An improved comorbidity summary score for measuring disease burden and predicting mortality with applications to two national cohorts

Abstract

Research involving administrative healthcare data to study patient outcomes requires the investigator to account for the patient’s disease burden in order to reduce the potential for biased results. Here we develop a comorbidity summary score based on variable importance measures derived from several statistical and machine learning methods and show it has superior predictive performance to the Elixhauser and Charlson indices when used to predict 1-year, 5-year, and 10-year mortality. We used two large Veterans Administration cohorts to develop and validate the summary score and compared predictive performance using the area under ROC curve (AUC) and the Brier score.     

On Redundancy Allocation to Series and Parallel Systems of Two Components

Abstract

For two components and one standby redundancy, we develop a characterization on the hazard rate order and the reversed hazard rate order of the redundant system lifetime in the context of mutually independent components lifetimes. Also, the likelihood ratio order is derived on the lifetime of the series system with two components lifetimes and two matched active redundancies lifetimes both following the proportional hazard model.     

Accuracy,confidence and consensus in bayesian hypothesis inference

Interest centres on a group of statisticians , each supplied with the same n sample datapoint sandmaking formal Bayesian inference with a common likelihood function but differing prior knowledge and utility functions.

Definitions are proposed which quantify, in a commensurable way, the inference processes of “accuracy”, “confidence” and “consensus” for the case of hypothesis inference with a fixed sample size n.

The general significance of comparing the three quantifiers is considered. As n increases the asymptotic behaviour of the quantifiers is evaluated and it is found that the three rates of convergence are of the same order as a function of n. The results are interpreted and some of their implications are discussed.     

A prior-valued estimator applied to multinomial classification

A multinomial classification rule is proposed based on a prior-valued smoothing for the state probabilities. Asymptotically, the proposed rule has an error rate that converges uniformly and strongly to that of the Bayes rule. For a fixed sample size the prior-valued smoothing is effective in obtaining reason¬able classifications to the situations such as missing data. Empirically, the proposed rule is compared favorably with other commonly used multinomial classification rules via Monte Carlo sampling experiments     

Estimation of the parameters of a regression model with a multivariate t error variable

This paper deals with a regression model for several vari¬ables under the assumption that the errors have a multivariate t-distribution. The parameters of the model, the regression parameters, as well as the scale parameters and the degress of freedom of the error variable are estimated and the estimation procedure is illustrated by a numerical example, Also, the prop¬erties of the estimators and tests for the regression parameters are discussed.     

Bayes estimators of the average failure rates

In the present paper we have proposed a Bayesian approach for making inferences from accelerated life tests which do not require distributional assumptions     

On the asymptotic distribution of an estimate of the change point in a failure rate

The failure rate r(t) is assumed to have the shape of the"first"part of the"bathtub"model, i.e.r(t) is non-increasing for t<r and is constant for t> r. Asymptotic distribution of one of the estimates proposed earlier has been investigated in this paper. This leads to a test for the hypothesis HQ r<r ₀ vs H :r>r (where TQ > 0). Asymptotic expression for the power of this test under Pitman alternatives is derived. Some simulations are reported.     

A Similarity Measure Based on Species Proportions

ABSTRACT

There are several indices for measuring the similarity of two populations, including the ratio of the number of shared species to the number of distinct species (Jaccard's index) and the conditional probability of observing a shared species (Smith et al., 1996 Smith , W. , Solow , A. R. , Preston , P. E. ( 1996 ). An estimator of species overlap using a modified beta-binomial model. Biometrics 52 : 1472 – 1477 . [CSA] [CROSSREF] [Crossref], [Web of Science ®] , [Google Scholar]). However, these indices only take into account the number of species and species proportions of shared species. In this article, we propose a new similarity index which includes the species proportions of both the shared and non shared species in each population, and also propose a Nonparametric Maximum Likelihood Estimator (NPMLE) for this index. Bootstrap and delta methods are used to evaluate the standard errors of the NPMLE. Based on a loss function, we also compare a class of nonparametric estimators for the proposed index in various situations.     

Convergence rates for empirical bayes estimators of parameters in multi-parameter exponential families

This paper obtains the convergence rates of the empirical Bayes estimators of parameters in the multi-parameter exponential families. The rates can approximate to 0(n=¹) arbitrarily. The paper presents the multivariate orthogonal polynomials which are continuous on the total space R^p.