Consultants' forum: should post hoc sample size calculations be done?

Pre‐study sample size calculations for clinical trial research protocols are now mandatory. When an investigator is designing a study to compare the outcomes of an intervention, an essential step is the calculation of sample sizes that will allow a reasonable chance (power) of detecting a pre‐determined difference (effect size) in the outcome variable, at a given level of statistical significance. Frequently studies will recruit fewer patients than the initial pre‐study sample size calculation suggested. Investigators are faced with the fact that their study may be inadequately powered to detect the pre‐specified treatment effect and the statistical analysis of the collected outcome data may or may not report a statistically significant result. If the data produces a “non‐statistically significant result” then investigators are frequently tempted to ask the question “Given the actual final study size, what is the power of the study, now, to detect a treatment effect or difference?” The aim of this article is to debate whether or not it is desirable to answer this question and to undertake a power calculation, after the data have been collected and analysed. Copyright © 2008 John Wiley & Sons, Ltd.     

Back to basics: explaining sample size in outcome trials,are statisticians doing a thorough job?

Time to event outcome trials in clinical research are typically large, expensive and high‐profile affairs. Such trials are commonplace in oncology and cardiovascular therapeutic areas but are also seen in other areas such as respiratory in indications like chronic obstructive pulmonary disease. Their progress is closely monitored and results are often eagerly awaited. Once available, the top line result is often big news, at least within the therapeutic area in which it was conducted, and the data are subsequently fully scrutinized in a series of high‐profile publications. In such circumstances, the statistician has a vital role to play in the design, conduct, analysis and reporting of the trial. In particular, in drug development it is incumbent on the statistician to ensure at the outset that the sizing of the trial is fully appreciated by their medical, and other non‐statistical, drug development team colleagues and that the risk of delivering a statistically significant but clinically unpersuasive result is minimized. The statistician also has a key role in advising the team when, early in the life of an outcomes trial, a lower than anticipated event rate appears to be emerging. This paper highlights some of the important features relating to outcome trial sample sizing and makes a number of simple recommendations aimed at ensuring a better, common understanding of the interplay between sample size and power and the final result required to provide a statistically positive and clinically persuasive outcome. Copyright © 2009 John Wiley & Sons, Ltd.     

The matched pair sign test using bivariate ranked set sampling for different ranking based schemes

Bivariate rank set sample (BVRSS) matched pair sign test is introduced and investigated for different ranking based schemes. We show that this test is asymptotically more efficient and more powerful than its counterpart sign test based on a bivariate simple random sample (BVSRS) for different ranking schemes. The asymptotic null distribution and the efficiency of the test are derived. Pitman’s asymptotic relative efficiency is used to compare the asymptotic performance of the matched pair sign test using BVRSS versus using BVSRS in all ranking cases. For small sample sizes, the bootstrap method is used to estimate P-values. Numerical comparisons are used to gain insight about the efficiency of the BVRSS sign test compared to the BVSRS sign test. Our numerical and theoretical results indicate that using any ranking scheme of BVRSS for the matched pair sign test is more efficient than using BVSRS.     

A new nonparametric bivariate test for two sample location problem

A strictly nonparametric bivariate test for two sample location problem is proposed. The proposed test is easy to apply and does not require the stringent condition of affine-symmetry or elliptical symmetry which is required by some of the major tests available for the same problem. The power function of the proposed test is calculated. The asymptotic distribution of the proposed test statistic is found to be normal. The power of proposed test is compared with some of the well-known tests under various distributions using Monte Carlo simulation technique. The power study shows that the proposed test statistic performs better than most of the test statistics for almost all the distributions considered here. As soon as the underlying population structure deviates from normality, the ability of the proposed test statistic to detect the smallest shift in location increases as compared to its competitors. The application of the test is shown by using a data set.     

青岛一套表的实践与经验

 企业统计一套表一直是统计制度方法改革和实践中的焦点问题。本文通过对青岛市统计局企业一套表制度实施情况的案例分析，系统界定了企业一套表的概念和内涵，全面展现了企业一套表的运作过程，客观分析了制约企业一套表实施的主要原因，并提出了在现阶段实施企业统计一套表的条件和要求。     

A powerful test for uniformity to detect highly peaked alternativedensities

A new class of statistical tests for uniformity based on sample ranges is proposed to detect a uniform density contaminated by a density with one or more high peaks. These kinds of alternatives occur quite frequently, especially in physics. It is shown that the proposed tests arc consistent and have high Pitman asymptotic relative efficiencies. Results of a Monte Carlo power study indicate that they, compared with other tests of uniformity, possess good power properties.A comparative study of various tests is also conducted using real data. An effcient algorithm for computing out test statistic and a table of percentage points are given, providing a practical guide for using the new test.     

浅析大学生心理压力的现状与对策

以自编大学生心理压力调查问卷为工具,从大学生对自身心理压力的认知、大学生心理压力产生的根源、大学生心理压力缓解的途径、大学生对心理压力产生原因的认识、大学生对心理压力的归因等方面揭示大学生心理压力的现状,并提出相应的应对策略。     

Sex segregation in India's formal manufacturing sector

Using an index of dissimilarity based on data from the Annual Survey of Industries for 1989/90 and 2000/01, the authors find that sex segregation across India's so‐called factory sector decreased over this period. Most of the apparent improvement, however, was due to changes in the industrial structure of employment, not desegregation per se. The index is also sensitive to the number of industries in the underlying classifications. At the national and state levels, formal job opportunities for women are effectively very limited: they are highly concentrated in a small number of traditional “women's” manufacturing industries, such as food, tobacco, apparel, weaving and spinning.     

Planners’ Perceptions of Why Canadian Communities Have Too Many Plans

A survey of Canadian planners explored perceptions about factors contributing to the growing number of plans communities have adopted recently. The results suggest that practitioners see themselves as responding to current community concerns, as well as to requirements imposed by higher levels of government. Neoliberal practices that force compliance with accountability frameworks to enable transfer payments increase demands for new plans. Professional practices within planning have encouraged specialization—in fields such as urban design—that often leads to plan-making activities. With many plans to coordinate, and limited staff resources and time available, practitioners face increasing implementation challenges.     

Universal versus contextual effects on TQM: a triangulation study using neural networks

The objective of this study is to extend previous research on total quality management (TQM)-context-performance relationships and ‘fit’ using multiple methods. We combine artificial neural networks (ANNs) with structural equation modelling (SEM) to analyse several hypotheses and propositions. This is the first study in this area of research that utilises ANNs and a triangulation technique in the presence of several contextual factors. The SEM analyses suggest that company size and industry type may have contingency effects on some of the TQM practices and/or TQM-performance relationships. However, the ANN models have shown that these two contingency factors do not moderate TQM outcomes, implying that all organisations can benefit from TQM regardless of size and type. As well, these models show that formal TQM implementation and/or ISO certifications do not add any predictive power to the ANN models except in one case: TQM implementation and/or ISO certification added to organisational effectiveness and customer results to predict financial and market (F&M) results. The results further indicate that even though implementing TQM alone has a bigger impact on F&M results than obtaining ISO certification alone, combining the two will have an even greater impact on these results. Joint implementation leads to greater improvements in organisational effectiveness, which, in turn, has a positive effect on customer results and consequently F&M results. This is a unique finding within the context of moderator effects on TQM-performance relationships.