Testing equality of two normal covariance matrices with monotone missing data

Abstract

The problem of testing equality of two multivariate normal covariance matrices is considered. Assuming that the incomplete data are of monotone pattern, a quantity similar to the Likelihood Ratio Test Statistic is proposed. A satisfactory approximation to the distribution of the quantity is derived. Hypothesis testing based on the approximate distribution is outlined. The merits of the test are investigated using Monte Carlo simulation. Monte Carlo studies indicate that the test is very satisfactory even for moderately small samples. The proposed methods are illustrated using an example.     

Learning from a lot: Empirical Bayes for high‐dimensional model‐based prediction

Empirical Bayes is a versatile approach to “learn from a lot” in two ways: first, from a large number of variables and, second, from a potentially large amount of prior information, for example, stored in public repositories. We review applications of a variety of empirical Bayes methods to several well‐known model‐based prediction methods, including penalized regression, linear discriminant analysis, and Bayesian models with sparse or dense priors. We discuss “formal” empirical Bayes methods that maximize the marginal likelihood but also more informal approaches based on other data summaries. We contrast empirical Bayes to cross‐validation and full Bayes and discuss hybrid approaches. To study the relation between the quality of an empirical Bayes estimator and p, the number of variables, we consider a simple empirical Bayes estimator in a linear model setting. We argue that empirical Bayes is particularly useful when the prior contains multiple parameters, which model a priori information on variables termed “co‐data”. In particular, we present two novel examples that allow for co‐data: first, a Bayesian spike‐and‐slab setting that facilitates inclusion of multiple co‐data sources and types and, second, a hybrid empirical Bayes–full Bayes ridge regression approach for estimation of the posterior predictive interval.     

A volume based approach to establish B-spline based expressions for density functions and its application to progressive hybrid censoring

We propose an approach to determine the distribution of particular linear combinations of hybrid censored order statistics which is based on the calculation of volumes of polytopes. For this purpose, we establish efficient and compact volume formulas in terms of B-splines. Further, we illustrate our approach for ten different progressive hybrid censoring schemes under an exponential assumption.     

Progressive censoring with fixed censoring times

In this paper, we revisit the progressive Type-I censoring scheme as it has originally been introduced by Cohen [Progressively censored samples in life testing. Technometrics. 1963;5(3):327–339]. In fact, original progressive Type-I censoring proceeds as progressive Type-II censoring but with fixed censoring times instead of failure time based censoring times. Apparently, a time truncation has been added to this censoring scheme by interpreting the final censoring time as a termination time. Therefore, not much work has been done on Cohens's original progressive censoring scheme with fixed censoring times. Thus, we discuss distributional results for this scheme and establish exact distributional results in likelihood inference for exponentially distributed lifetimes. In particular, we obtain the exact distribution of the maximum likelihood estimator (MLE). Further, the stochastic monotonicity of the MLE is verified in order to construct exact confidence intervals for both the scale parameter and the reliability.     

Non-parametric estimation of reciprocal coordinate subtangent for right censored dependent scheme

The concept of reciprocal coordinate subtangent (RCST) has been used as a useful tool to study the monotone behavior of a continuous density function and for characterizing probability distributions. In this paper, we propose a non-parametric estimator for RCST based on the censored dependent data. Asymptotic properties of the estimator are established under suitable regularity conditions. A simulation study is carried out to examine the performance of the estimator. The usefulness of the estimator is also examined through a real data.     

Inference and optimal design of multiple constant-stress testing for generalized half-normal distribution under type-II progressive censoring

The generalized half-normal (GHN) distribution and progressive type-II censoring are considered in this article for studying some statistical inferences of constant-stress accelerated life testing. The EM algorithm is considered to calculate the maximum likelihood estimates. Fisher information matrix is formed depending on the missing information law and it is utilized for structuring the asymptomatic confidence intervals. Further, interval estimation is discussed through bootstrap intervals. The Tierney and Kadane method, importance sampling procedure and Metropolis-Hastings algorithm are utilized to compute Bayesian estimates. Furthermore, predictive estimates for censored data and the related prediction intervals are obtained. We consider three optimality criteria to find out the optimal stress level. A real data set is used to illustrate the importance of GHN distribution as an alternative lifetime model for well-known distributions. Finally, a simulation study is provided with discussion.     

Random effects regression mixtures for analyzing infant habituation

Random effects regression mixture models are a way to classify longitudinal data (or trajectories) having possibly varying lengths. The mixture structure of the traditional random effects regression mixture model arises through the distribution of the random regression coefficients, which is assumed to be a mixture of multivariate normals. An extension of this standard model is presented that accounts for various levels of heterogeneity among the trajectories, depending on their assumed error structure. A standard likelihood ratio test is presented for testing this error structure assumption. Full details of an expectation-conditional maximization algorithm for maximum likelihood estimation are also presented. This model is used to analyze data from an infant habituation experiment, where it is desirable to assess whether infants comprise different populations in terms of their habituation time.     

Estimating E-bayesian and hierarchical bayesian of scalar parameter of gompertz distribution under type II censoring schemes based on fuzzy data

In this study, the E-Bayesian and hierarchical Bayesian of the scalar parameter of a Gompertz distribution under Type II censoring schemes were estimated based on fuzzy data under the squared error (SE) loss function and the efficiency of the proposed methods was compared with each other and with the Bayesian estimator using Monte Carlo simulation.     

Modifications of sequential designs in bioequivalence trials

Bioequivalence (BE) studies are designed to show that two formulations of one drug are equivalent and they play an important role in drug development. When in a design stage, it is possible that there is a high degree of uncertainty on variability of the formulations and the actual performance of the test versus reference formulation. Therefore, an interim look may be desirable to stop the study if there is no chance of claiming BE at the end (futility), or claim BE if evidence is sufficient (efficacy), or adjust the sample size. Sequential design approaches specially for BE studies have been proposed previously in publications. We applied modification to the existing methods focusing on simplified multiplicity adjustment and futility stopping. We name our method modified sequential design for BE studies (MSDBE). Simulation results demonstrate comparable performance between MSDBE and the original published methods while MSDBE offers more transparency and better applicability. The R package MSDBE is available at https://sites.google.com/site/modsdbe/ . Copyright © 2015 John Wiley & Sons, Ltd.