Confidence intervals for secondary parameters following a sequential test

In sequential studies, formal interim analyses are usually restricted to a consideration of a single null hypothesis concerning a single parameter of interest. Valid frequentist methods of hypothesis testing and of point and interval estimation for the primary parameter have already been devised for use at the end of such a study. However, the completed data set may warrant a more detailed analysis, involving the estimation of parameters corresponding to effects that were not used to determine when to stop, and yet correlated with those that were. This paper describes methods for setting confidence intervals for secondary parameters in a way which provides the correct coverage probability in repeated frequentist realizations of the sequential design used. The method assumes that information accumulates on the primary and secondary parameters at proportional rates. This requirement will be valid in many potential applications, but only in limited situations in survival analysis.     

Bootstrap tests: how many bootstraps?

In practice, bootstrap tests must use a finite number of bootstrap samples. This means that the outcome of the test will depend on the sequence of random numbers used to generate the bootstrap samples, and it necessarily results in some loss of power. We examine the extent of this power loss and propose a simple pretest procedure for choosing the number of bootstrap samples so as to minimize experimental randomness. Simulation experiments suggest that this procedure will work very well in practice.     

Recent and classical goodness-of-fit tests for the Poisson distribution

We give a critical synopsis of classical and recent tests for Poissonity, our emphasis being on procedures which are consistent against general alternatives. Two classes of weighted Cramér–von Mises type test statistics, based on the empirical probability generating function process, are studied in more detail. Both of them generalize already known test statistics by introducing a weighting parameter, thus providing more flexibility with regard to power against specific alternatives. In both cases, we prove convergence in distribution of the statistics under the null hypothesis in the setting of a triangular array of rowwise independent and identically distributed random variables as well as consistency of the corresponding test against general alternatives. Therefore, a sound theoretical basis is provided for the parametric bootstrap procedure, which is applied to obtain critical values in a large-scale simulation study. Each of the tests considered in this study, when implemented via the parametric bootstrap method, maintains a nominal level of significance very closely, even for small sample sizes. The procedures are applied to four well-known data sets.     

Nonparametric Tests for Stratum Effects in the Cox Model

Thispaper considers the stratified proportional hazards model witha focus on the assessment of stratum effects. The assessmentof such effects is often of interest, for example, in clinicaltrials. In this case, two relevant tests are the test of stratuminteraction with covariates and the test of stratum interactionwith baseline hazard functions. For the test of stratum interactionwith covariates, one can use the partial likelihood method (Kalbfleischand Prentice, 1980; Lin, 1994). For the test of stratum interactionwith baseline hazard functions, however, there seems to be noformal test available. We consider this problem and propose aclass of nonparametric tests. The asymptotic distributions ofthe tests are derived using the martingale theory. The proposedtests can also be used for survival comparisons which need tobe adjusted for covariate effects. The method is illustratedwith data from a lung cancer clinical trial.     

A Weighted Least Squares Approach to Levene's Test of Homogeneity of Variance

In 1960 Levene suggested a potentially robust test of homogeneity of variance based on an ordinary least squares analysis of variance of the absolute values of mean-based residuals. Levene's test has since been shown to have inflated levels of significance when based on the F-distribution, and tests a hypothesis other than homogeneity of variance when treatments are unequally replicated, but the incorrect formulation is now standard output in several statistical packages. This paper develops a weighted least squares analysis of variance of the absolute values of both mean-based and median-based residuals. It shows how to adjust the residuals so that tests using the F -statistic focus on homogeneity of variance for both balanced and unbalanced designs. It shows how to modify the F -statistics currently produced by statistical packages so that the distribution of the resultant test statistic is closer to an F-distribution than is currently the case. The weighted least squares approach also produces component mean squares that are unbiased irrespective of which variable is used in Levene's test. To complete this aspect of the investigation the paper derives exact second-order moments of the component sums of squares used in the calculation of the mean-based test statistic. It shows that, for large samples, both ordinary and weighted least squares test statistics are equivalent; however they are over-dispersed compared to an F variable.     

计算机辅助英语阅读课程设计的若干问题

本文从计算机辅助语言学习（ Ｃ Ａ Ｌ Ｌ） 课程的设计思想出发,分析和讨论有关机助英语阅读课程设计的若干问题,如阅读能力,教学方法,学习的评价等,以揭示机助英语阅读课程乃至机助语言学习课程设计的一些规律和原则     

大学英语听力教学管见

大学生在国家四、六级统考中表现出来的薄弱环节是听力差。本文从听力过程、影响听力的因素和图式理论的角度对大学英语听力教学进行了探讨,提出了听前导入、听音训练、口头反馈的听力教学模式     

中国制造业集聚：度量与显著性检验 ——基于集聚测量新方法

 根据集聚分布的自身特点,本文提出了可以进行显著性检验的普适性产业集聚指数,并对我国28制造业1994年的860个样本和2004年800个样本进行测量和检验,我们的计算结果表明,中国制造业的集聚强度总体上呈上升趋势,同时具有集聚和扩散双重现象。     

Local Power Analyses of Goodness-of-fit Tests for Copulas

Abstract.  The asymptotic behaviour of several goodness-of-fit statistics for copula families is obtained under contiguous alternatives. Many comparisons between a Cramér–von Mises functional of the empirical copula process and new moment-based goodness-of-fit statistics are made by considering their associated asymptotic local power curves. It is shown that the choice of the estimator for the unknown parameter can have a significant influence on the power of the Cramér–von Mises test and that some of the moment-based statistics can provide simple and efficient goodness-of-fit methods.