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1.
We develop methodology for a multistage-decision problem with flexible number of stages in which the rewards are survival times that are subject to censoring. We present a novel Q-learning algorithm that is adjusted for censored data and allows a flexible number of stages. We provide finite sample bounds on the generalization error of the policy learned by the algorithm, and show that when the optimal Q-function belongs to the approximation space, the expected survival time for policies obtained by the algorithm converges to that of the optimal policy. We simulate a multistage clinical trial with flexible number of stages and apply the proposed censored-Q-learning algorithm to find individualized treatment regimens. The methodology presented in this paper has implications in the design of personalized medicine trials in cancer and in other life-threatening diseases.  相似文献   
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Prior studies in the sociology of accidents have shown that different social groups have different rates of accident involvement. This study extends those studies by implementing Bourdieu's relational perspective of social space to systematically explore the homology between drivers’ social characteristics and their involvement in specific types of motor vehicle accident. Using a large database that merges official Israeli road‐accident records with socioeconomic data from two censuses, this research maps the social order of road accidents through multiple correspondence analysis. Extending prior studies, the results show that different social groups indeed tend to be involved in motor vehicle accidents of different types and severity. For example, we find that drivers from low socioeconomic backgrounds are overinvolved in severe accidents with fatal outcomes. The new findings reported here shed light on the social regularity of road accidents and expose new facets in the social organization of death.  相似文献   
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Attempts to limit global emissions of the greenhouse gases and in particular carbon dioxide must take account of the rapidly increasing populations and the continuing increase in the per-capita consumption of fossil fuels in much of the world. For many countries to achieve the target of a 20% cut in carbon dioxide emissions based on 1988 consumptions, far larger per-capita reductions are necessary. For Australia the cut is approximately 40%. The increases in global emissions of carbon dioxide resulting from the attainment of only very modest per-capita consumptions by the developing countries will far outweigh any reductions achieved by the developed world.Support for this project from the Australian Research Council is gratefully acknowledged.  相似文献   
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Gad Yair 《Social Identities》2013,19(4-5):346-362
The present paper extends recent studies of national character – suggesting that the Israeli case revolves around a set of deep cultural codes which constitute various empirical manifestations. Broadening on this re-emerging paradigm, the study provides a specific case study of a major trait of Israeli national character, namely existential anxiety and fear of annihilation. It does so while advancing the idea that cultural trauma sets a context for Israeli national character. The analysis shows that Israelis constantly reference persistent and endemic existential fears of annihilation. They do so while tying together four levels: the mythological predicament, historical evidence, contemporary threats and future risks.  相似文献   
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The control and treatment of dyslipidemia is a major public health challenge, particularly for patients with coronary heart diseases. In this paper we propose a framework for survival analysis of patients who had a major cardiac event, focusing on assessment of the effect of changing LDL-cholesterol level and statins consumption on survival. This framework includes a Cox PH model and a Markov chain, and combines their results into reinforced conclusions regarding the factors that affect survival time. We prospectively studied 2,277 cardiac patients, and the results show high congruence between the Markov model and the PH model; both evidence that diabetes, history of stroke, peripheral vascular disease and smoking significantly increase hazard rate and reduce survival time. On the other hand, statin consumption is correlated with a lower hazard rate and longer survival time in both models. The role of such a framework in understanding the therapeutic behavior of patients and implementing effective secondary and primary prevention of heart diseases is discussed here.  相似文献   
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Les auteurs reviennent sur la vision normative de l'OIT concernant le travail pénitentiaire, qu'ils jugent déconnectée de la réalité des prisons, où l'on constate un foisonnement de formes hybrides de travail des détenus, mêlant secteur public et secteur privé. Ils décrivent les controverses qui entourent la position de l'OIT, à l'heure où les États Membres pressent l'Organisation d'assouplir une vision dichotomique, toujours plus contestée. L'article montre les risques auxquels l'OIT s'expose si elle devait camper sur ses positions, mais aussi si elle adoptait la position défendue par certains de ses États Membres. Les auteurs proposent deux options permettant de dépasser ces positions antagonistes.  相似文献   
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We consider the estimation of a regression coefficient in a linear regression when observations are missing due to nonresponse. Response is assumed to be determined by a nonobservable variable which is linearly related to an observable variable. The values of the observable variable are assumed to be available for the whole sample but the variable is not includsd in the regression relationship of interest . Several alternative estimators have been proposed for this situation under various simplifying assumptions. A sampling theory approach provides three alternative estimatrs by considering the observatins as obtained from a sub-sample, selected on the basis of the fully observable variable , as formulated by Nathan and Holt (1980). Under an econometric approach, Heckman (1979) proposed a two-stage (probit and OLS) estimator which is consistent under specificconditions. A simulation comparison of the four estimators and the ordinary least squares estimator , under multivariate normality of all the variables involved, indicates that the econometric approach estimator is not robust to departures from the conditions underlying its derivation, while two of the other estimators exhibit a similar degree of stable performance over a wide range of conditions. Simulations for a non-normal distribution show that gains in performance can be obtained if observations on the independent variable are available for the whole population.  相似文献   
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Large‐scale, web‐based service marketplaces have recently emerged as a new resource for customers who need quick resolutions for their short‐term problems. Due to the temporary nature of the relations between customers and service providers (agents) in these marketplaces, customers may not have an opportunity to assess the ability of an agent before their service completion. On the other hand, the moderating firm has a more sustained relationship with agents, and thus it can provide customers with more information about the abilities of agents through skill screening mechanisms. In this study, we consider a marketplace where the moderating firm can run two skills tests on agents to assess if their skills are above certain thresholds. Our main objective is to evaluate the effectiveness of skill screening as a revenue maximization tool. We, specifically, analyze how much benefit the firm obtains after each additional skill test. We find that skill screening leads to negligible revenue improvements in marketplaces where agent skills are highly compatible and the average service times are similar for all customers. As the compatibility of agent skills weakens or the customers start to vary in their processing time needs, we show that the firm starts to experience sizable improvements in revenue from skill screening. Apparently, the firm can reap the most of these substantial benefits when it runs only one test. For instance, in marketplaces where agents posses uncorrelated skills, the second skill test only brings an additional 2% improvement in revenue. Accounting for possible skill screening costs, we then show the optimality of offering only one test when the compatibility between agent skills is sufficiently low. The results of this study also have important implications in terms of the right level of intervention in the marketplaces we study.  相似文献   
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