Administration of daily 5 mg tadalafil improves endothelial function in patients with benign prostatic hyperplasia

Introduction: Tadalafil is a promising phosphodiesterase (PDE) 5 inhibitor prescribed for erectile dysfunction (ED). Daily low dose (5?mg) of tadalafil has also been used for the treatment of male lower urinary tract symptoms (LUTS) associated with benign prostate hyperplasia (BPH). PDE5 inhibitors induce relaxation of smooth muscle cells in the urethra, prostate, bladder neck, and blood vessels. The aim of this study was to investigate the efficacy of tadalafil on vessels endothelial function, in patients with male LUTS symptoms associated with BPH.

Methods: The Institutional Review Board (IRB) approved this clinical study and informed consents had been obtained from 81 BPH patients.

The following male LUTS parameters: international prostate symptom score (IPSS), overactive bladder symptom score (OABSS), voiding volume, max and mean voiding flow on voiding flowmetry examination and post-voiding residual urine (RU) were compared at 0, 1, 3, 6, and 12 months after a daily dose of 5?mg tadalafil.

In addition, erectile function was evaluated by the sexual health inventory for men (SHIM) score and vessels endothelial function and peripheral neuropathy were assessed by the brachial-ankle pulse wave velocity (baPWV), ankle brachial index (ABI), and vibration perception threshold (VPT) at 0, 3, 6, and 12 months after treatment.

Results: The mean age of 81 patients was 66.4?±?11.4 years old. Their prostate size was 30.2?±?22.1?ml.

Male LUTS parameters including IPSS, OABSS, and RU showed significant improvement from 1 to 12 months after tadalafil administration. Max and mean voiding flow was significantly increased at 6 months after tadalafil treatment.

The SHIM score showed significant improvement after 3 months. Whilst, the results of baPWV also showed significant improvement from 3 to 12 months. ABI was also significantly improved at 6 months. However, there was no change in the VPT at any time point.

Conclusions: Tadalafil is effective for both male LUTS and ED. It is also shown that tadalafil improves baPWV, which we can conclude that higher vessels elasticity has been obtained. This major finding of this study shows that tadalafil has the potency to improve vessels endothelial dysfunction in patients with BPH.     

Perceived Inflation Persistence

This article constructs and estimates a measure called perceived inflation persistence that can be used to determine if professional forecasters’ inflation forecasts indicate there has been a change in inflation persistence. This measure is built via the implied autocorrelation function that follows from the estimates obtained using a forecaster-specific state-space model. Findings indicate that U.S. perceived inflation persistence has changed since the mid-1990s with more consensus among forecasters at lower levels of persistence. When compared to the autocorrelation function for actual inflation, forecasters typically react less to shocks to inflation than the actual inflation data would suggest.     

Exact distributions of two non-central generalized Wilks's statistics

We derive the exact expressions of the probability density function (pdf) and the cumulative distribution function (cdf) of Wilks's likelihood ratio criterion Λ and Wilks-Lawley's statistic U in the non-central linear and the non-central planar cases. Those expressions are given in rapidly converging infinite series and can be used for numerical computation. For applications, we compute the exact power of these statistics in a multivariate analysis of variance exercise, and show by simulation the precision of our analytic formulae.     

A general central limit theorem and a subsampling variance estimator for α‐mixing point processes

We establish a central limit theorem for multivariate summary statistics of nonstationary α‐mixing spatial point processes and a subsampling estimator of the covariance matrix of such statistics. The central limit theorem is crucial for establishing asymptotic properties of estimators in statistics for spatial point processes. The covariance matrix subsampling estimator is flexible and model free. It is needed, for example, to construct confidence intervals and ellipsoids based on asymptotic normality of estimators. We also provide a simulation study investigating an application of our results to estimating functions.     

基于犹豫直觉模糊语言集均值-标准差偏好距离的多属性决策研究

在犹豫直觉模糊语言集和语言尺度函数的基础上定义了均值-标准差偏好的Hamming距离，并提出了基于犹豫直觉模糊语言集距离TOPSIS和TODIM的多属性决策方法，进一步利用这两种方法对实例问题建筑商的招标方案进行排序，并讨论了偏好参数对排序结果的灵敏度分析。为验证上述方法的有效性，与已有方法对同一实例的排序结果进行了比较分析。     

Infill asymptotics for adaptive kernel estimators of spatial intensity

We apply the Abramson principle to define adaptive kernel estimators for the intensity function of a spatial point process. We derive asymptotic expansions for the bias and variance under the regime that n independent copies of a simple point process in Euclidean space are superposed. The method is illustrated by means of a simple example and applied to tornado data.     

On the estimation of non linear functions in stochastic volatility models

Abstract

This paper focuses on the inference of suitable generally non linear functions in stochastic volatility models. In this context, in order to estimate the variance of the proposed estimators, a moving block bootstrap (MBB) approach is suggested and discussed. Under mild assumptions, we show that the MBB procedure is weakly consistent. Moreover, a methodology to choose the optimal length block in the MBB is proposed. Some examples and simulations on the model are also made to show the performance of the proposed procedure.     

Children’s narrative story stem responses: Contributions of executive functioning and language proficiency to relationship representations

Story stem narrative tasks provide insight into young children's inner experiences. Little research has investigated how developmental capacities impact narrative content and process. This study evaluates the influence of executive functioning (EF) and language ability on children's narratives. Data were gathered from 210 low‐income children. EF and language ability were assessed at age 4 and EF was assessed at age 6 via direct examination, cognitive‐motor tasks, and examiner ratings. Children's responses to eight story stems were gathered at age 6; three latent narrative variables were constructed (Prosocial, Aggressive/Conflict, and Avoidance/Danger), and Narrative Coherence was rated. Results of longitudinal path analyses in structural equation modeling demonstrated age 4 EF significantly predicted all narrative outcomes. Language ability independently predicted Prosocial and Narrative Coherence, and had an influence on Aggression/Conflict when modeled with EF. Age 6 EF mediated the relationship between age 4 EF and narrative outcomes. Findings provide insight into developmental abilities that influence on children's narrative responses to challenging interpersonal scenarios. Future research should study parent–child relations, EF, and language abilities simultaneously.