Interleukin-18 and testosterone levels in men with metabolic syndrome

Objective: Interleukin 18 (IL-18) is an adipokine associated with obesity. Data about the relationship of IL-18 to the metabolic syndrome (MS) are still scarce. Low testosterone (T) levels are common in men with MS, but we did not find data about the levels of IL-18 in men with low T. The aim of this study was to determine the levels of IL-18 in men with MS with or without low T.

Patients and methods: A total of 251 men were included in the study. Of them 218 had MS (IDF 2005) and they were divided according to their morning total testosterone (TT) level (cutoff 10.4?nmol/l) into two groups: MS-low T (N?=?84) and MS-normal T (N?=?134). The control group consisted of 33 men without MS and low T. IL-18 was determined in serum using enzyme-linked immunosorbent assay. A small group of eight men with MS and low T levels received testosterone therapy for three months and physical and laboratory parameters were monitored at the end of that period.

Results: MS men were at mean age (±SD)?=?53.77?±?9.59 years; body mass index (BMI)?=?34.0?±?6.3?kg/m²; and TT?=?12.59?±?5.66?nmol/l. The control group was at age?=?52.12?±?5.2 years (NS); BMI?=?25.6?±?2.4?kg/m² (p?p?p?p?p?p?Conclusions: In this study, higher IL-18 levels were found in the presence of MS compared to healthy men, but they did not differ between men having MS with or without LOH.     

Essentialist Beliefs About Homosexuality Predict Positive and Negative Behavioral Intentions Toward Lesbian Women and Gay Men

This study focuses on essentialist beliefs about homosexuality as determinants of discriminatory intentions against gay men and lesbian women (LG) and the readiness to engage in positive action toward them. A sample of 997 exclusively heterosexual adults participated in an online study set in Croatia, a country with high homophobia undergoing social change that threatens the higher status of the heterosexual majority. Beliefs about immutability and universality of homosexuality were associated with less intention to discriminate and more readiness to engage in positive behavior, while discreteness beliefs were inversely related to both. Furthermore, attitudes toward LGs seem to be the mechanism behind the observed links. Results suggest essentialist beliefs might be fuel for attitudes, which are in turn associated with behavioral intentions. Importantly, essentialist beliefs had both indirect (with attitudes as mediators) and direct effects on behavioral intentions speaking in favor of their robust role in explaining LG-related phenomena.