A modified random-effect procedure for combining risk difference in sets of 2×2 tables from clinical trials

Summary Meta-analyses of sets of clinical trials often combine risk differences from several 2×2 tables according to a random-effects model. The DerSimonian-Laird random-effects procedure, widely used for estimating the populaton mean risk difference, weights the risk difference from each primary study inversely proportional to an estimate of its variance (the sum of the between-study variance and the conditional within-study variance). Because those weights are not independent of the risk differences, however, the procedure sometimes exhibits bias and unnatural behavior. The present paper proposes a modified weighting scheme that uses the unconditional within-study variance to avoid this source of bias. The modified procedure has variance closer to that available from weighting by ideal weights when such weights are known. We studied the modified procedure in extensive simulation experiments using situations whose parameters resemble those of actual studies in medical research. For comparison we also included two unbiased procedures, the unweighted mean and a sample-size-weighted mean; their relative variability depends on the extent of heterogeneity among the primary studies. An example illustrates the application of the procedures to actual data and the differences among the results. This research was supported by Grant HS 05936 from the Agency for Health Care Policy and Research to Harvard University.     

具体应用中的矛盾分析法之种种

矛盾分析法在科学认识中的具体应用,可作多侧面的展开,形成多方面的更为具体的科学方法。这些具体科学方法可概括为,矛盾的定性分析法、矛盾的定位分析法、矛盾的定点分析法、矛盾的定量分析法、矛盾的定势分析法、矛盾的历史过程分析法、矛盾的逻辑过程分析法、矛盾的系统分析法、矛盾的对立面互补分析法等等.它们均体现哲学方法与具体科学方法的一致性。     

A study of simulated annealing and a revised cascade algorithm for image reconstruction

We describe an image reconstruction problem and the computational difficulties arising in determining the maximum a posteriori (MAP) estimate. Two algorithms for tackling the problem, iterated conditional modes (ICM) and simulated annealing, are usually applied pixel by pixel. The performance of this strategy can be poor, particularly for heavily degraded images, and as a potential improvement Jubb and Jennison (1991) suggest the cascade algorithm in which ICM is initially applied to coarser images formed by blocking squares of pixels. In this paper we attempt to resolve certain criticisms of cascade and present a version of the algorithm extended in definition and implementation. As an illustration we apply our new method to a synthetic aperture radar (SAR) image. We also carry out a study of simulated annealing, with and without cascade, applied to a more tractable minimization problem from which we gain insight into the properties of cascade algorithms.     

光纤扭转对循环延迟线偏振控制系统特性影响的研究

借助模式耦合理论和矩阵光学的知识,对引入光纤扭转机构后的延迟线偏振控制系统的偏振转换特性进行了分析,推导出了描述该系统偏振特性的琼斯矩阵,得到了光纤扭转对系统偏振特性影响的理论模型。     

关于线性互补问题的迭代算法

建立了一类求解线性互补问题的迭代算法。在一定条件下,研究了保证原问题的解存在唯一的充分条件,并且证明了新算法的收敛性。     

分析Chiral分层媒质特性的一般方法(英文)

提出了一套系统方法用于求解任意导体片位于界面的Chiral分层媒质的谐振频率,衰减因子和电磁场分布。文中的分析是在Fourier变换域的并矢格林函数和矩阵分析的基础上来进行的,给出的公式的最大价值在于它提供了求解Chiral分层媒质问题的方法论。     

金属垂直安定面的后向散射分析

采用射线跟踪和等效电流等方法计算金属垂直安定面的后向散射场和后向散射截面积(RCS)。对TM入射和TE入射在不同的入射角下求得数值结果。仔细分析了外形对后向RCS的影响,并提出压缩后向RCS的措施。     

生理学模块教学改革初探

传统教学方法对教师和学生造成束缚,而模块式教学体现了以人为本的教学思想.在生理学理论和实验课的教学过程中,我们采用了模块式教学,尤其在实验教学中,增加了设计性实验模块.模块教学的实施和考核,注重对学生能力的培养,做到学以致用,为学习者提供了思维的空间和实践的新天地,调动了他们的积极性、主动性.     

主位与主题——界定与分歧

主位-述位理论是马泰休斯(Mathesius)于1939年提出。至今为止,国内外学者已在此理论基础上进行了多方位研究。本文剖析了不同的主位思想和相关理论研究,指明了存在的分歧与问题。     

成长的感悟——析青年作曲家张朝的《变奏曲》

从音乐形态、表现手法等方面具体分析《变奏曲》这部钢琴作品,探究其中对中国传统戏曲效果的模拟,以及作者如何巧妙地借鉴皮黄丰富的音响和表现力并运用到钢琴音乐中。中西的结合,古今的碰撞、鲜明的色彩个性,这些特点使得这部作品成为探索中国钢琴音乐民族化道路上的闪光点。