Adaptive and repeated cumulative meta‐analyses of safety data during a new drug development process

During a new drug development process, it is desirable to timely detect potential safety signals. For this purpose, repeated meta‐analyses may be performed sequentially on accumulating safety data. Moreover, if the amount of safety data from the originally planned program is not enough to ensure adequate power to test a specific hypothesis (e.g., the noninferiority hypothesis of an event of interest), the total sample size may be increased by adding new studies to the program. Without appropriate adjustment, it is well known that the type I error rate will be inflated because of repeated analyses and sample size adjustment. In this paper, we discuss potential issues associated with adaptive and repeated cumulative meta‐analyses of safety data conducted during a drug development process. We consider both frequentist and Bayesian approaches. A new drug development example is used to demonstrate the application of the methods. Copyright © 2015 John Wiley & Sons, Ltd.     

基于组合赋权UM的煤炭企业人员流失风险评价

针对煤炭企业人员流失风险的复杂性和不确定性,建立了基于组合赋权未确知测度(UM)的综合评价模型。在应用AHM-信息熵确定风险评价因素权重的基础上,采用未确知测度方法对煤炭企业内不同职能的人力资源进行分析,评价出风险等级。最后运用实例证明了组合赋权的有效性和评价模型的可靠性,为企业的风险管理提供决策依据。     

Noninformative priors for linear combinations of normal means with unequal variances

For normal populations with unequal variances, we develop matching priors and reference priors for a linear combination of the means. Here, we find three second-order matching priors: a highest posterior density (HPD) matching prior, a cumulative distribution function (CDF) matching prior, and a likelihood ratio (LR) matching prior. Furthermore, we show that the reference priors are all first-order matching priors, but that they do not satisfy the second-order matching criterion that establishes the symmetry and the unimodality of the posterior under the developed priors. The results of a simulation indicate that the second-order matching prior outperforms the reference priors in terms of matching the target coverage probabilities, in a frequentist sense. Finally, we compare the Bayesian credible intervals based on the developed priors with the confidence intervals derived from real data.     

无产阶级政权建设规律的初步探索

马克思从揭示人类社会发展规律的角度,通过对世界上第一次出现的无产阶级政权——巴黎公社的分析和总结,阐述了科学社会主义政权建设理论,提出了一些基本政治原则。他指出:建立一个真正的人民国家是无产阶级专政的基础和前提;以责任制廉价政府代替官僚等级制政府是其主要形式;以议行合一原则取代分权制衡原则的权力分配形式可以保证国家机构的政治效能。中国共产党在长期执政实践中积累了丰富的执政经验,党的十九大提出中国特色社会主义已进入新时代。在此契机下重新研读马克思经典著作,对认识和把握中国共产党执政新飞跃、实现国家治理体系和治理能力现代化有着重大现实意义。     

Synergy evaluation of non-normalizable dose–response data: Generalization of combination index for the linear effect of drugs

The study of drug synergy plays a prominent role in the search for drug combinations with beneficial interactions. Firstly, in this process, the drug-effect response of individual parts and the mixture needs to be derived. This function is usually well described by Hill (or other logistic or sigmoid) curve. Due to its boundedness, it allows the measured data to be normalized. The normalized data can then be processed by interaction analysis using the Loewe, Bliss, or other models to evaluate possible synergy or antagonism of two or more drugs. However, sometimes, the drug-effect responses observed in pharmaceutical research do not appear to be bounded. Theoretically, the drug-effect curve cannot grow to infinity, but it may be impossible to determine its upper bound within the observed region. In this case, standard models cannot be used, since they assume that data are normalized. The approach of this article bypasses the need to normalize the data, allowing its broader application and usefulness in finding potential synergies in pharmaceutical research.     

道教文化的经济学内蕴

道教文化源远流长,博大精深,其间的一些主张与经济学有相通之处,如人性的判断,天人合一的主张,阴阳八卦的深奥及崇尚道德等,与西方经济中理性人假设,以人为本的科学发展观及信息经济学的诞生,诚信制度均在不同程度上存在相合之处;道教文化中蕴含着丰富的经济学思想。     

产业集群与二元结构反差的消除

产业集群在二元结构的反差中可以起到缩小反差的作用,作为区域增长极,它可以先是一个制造业基地,而后变成一个小城镇,继而发展成为一个大中城市,缩小城乡差别、工农差别和脑体差别。正因为产业集群可以缩小差别,所以,它能够在某种程度上缓解二元结构的内在矛盾。     

系列性权利组合:有限责任公司股东优先购买权性质新探

股东优先购买权体现出有限责任公司人合性与资合性之间的冲突。中国对于股东优先购买权的法律规范存在缺陷,其根本原因在于缺乏一套体系性的股东优先购买权理论。股东优先购买权本质上是系列性权利组合,而非单一的权利,具体包括资格维持请求权、告知请求权、强制缔约权和优先受领权。股东于其取得股东身份时取得优先购买权,并于此时得以行使。至于优先购买权的行使期限,则不宜做过多理论上的探讨,而应当交由立法者根据本国国情加以规定。     

论党的群众工作优良传统与社会工作创新

群众工作是我党的优良传统和政治优势,社会工作是解决社会问题的重要手段,在社会主义全面深化改革阶段,面临新的社会形势,群众工作与社会工作迫切需要创新。将党的群众工作优良传统与社会工作创新结合起来探讨,一方面有利于群众工作的创新;另一方面有利于社会工作的本土化发展。     

儒家“义—利”价值结构与西方“财富”价值结构比较研究简

通过中国儒家和西方经济价值结构的比较研究，发现儒家以“义一利”为价值结构模型，西方以“财富”为价值结构模型。儒家价值结构的基本特征是“义体利用”，表现方式是：强国的道义在于顺天时、尽地利、忠人和；安国的道义在于民朴民富；治国的道义在于蓄储俭用。西方价值结构的基本特征是“利体义用”，表现方式是：鼓励获取财富、财富规则和财富责任。儒家“义一利”价值结构与西方“财富”价值结构是两种不同的价值评判话语体系，在中国现代“义利共体”的价值结构建构中，儒家价值结构提供着人文精神基础，西方价值结构提供着物质文明建设可资借鉴的经验。