Human Salmonellosis: Estimation of Dose-Illness from Outbreak Data

The quantification of the relationship between the amount of microbial organisms ingested and a specific outcome such as infection, illness, or mortality is a key aspect of quantitative risk assessment. A main problem in determining such dose-response models is the availability of appropriate data. Human feeding trials have been criticized because only young healthy volunteers are selected to participate and low doses, as often occurring in real life, are typically not considered. Epidemiological outbreak data are considered to be more valuable, but are more subject to data uncertainty. In this article, we model the dose-illness relationship based on data of 20 Salmonella outbreaks, as discussed by the World Health Organization. In particular, we model the dose-illness relationship using generalized linear mixed models and fractional polynomials of dose. The fractional polynomial models are modified to satisfy the properties of different types of dose-illness models as proposed by Teunis et al . Within these models, differences in host susceptibility (susceptible versus normal population) are modeled as fixed effects whereas differences in serovar type and food matrix are modeled as random effects. In addition, two bootstrap procedures are presented. A first procedure accounts for stochastic variability whereas a second procedure accounts for both stochastic variability and data uncertainty. The analyses indicate that the susceptible population has a higher probability of illness at low dose levels when the combination pathogen-food matrix is extremely virulent and at high dose levels when the combination is less virulent. Furthermore, the analyses suggest that immunity exists in the normal population but not in the susceptible population.     

线性科学与非线性科学哲学思想研究

在简述线性科学的科学基础、科学方法和哲学思想的基础上，研究了非线性科学的科学基础、科学方法和哲学思想，其中较为详细地探讨了非线性科学的哲学范畴和哲学思想，认为要多角度观察事物，要从变化中认识主要矛盾，事物的发展是多元竞争与协同的统一，这一结果将对非线性科学的哲学思想的进一步研究有一定的启发和借鉴作用。     

薪酬策略与公司竞争战略的匹配机制研究

文章通过对185家企业的实地调研,比较了薪酬策略和公司竞争战略的两种匹配模式:中介匹配和调节匹配.否定了中介匹配模式,支持了调节匹配模式,从而解决了薪酬管理研究中长期存在的争议:两者到底是如何匹配的.公司竞争战略并不能自发地促生出相应的薪酬策略,而是需要相关部门较为独立地开发出相应的薪酬策略与之配套.最后,根据研究发现并提出了一些增进薪酬策略与公司竞争战略匹配度的建议.     

图的点星荫度

引入了图的点星荫度的概念,研究了一般图的点星荫度的上界,着重讨论了平面图和外平面图的点星荫度。     

Pseudo–Modelling of Outliers for Estimation of Regression And Time Series Models

This paper documents situations where the variance inflation model for outliers has undesirable properties. The model is commonly used to accommodate outliers in a Bayesian analysis of regression and time series models. The alternative approach provided here does not suffer from these undesirable properties but gives inferences similar to those of the variance inflation model when this is appropriate. It can be used with regression, time series, and regression with correlated errors in a unified way, and adheres to the scientific principle that inference should be based on the data after obvious outliers have been discarded. Only one parameter is required for outliers; it is interpretable as the a priori willingness to remove observations from the analysis.     

Defining the linear portion of a sigmoid‐shaped curve: bend points

Formulae are provided that define the ‘bend points’, the beginning and end of the essentially linear dose–response region, for the four‐parameter logistic model. The formulae are expressed in both response and dose units. The derivation of the formulae is shown in order to illustrate the general nature of the methodology. Examples are given that describe how the formulae may be used while planning and conducting bioassays. Copyright © 2003 John Wiley & Sons, Ltd.     

一类两个相同部件并联的可修系统的稳定性

研究一类两个相同部件并联的可修系统．使用泛函分析方法，特别是Banach空间上的线性算子理论，证明了严格占优本征值的存在性，以及系统解的渐近稳定性，线性稳定性和指数稳定性．     

Semiparametric linear transformation models for current status data

Current status data arise when the death of every subject in a study cannot be determined precisely, but is known only to have occurred before or after a random monitoring time. The authors discuss the analysis of such data under semiparametric linear transformation models for which they propose a general inference procedure based on estimating functions. They determine the properties of the estimates they propose for the regression parameters of the model and illustrate their technique using tumorigenicity data.     

Joint impact of multiple observations on a subset of variables in multiple linear regression

In multiple linear regression analysis, each observation affects the fitted regression equation differently and has varying influences on the regression coefficients of the different variables. Chatterjee & Hadi (1988) have proposed some measures such as DSSE_ij (Impact on Residual Sum of Squares of simultaneously omitting the ith observation and the jth variable), F_j (Partial F-test for the jth variable) and F_j(i) (Partial F-test for the jth variable omitting the ith observation) to show the joint impact and the interrelationship that exists among a variable and an observation. In this paper we have proposed more extended form of those measures DSSE_IJ, F_J and F_J(I) to deal with the interrelationships that exist among the multiple observations and a subset of variables by monitoring the effects of the simultaneous omission of multiple variables and multiple observations.     

有机同系物的一个同系线性规律

对有机同系物的同系线性规律进行了探讨,提出了有机同系物的一种同系线性规律,其表达式为,并用有机共轭体系和双向共轭同系物的光电子能谱数据对该线性规律进行了验证。