performance-Based Regulation of Chemical Accident Risks 总被引:2,自引:0,他引:2
This paper investigates the role that performance-based regulations can play in linking a firm's environmental, health, and safety concerns with their corporate strategy. The specific focus is on the performance standards required by the Clean Air Act Amendments (CAAA) which require firms that store or use certain chemicals to develop a Risk Management Plan (RMP) for reducing the likelihood and impact of accidents at their plants. Data from a series of case studies and interviews of executives in chemical firms reveal that proactive companies integrated many of the requirements of the CAAA into their management systems prior to the regulatory requirements. Most of these firms tend to be large ones. Small firms often lack the resources to implement these regulations and hence have tended to have a more difficult time with compliance. 相似文献
37.
The results of a computer search for saturated designs for 2n factorial experiments with n runs is reported, (where n = 2 mod 4). A complete search of the design space is avoided by focussing on designs constructed from cyclic generators. A method of searching quickly for the best generators is given. The resulting designs are as good as, and sometimes better than, designs obtained via search algorithms reported in the literature. The addition of a further factor having three levels is also considered. Here, too, a complete search is avoided by restricting attention to the most efficient part of the design space under p-efficiency. 相似文献
38.
In this paper we define a class of unbalanced designs, denoted by Ck,s,t, for estimating the components of variance in a k-stage nested random effects linear model. This class contains many of the designs proposed in the literature for nested components of variance models. We focus on the three-state model and discuss the determination of locally optimal designs within this class using a systematic computer search. For large sample sizes we show that approximate optimal designs may be obtained using a limit argument combined with numerical optimization. A comparison of our designs with previously published designs suggests that, in many cases, our designs result in substantial gains in efficiency. 相似文献
39.
We consider some computational issues that arise when searching for optimal designs for pharmacokinetic (PK) studies. Special factors that distinguish these are (i) repeated observations are taken from each subject and the observations are usually described by a nonlinear mixed model (NLMM), (ii) design criteria depend on the model fitting procedure, (iii) in addition to providing efficient parameter estimates, the design must also permit model checking, (iv) in practice there are several design constraints, (v) the design criteria are computationally expensive to evaluate and often numerical integration is needed and finally (vi) local optimisation procedures may fail to converge or get trapped at local optima.We review current optimal design algorithms and explore the possibility of using global optimisation procedures. We use these latter procedures to find some optimal designs.For multi-purpose designs we suggest two surrogate design criteria for model checking and illustrate their use. 相似文献
40.
利用MUX级联网络实现多变量逻辑函数时,为求得最简的级联系统,本文提出了利用剩余函数立方图求取变量划分的快速方法。该法无需借助卡诺图,也不需要进行复杂的运算。结果表明,该法行之有效而且十分方便。 相似文献