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71.
Edward C. Stewart 《Journal of Social Distress and the Homeless》1995,4(3):163-202
During the 1960s, the new generation changed the American Creed by deemphasizing sensitivity to evidence, emphasizing feelings and deductive thought, while assuming an adversarial position against the sociopolitical order and embracing the American Black's struggle against racism. Driven by pain, fueled by fear and anger and oriented by existential values of being, the Civil Rights Movement, sought to actualize political values of justice and equality. As peaceful demonstrations dwindled, violence increased, converting individual anger to social rage. Anger's cognitive structure changed the concept of society into a dichotomy of Black victims and White oppressors, forming an ethic of sensitivity with victims occupying the moral high ground. Pain and tragedy were banished from view and blamed on oppressors as individual identities divested civil traits and acquired cultural identity, disuniting the civil society. Rubbing against the American Creed, the ethic of sensitivity produced a feeling of malaise posing a threat to mental health. 相似文献
72.
Interspecies scaling factors (ISFs) are numbers used to adjust the potency factor (for example, the q1* for carcinogens or reference doses for compounds eliciting other toxic endpoints) determined in experimental animals to account for expected differences in potency between test animals and people. ISFs have been developed for both cancer and non-cancer risk assessments in response to a common issue: toxicologists often determine adverse effects of chemicals in test animals and then they, or more commonly risk assessors and risk managers, have to draw inferences about what these observations mean for the human population. This perspective briefly reviews the development of ISFs and their applications in health risk assessments over the past 20 years, examining the impact of pharmacokinetic principles in altering current perceptions of the ISFs applied in these health risk assessments, and assessing future directions in applying both pharmacokinetic and pharmacodynamic principles for developing ISFs. 相似文献
73.
D. Szatmari-Voicu 《统计学通讯:理论与方法》2013,42(11):2037-2048
The median absolute deviation (MAD) is known to be the M-estimator of scale with minimum gross errors sensitivity (GES) when the error distribution is known to be symmetric and strongly unimodal. The problem considered here is to find the Fisher consistent M-estimator with minimum GES when the error distribution is symmetric but not necessarily unimodal. Under some general conditions, the score function χ corresponding to the minimizing M-estimator has the form χ(x) = ?1 when |x| < a; χ(x) = c when a < |x| < b; χ(x) = 1 when |x| > b. An example is given in which the M-estimator with minimum GES does not correspond to the MAD. 相似文献
74.
James C. Spall 《统计学通讯:理论与方法》2013,42(12):3747-3762
An approximation is presented that can be used to gain insight into the characteristics – such as outlier sensitivity, bias, and variability – of a wide class of estimators, including maximum likelihood and least squares. The approximation relies on a convenient form for an arbitrary order Taylor expansion in a multivariate setting. The implicit function theorem can be used to construct the expansion when the estimator is not defined in closed form. We present several finite-sample and asymptotic properties of such Taylor expansions, which are useful in characterizing the difference between the estimator and the expansion. 相似文献
75.
Paul R Rosenbaum 《统计学通讯:理论与方法》2013,42(11):2687-2698
In many experiments where data have been collected at two points in time (pre-treatment and post-treatment), investigators wish to determine if there is a difference between two treatment groups. In recent years it has been proposed that an appropriate statistical analysis to determine if treatment differences exist is to use the post-treatment values as the primary comparison variables and the pre-treatment values as covariates. When there are several outcome variables, we propose new tests based on residuals as alternatives to existing methods and investigate how the powers of the new and existing tests are affected by various choices of covariates. The limiting distribution of the test statistic of the new test based on residuals is given. Monte Carlo simulations are employed in the power comparisons. 相似文献
76.
The objective of this research was to demonstrate a framework for drawing inference from sensitivity analyses of incomplete longitudinal clinical trial data via a re‐analysis of data from a confirmatory clinical trial in depression. A likelihood‐based approach that assumed missing at random (MAR) was the primary analysis. Robustness to departure from MAR was assessed by comparing the primary result to those from a series of analyses that employed varying missing not at random (MNAR) assumptions (selection models, pattern mixture models and shared parameter models) and to MAR methods that used inclusive models. The key sensitivity analysis used multiple imputation assuming that after dropout the trajectory of drug‐treated patients was that of placebo treated patients with a similar outcome history (placebo multiple imputation). This result was used as the worst reasonable case to define the lower limit of plausible values for the treatment contrast. The endpoint contrast from the primary analysis was ? 2.79 (p = .013). In placebo multiple imputation, the result was ? 2.17. Results from the other sensitivity analyses ranged from ? 2.21 to ? 3.87 and were symmetrically distributed around the primary result. Hence, no clear evidence of bias from missing not at random data was found. In the worst reasonable case scenario, the treatment effect was 80% of the magnitude of the primary result. Therefore, it was concluded that a treatment effect existed. The structured sensitivity framework of using a worst reasonable case result based on a controlled imputation approach with transparent and debatable assumptions supplemented a series of plausible alternative models under varying assumptions was useful in this specific situation and holds promise as a generally useful framework. Copyright © 2012 John Wiley & Sons, Ltd. 相似文献
77.
The interval-censored survival data appear very frequently, where the event of interest is not observed exactly but it is only known to occur within some time interval. In this paper, we propose a location-scale regression model based on the log-generalized gamma distribution for modelling interval-censored data. We shall be concerned only with parametric forms. The proposed model for interval-censored data represents a parametric family of models that has, as special submodels, other regression models which are broadly used in lifetime data analysis. Assuming interval-censored data, we consider a frequentist analysis, a Jackknife estimator and a non-parametric bootstrap for the model parameters. We derive the appropriate matrices for assessing local influence on the parameter estimates under different perturbation schemes and present some techniques to perform global influence. 相似文献
78.
Jonas Sundell Ezra Haaf Tommy Norberg Claes Aln Mats Karlsson Lars Rosn 《Risk analysis》2019,39(1):105-124
Groundwater leakage into subsurface constructions can cause reduction of pore pressure and subsidence in clay deposits, even at large distances from the location of the construction. The potential cost of damage is substantial, particularly in urban areas. The large‐scale process also implies heterogeneous soil conditions that cannot be described in complete detail, which causes a need for estimating uncertainty of subsidence with probabilistic methods. In this study, the risk for subsidence is estimated by coupling two probabilistic models, a geostatistics‐based soil stratification model with a subsidence model. Statistical analyses of stratification and soil properties are inputs into the models. The results include spatially explicit probabilistic estimates of subsidence magnitude and sensitivities of included model parameters. From these, areas with significant risk for subsidence are distinguished from low‐risk areas. The efficiency and usefulness of this modeling approach as a tool for communication to stakeholders, decision support for prioritization of risk‐reducing measures, and identification of the need for further investigations and monitoring are demonstrated with a case study of a planned tunnel in Stockholm. 相似文献
79.
Robert B. Gramacy 《The American statistician》2020,74(1):87-92
ABSTRACTGames can be a powerful tool for learning about statistical methodology. Effective game design involves a fine balance between caricature and realism, to simultaneously illustrate salient concepts in a controlled setting and serve as a testament to real-world applicability. Striking that balance is particularly challenging in response surface and design domains, where real-world scenarios often play out over long time scales, during which theories are revised, model and inferential techniques are improved, and knowledge is updated. Here, I present a game, borrowing liberally from one first played over 40 years ago, which attempts to achieve that balance while reinforcing a cascade of topics in modern nonparametric response surfaces, sequential design, and optimization. The game embeds a blackbox simulation within a shiny app whose interface is designed to simulate a realistic information–availability setting, while offering a stimulating, competitive environment wherein students can try out new methodology, and ultimately appreciate its power and limitations. Interface, rules, timing with course material, and evaluation are described, along with a “case study” involving a cohort of students at Virginia Tech. Supplementary materials for this article are available online. 相似文献
80.
Individuals differ in their sensitivity toward injustice. Justice‐sensitive persons perceive injustice more frequently and show stronger responses to it. Justice sensitivity has been studied predominantly in adults; little is known about its development in childhood and adolescence and its connection to prosocial behavior and emotional and behavioral problems. This study evaluates a version of the justice sensitivity inventory for children and adolescents (JSI‐CA5) in 1472 9‐ to 17‐year olds. Items and scales showed good psychometric properties and correlations with prosocial behavior and conduct problems similar to findings in adults, supporting the reliability and validity of the scale. We found individual differences in justice sensitivity as a function of age and gender. Furthermore, justice sensitivity predicted emotional and behavioral problems in children and adolescents over a 1‐ to 2‐year period. Justice sensitivity perspectives can therefore be considered as risk and/or protective factors for mental health in childhood and adolescence. 相似文献