Mental health citizen surveys: a comparison of two within household telephone sampling techniques.

Two within household telephone sampling techniques for collecting citizen survey data for community mental health center's needs assessments were compared on the basis of respondent demographic characteristics; response, completion, and refusal rates; and, administrative costs. Initially, all households were chosen via random digit dialing. Then, one technique allowed the surveyor to interview any adult member of a household who answered the phone. The other technique used was developed by Troldahl and Carter and required the use of a reference table procedure to determine the appropriate respondent. While more expensive, the Troldahl-Carter method produced significantly better representativeness of the population for a rural county. Factors relating to a decision regarding which technique to employ are discussed.     

Hidden jobs: Good news for sociologists

Applied sociology, if defined broadly enough, is a ray of light for sociology graduates in an otherwise dismal career landscape. This is particularly true in the Washington, D. C. metropolitan area. Sociologists’ general or liberal arts skills are as valuable, if not more valuable, than research specialization. Finding a job in government requires a different strategy than a job with a government contractor. Unfortunately, in neither case is there a rational path or match-up between a person’s skills and finding the job which utilizes these skills. Local knowledge can help in making the match. Edward Sabin, Ph.D., University of Michigan 1970, taught sociology for five years in the Midwest. Since 1974, he worked for 8 years as a writer/researcher under a number of government contracts in the area of international health. Currently he is a writer/systems analyst for a NASA library automation project.     

Cofactors and markers of disease progression in human immunodeficiency virus infection

The identification of factors which are related to human immunodeficiency virus (HIV) disease progression, either by a direct interaction with HIV to increase the rate of disease progression or by providing an indication of an infected individual's likely prognosis, can have great value when understanding HIV pathogenesis and in the development of novel therapeutic approaches. This paper describes the roles of the CD4 cell count and the viral load as markers of disease progression and discusses the recent findings on chemokine receptors in HIV infection. Our current knowledge on these factors is summarized and unresolved statistical issues are highlighted.     

A Modular CDF Approach for the Approximation of Percentiles

This article describes a method for computing approximate statistics for large data sets, when exact computations may not be feasible. Such situations arise in applications such as climatology, data mining, and information retrieval (search engines). The key to our approach is a modular approximation to the cumulative distribution function (cdf) of the data. Approximate percentiles (as well as many other statistics) can be computed from this approximate cdf. This enables the reduction of a potentially overwhelming computational exercise into smaller, manageable modules. We illustrate the properties of this algorithm using a simulated data set. We also examine the approximation characteristics of the approximate percentiles, using a von Mises functional type approach. In particular, it is shown that the maximum error between the approximate cdf and the actual cdf of the data is never more than 1% (or any other preset level). We also show that under assumptions of underlying smoothness of the cdf, the approximation error is much lower in an expected sense. Finally, we derive bounds for the approximation error of the percentiles themselves. Simulation experiments show that these bounds can be quite tight in certain circumstances.     

A Different Perspective on Poverty in Lao PDR: Multidimensional Poverty in Lao PDR for the Years 2002/2003 and 2007/2008

This paper presents an indicator for measuring multidimensional poverty in the Lao People’s Democratic Republic applying the Alkire–Foster methodology to the Lao Expenditure and Consumption Survey 2002/2003 and 2007/2008. We calculated a multidimensional poverty index (MPI) that includes three dimensions: education, health, and standard of living. Making use of the MPI’s decomposability, we analyse how much each of the different dimensions and its respective indicators contribute to the overall MPI. We find a marked reduction in the multidimensional poverty headcount ratio over the study period, regardless of how the indicators are weighted or how the deprivation and poverty cut-offs are set. This reduction is based on improvements regarding all indicators except cooking fuel and nutrition. We observe no significant reduction in the intensity of poverty, however; there are wide disparities between the country’s regions and between urban and rural areas. The proportion of poor people in rural areas is more than twice as high as that in urban areas. By complementing the traditional income-based poverty measure, we hope to provide useful information that can support knowledge-based decision-making for poverty alleviation.     

A statistician's perspective on biomarkers in drug development

Biomarkers play an increasingly important role in many aspects of pharmaceutical discovery and development, including personalized medicine and the assessment of safety data, with heavy reliance being placed on their delivery. Statisticians have a fundamental role to play in ensuring that biomarkers and the data they generate are used appropriately and to address relevant objectives such as the estimation of biological effects or the forecast of outcomes so that claims of predictivity or surrogacy are only made based upon sound scientific arguments. This includes ensuring that studies are designed to answer specific and pertinent questions, that the analyses performed account for all levels and sources of variability and that the conclusions drawn are robust in the presence of multiplicity and confounding factors, especially as many biomarkers are multidimensional or may be an indirect measure of the clinical outcome. In all of these areas, as in any area of drug development, statistical best practice incorporating both scientific rigor and a practical understanding of the situation should be followed. This article is intended as an introduction for statisticians embarking upon biomarker-based work and discusses these issues from a practising statistician's perspective with reference to examples.     

Rapid Ethnographic Assessment of HIV/AIDS among Garífuna Communities in Honduras: Informing HIV Surveillance among Garífuna Women

ABSTRACT

Garífuna, an Afro-Caribbean ethnic group in Honduras, have among the highest HIV prevalence rates in Central America; 15- to 49-year-old Garífuna have HIV rates comparable to heterosexual transmission rates in regions of sub-Saharan Africa. The heightened rates in this age range pose a significant risk of vertical transmission from woman to child at birth. In 2006, a Behavioral Surveillance Survey plus Biomarkers (BSS+) reexamined seroprevalence of HIV, sexually transmitted infections, and HIV-related risk behaviors among Garífuna to inform HIV prevention activities and monitor trends in HIV transmission over time. To inform the BSS+ survey protocol, we conducted a rapid ethnographic assessment (REA) in Garífuna communities to specifically examine acceptability among Garífuna to be surveyed, suggest ways to minimize HIV-testing related stigma, and determine female gender-specific concerns among BSS+ respondents. Data were collected in 2 weeks in November, 2004, using a semi-structured interview guide for key informant interviews and focus groups. Seventeen key informant interviews and three focus groups were conducted; participant observation and 11 site visits were also conducted. Major findings included high Garífuna acceptability to participate in the BSS+ with key member involvement and incentives. Maintaining confidentiality at HIV testing sites is required to minimize Garífuna women's risk of intimate partner violence. Recommendations to BSS+ partners from this REA informed the BSS+ study protocol and was expected to increase participation and validity and decrease potential risks associated with women's survey participation.