State transition modeling of complex monitored health data

This article considers the analysis of complex monitored health data, where often one or several signals are reflecting the current health status that can be represented by a finite number of states, in addition to a set of covariates. In particular, we consider a novel application of a non-parametric state intensity regression method in order to study time-dependent effects of covariates on the state transition intensities. The method can handle baseline, time varying as well as dynamic covariates. Because of the non-parametric nature, the method can handle different data types and challenges under minimal assumptions. If the signal that is reflecting the current health status is of continuous nature, we propose the application of a weighted median and a hysteresis filter as data pre-processing steps in order to facilitate robust analysis. In intensity regression, covariates can be aggregated by a suitable functional form over a time history window. We propose to study the estimated cumulative regression parameters for different choices of the time history window in order to investigate short- and long-term effects of the given covariates. The proposed framework is discussed and applied to resuscitation data of newborns collected in Tanzania.     

Generalized empirical likelihood inference in partial linear regression model for longitudinal data

In this paper, empirical likelihood inference for longitudinal data within the framework of partial linear regression models are investigated. The proposed procedures take into consideration the correlation within groups without involving direct estimation of nuisance parameters in the correlation matrix. The empirical likelihood method is used to estimate the regression coefficients and the baseline function, and to construct confidence intervals. A nonparametric version of Wilk's theorem for the limiting distribution of the empirical likelihood ratio is derived. Compared with methods based on normal approximations, the empirical likelihood does not require consistent estimators for the asymptotic variance and bias. The finite sample behaviour of the proposed method is evaluated with simulation and illustrated with an AIDS clinical trial data set.     

Improving variance function estimation in semiparametric longitudinal data analysis

We propose an efficient and robust method for variance function estimation in semiparametric longitudinal data analysis. The method utilizes a local log‐linear approximation for the variance function and adopts a generalized estimating equation approach to account for within subject correlations. We show theoretically and empirically that our method outperforms estimators using working independence that ignores the correlations. The Canadian Journal of Statistics 39: 656–670; 2011. © 2011 Statistical Society of Canada     

Classical testing in functional linear models

We extend four tests common in classical regression – Wald, score, likelihood ratio and F tests – to functional linear regression, for testing the null hypothesis, that there is no association between a scalar response and a functional covariate. Using functional principal component analysis, we re-express the functional linear model as a standard linear model, where the effect of the functional covariate can be approximated by a finite linear combination of the functional principal component scores. In this setting, we consider application of the four traditional tests. The proposed testing procedures are investigated theoretically for densely observed functional covariates when the number of principal components diverges. Using the theoretical distribution of the tests under the alternative hypothesis, we develop a procedure for sample size calculation in the context of functional linear regression. The four tests are further compared numerically for both densely and sparsely observed noisy functional data in simulation experiments and using two real data applications.     

Asymptotic distribution of regression correlation coefficient for Poisson regression model

This study treats an asymptotic distribution for measures of predictive power for generalized linear models (GLMs). We focus on the regression correlation coefficient (RCC) that is one of the measures of predictive power. The RCC, proposed by Zheng and Agresti is a population value and a generalization of the population value for the coefficient of determination. Therefore, the RCC is easy to interpret and familiar. Recently, Takahashi and Kurosawa provided an explicit form of the RCC and proposed a new RCC estimator for a Poisson regression model. They also showed the validity of the new estimator compared with other estimators. This study discusses the new statistical properties of the RCC for the Poisson regression model. Furthermore, we show an asymptotic normality of the RCC estimator.     

大面阵CCD航测相机图像去黑斑的处理

在大面阵数字航测相机的使用过程中,存在影像光照不均匀的问题.由于硬件设计很难达到预想的效果,在光照过于强烈的情况下,还会产生CCD过饱和的现象,通过增加遮光片可以解决这一问题,但全色波段的影像会产生黑斑.而通过马斯克匀光的方法去除中心的黑斑,提高影像的质量.并且将图像中心的反差增大,加大对比度,增大图像灰度的动态范围.     

Updating discriminant functions estimated from inverse gaussian populations

The problem of updating discriminant functions estimated from inverse Gaussian populations is investigated in situations when the additional observations are mixed (unclassified) or classified. In each case two types of discriminant functions, linear and quadratic, are considered. Using simulation experiments the performance of the updating procedures is evaluated by means of relative efficiencies.     

Effect of aggregation on the estimation of trend in mortality

There are three approaches to analyzing and forecasting age‐specific mortality: (1) analyze age‐specific data directly, (2) analyze each cause‐specific mortality series separately and add the results, (3) analyze cause‐specific mortality series jointly and add the results. We show that if linear models are used for cause‐specific mortality, then the three approaches often give close results even when cause‐specific series are correlated. This result holds for cross‐correlations arising from random misclassification of deaths by cause, and also for certain patterns of systematic misclassification. It need not hold, if one or more causes serve as “leading indicators”; for the remaining causes, or if outside information is incorporated into forecasting either through expert judgment or formal statistical modeling. Under highly nonlinear models or in the presence of modeling error the result may also fail. The results are illustrated with U.S. age‐specific mortality data from 1968–1985. In some cases the aggregate forecasts appear to be the more credible ones.     

Causality and interdependence analysis in linear econometric models with an application to fertility

This paper is an applied analysis of the causal structure of linear multi-equational econometric models. Its aim is to identify the kind of relationships linking the endogenous variables of the model, distinguishing between causal links and feedback loops. The investigation is first carried out within a deterministic framework and then moves on to show how the results may change inside a more realistic stochastic context. The causal analysis is then specifically applied to a linear simultaneous equation model explaining fertility rates. The analysis is carried out by means of a specific RATS programming code designed to show the specific nature of the relationships within the model.