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91.
A generalized brick wall model is developed to describe intergranular corrosion in Equi-axed AA7178-T6 and Wingskin AA7178-T6 aluminum alloys. The intergranular corrosion rate is highly related to grain size and shape. High strength aluminum alloys are often elongated and anisotropic, with the fastest nominal IGC growth rate in the longitudinal direction (L) or long transverse direction (T) and the slowest in the short transverse direction (S). We propose a three-way intersection model and use it to simulate the corrosion kinetics for each direction. With a proper combination of model parameters, the generalized IGC model provides a good fit to experimental data developed by the foil penetration technique.  相似文献   
92.
We introduce a new goodness-of-fit test which can be applied to hypothesis testing about the marginal distribution of dependent data. We derive a new test for the equivalent hypothesis in the space of wavelet coefficients. Such properties of the wavelet transform as orthogonality, localisation and sparsity make the hypothesis testing in wavelet domain easier than in the domain of distribution functions. We propose to test the null hypothesis separately at each wavelet decomposition level to overcome the problem of bi-dimensionality of wavelet indices and to be able to find the frequency where the empirical distribution function differs from the null in case the null hypothesis is rejected. We suggest a test statistic and state its asymptotic distribution under the null and under some of the alternative hypotheses.  相似文献   
93.
Parametric incomplete data models defined by ordinary differential equations (ODEs) are widely used in biostatistics to describe biological processes accurately. Their parameters are estimated on approximate models, whose regression functions are evaluated by a numerical integration method. Accurate and efficient estimations of these parameters are critical issues. This paper proposes parameter estimation methods involving either a stochastic approximation EM algorithm (SAEM) in the maximum likelihood estimation, or a Gibbs sampler in the Bayesian approach. Both algorithms involve the simulation of non-observed data with conditional distributions using Hastings–Metropolis (H–M) algorithms. A modified H–M algorithm, including an original local linearization scheme to solve the ODEs, is proposed to reduce the computational time significantly. The convergence on the approximate model of all these algorithms is proved. The errors induced by the numerical solving method on the conditional distribution, the likelihood and the posterior distribution are bounded. The Bayesian and maximum likelihood estimation methods are illustrated on a simulated pharmacokinetic nonlinear mixed-effects model defined by an ODE. Simulation results illustrate the ability of these algorithms to provide accurate estimates.  相似文献   
94.
A general nonparametric imputation procedure, based on kernel regression, is proposed to estimate points as well as set- and function-indexed parameters when the data are missing at random (MAR). The proposed method works by imputing a specific function of a missing value (and not the missing value itself), where the form of this specific function is dictated by the parameter of interest. Both single and multiple imputations are considered. The associated empirical processes provide the right tool to study the uniform convergence properties of the resulting estimators. Our estimators include, as special cases, the imputation estimator of the mean, the estimator of the distribution function proposed by Cheng and Chu [1996. Kernel estimation of distribution functions and quantiles with missing data. Statist. Sinica 6, 63–78], imputation estimators of a marginal density, and imputation estimators of regression functions.  相似文献   
95.
96.
Standard methods of estimation for autoregressive models are known to be biased in finite samples, which has implications for estimation, hypothesis testing, confidence interval construction and forecasting. Three methods of bias reduction are considered here: first-order bias correction, FOBC, where the total bias is approximated by the O(T-1) bias; bootstrapping; and recursive mean adjustment, RMA. In addition, we show how first-order bias correction is related to linear bias correction. The practically important case where the AR model includes an unknown linear trend is considered in detail. The fidelity of nominal to actual coverage of confidence intervals is also assessed. A simulation study covers the AR(1) model and a number of extensions based on the empirical AR(p) models fitted by Nelson & Plosser (1982). Overall, which method dominates depends on the criterion adopted: bootstrapping tends to be the best at reducing bias, recursive mean adjustment is best at reducing mean squared error, whilst FOBC does particularly well in maintaining the fidelity of confidence intervals.  相似文献   
97.
When we want to compare two designs we usually assume the standard linear model with uncorrelated observations. In this paper we use the comparison method proposed by Ghosh & Shen (2006) to compare three level orthogonal arrays with 18, 27 and 36 runs under a possible presence of correlation in observations.  相似文献   
98.
The two experimental methods most commonly used for reducing the effect of noise factors on a response of interest Y aim either to estimate a model of the variability (V(Y), or an associated function), that is transmitted by the noise factors, or to estimate a model of the ratio between the response (Y) and all the control and noise factors involved therein. Both methods aim to determine which control factor conditions minimise the noise factors' effect on the response of interest, and a series of analytical guidelines are established to reach this end. Product array designs allow robustness problems to be solved in both ways, but require a large number of experiments. Thus, practitioners tend to choose more economical designs that only allow them to model the surface response for Y. The general assumption is that both methods would lead to similar conclusions. In this article we present a case that utilises a design based on a product design and for which the conclusions yielded by the two analytical methods are quite different. This example casts doubt on the guidelines that experimental practice follows when using either of the two methods. Based on this example, we show the causes behind these discrepancies and we propose a number of guidelines to help researchers in the design and interpretation of robustness problems when using either of the two methods.  相似文献   
99.
Based on sero-prevalence data of rubella, mumps in the UK and varicella in Belgium, we show how the force of infection, the age-specific rate at which susceptible individuals contract infection, can be estimated using generalized linear mixed models (McCulloch & Searle, 2001). Modelling the dependency of the force of infection on age by penalized splines, which involve fixed and random effects, allows us to use generalized linear mixed models techniques to estimate both the cumulative probability of being infected before a given age and the force of infection. Moreover, these models permit an automatic selection of the smoothing parameter. The smoothness of the estimated force of infection can be influenced by the number of knots and the degree of the penalized spline used. To determine these, a different number of knots and different degrees are used and the results are compared to establish this sensitivity. Simulations with a different number of knots and polynomial spline bases of different degrees suggest - for estimating the force of infection from serological data - the use of a quadratic penalized spline based on about 10 knots.  相似文献   
100.
Estimated associations between an outcome variable and misclassified covariates tend to be biased when the methods of estimation that ignore the classification error are applied. Available methods to account for misclassification often require the use of a validation sample (i.e. a gold standard). In practice, however, such a gold standard may be unavailable or impractical. We propose a Bayesian approach to adjust for misclassification in a binary covariate in the random effect logistic model when a gold standard is not available. This Markov Chain Monte Carlo (MCMC) approach uses two imperfect measures of a dichotomous exposure under the assumptions of conditional independence and non-differential misclassification. A simulated numerical example and a real clinical example are given to illustrate the proposed approach. Our results suggest that the estimated log odds of inpatient care and the corresponding standard deviation are much larger in our proposed method compared with the models ignoring misclassification. Ignoring misclassification produces downwardly biased estimates and underestimate uncertainty.  相似文献   
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