脑心通对脑梗死患者血管内皮细胞和血小板功能的影响

目的 观察脑心通对急性脑梗死的临床疗效及其对脑梗死患者血管内皮细胞和血小板功能的影响.方法 62例急性脑梗死患者按入院顺序随机分为治疗组和对照组各31例.治疗组在常规治疗的基础上加脑心通4粒,tid,连续60d,并于治疗前后进行神经功能评估与血管内皮细胞和血小板功能测定.结果 脑心通组治疗后在神经功能明显改善的同时,血管内皮细胞和血小板功能亦得以改善.结论 脑心通具有保护血管内皮细胞和改善血小板功能的作用.     

Complete blood count parameters in peripheral arterial disease

Objective: To determine whether complete blood count parameters could be used as the biomarkers of inflammation in patients with in peripheral arterial disease.

Methods: Seventy-five patients with peripheral arterial disease (study group) and 75 healthy subjects (control group) were included in this retrospective study. Their baseline clinical characteristics and laboratory data were recorded and compared. Data were compared using univariate tests including independent samples t-test, Mann–Whitney U-test and chi-square test. Moreover, multivariate logistic regression analysis was also conducted to determine independent predictors of peripheral arterial disease.

Results: The groups were statistically similar with regards to baseline clinical and demographic features. The values of C-reactive protein, white blood cell and neutrophil-to-lymphocyte ratio values were found to be statistically significantly higher in study group versus control group, but none of them were considered as an independent predictor of peripheral arterial disease according to multivariate logistic regression analysis. Only mean platelet volume was demonstrated to be a statistically significant predictor of peripheral arterial disease.

Conclusion: Our study deduced that mean platelet volume was an independent predictor of peripheral arterial disease, and could be used as a marker of inflammation in patients with peripheral arterial disease.     

Could hemogram parameters be predictors of dementia in elderly patients?

Objective: To study red cell distribution width (RDW), RDW to platelet ratio (RPR) and mean platelet volume to platelet ratio (MPR), novel inflammatory markers of routine hemogram, of patients with or without dementia, according to the grade of the disease established by Fazekas’s score in magnetic resonance imaging (MRI).

Methods: A total of 1342 cases that undergone cranial MRI study were retrospectively analyzed. Patients without a previous stroke and over 45 years were enrolled in the study. Demographic and laboratory characteristics of the participants were obtained from institutional computerized database. Subcortical and periventricular white matter were evaluated in axial FLAIR images according to Fazekas’s grading scale. Univariate and multivariate analysis were performed for assessing the predictors of Fazekas’s grading scale.

Results: MPR of Fazekas 0, Fazekas 1, Fazekas 2 and Fazekas 3 groups were 3, 3, 4 and 3%, respectively. MPR difference between study groups was not significant (p?=?.32). RPR of Fazekas 0, Fazekas 1, Fazekas 2 and Fazekas 3 groups were 6, 7, 7 and 7%, respectively. RPR difference between study groups was significant (p?Conclusion: We suggest that increased RDW and RPR values may indicate higher Fazekas’s score and dementia in cranial imaging studies. The radiologist should pay particular attention in interpretation of cranial MRI of these patients.     

前列腺素E1对老年闭塞性周围动脉粥样硬化患者血小板功能的影响

目的观察前列腺素E1(PGE1)对老年闭塞性周围动脉粥样硬化(PAOD)患者血小板功能的影响。方法选择FontaineⅡ～Ⅲ级PAOD患者60例,观察应用PGE1前后患者血浆血小板膜α颗粒糖蛋白-140(GMP-140)、前列环素1α(6-k-PGFlα)、血栓素B2(TXB2)的变化。结果治疗后FontaineⅡ级及Ⅲ级患者疗效分别为显效11.1%,16.7%,有效61.1l%,52.38%,无效27.78%,30.95%,总有效率72.22%,69.05%;治疗前后血常规、凝血功能、肝肾功能、血糖、血脂检查结果均无明显变化(P>0.05),而GMP-140、6-k-PGFlα、TXB2较治疗前改变明显(P<0.05)。结论PGE1可以改善血小板功能,对老年PAOD患者安全有效,值得临床推广。