Ticking fast or ticking slow, through Shc must you go?

Circumstantial evidence places the p66 isoform of the adapter protein Shc in a position to mediate the accelerated aging phenotype displayed by mice expressing shortened forms of the tumor suppressor protein p53. We present a model in which p66(shc) may be responsible for integrating signals from the p53 pathway with signals from the insulin-like growth factor-1/Daf pathway in mammals. A full understanding of how interactions between p53 and p66(shc) affect longevity will require the production of animals with mutations in the genes encoding both proteins.     

‘Class’, ‘Race’ and Language: imagining China and the discourse on the category ‘Han’ in the writing of Marxist revolutionary Qu Qiubai (1899–1935)

This study investigates the discursive peregrinations of the ‘Han’ category in the writings of the Chinese revolutionary, theoretician and activist Qu Qiubai. In the papers he wrote at the beginning of the 1930s dealing with the questions of language and writing, the author made singular use of the concept ‘Han’ to talk about the language/writing of the ‘Han’ (Hanzi, Hanyu) as a racial or ethnic group (Hanzu). Qu elaborated a discourse which articulated and mobilized, sometimes in a contradictory manner, the ‘Han’ category both as a ‘race’ and as a social class. Going beyond the race/class dialectic, I will try to show that these texts question the territorial, cultural and ethnic boundaries of ‘China’ and its homogeneity. Following this argument, this paper demonstrates how Qu's attempt to define ‘Chinese language(s)’ helps us to elucidate the complex articulation between China as a discursive and spatial category, the ‘Han’ category, and the other nationalities in the Chinese space. By questioning the homogeneity of the linguistic identity of China, using the word zhongguohua, Qu Qiubai unveiled an unstable and fragile imaginary relative to China and its so-called majority ethnic group, the Han.     

Pairwise likelihood estimation for multivariate mixed Poisson models generated by Gamma intensities

Estimating the parameters of multivariate mixed Poisson models is an important problem in image processing applications, especially for active imaging or astronomy. The classical maximum likelihood approach cannot be used for these models since the corresponding masses cannot be expressed in a simple closed form. This paper studies a maximum pairwise likelihood approach to estimate the parameters of multivariate mixed Poisson models when the mixing distribution is a multivariate Gamma distribution. The consistency and asymptotic normality of this estimator are derived. Simulations conducted on synthetic data illustrate these results and show that the proposed estimator outperforms classical estimators based on the method of moments. An application to change detection in low-flux images is also investigated.     

翻译“现代性”：瞿秋白思想探索

瞿秋白从自己的政治计划和意识形态立场出发，提出了对翻译实践和理论的一些看法。他的翻译思想受到了历史及其政治哲学理论背景的影响：首先，他从历史和时间的角度，认为他的中国位置和西方“现代性”之间有历史性的文化差异；其次，他对中国20世纪30年代语言异质性的表述与批评动摇了源语言与目标语言之间翻译的稳固关系；最后，他试图在理论上解决翻译所产生的差异问题。对瞿秋白来说，翻译成一个正在形成的、口头的、不保留过去语言踪迹的中国的普通话，才可以消灭翻译过程中所产生的差异。     

Priming Resistance to Persuasion decreases adherence to Conspiracy Theories*

Research in the field of Resistance to Persuasion (RP) has demonstrated that inoculating individuals with counter arguments is effective for lowering their levels of adherence to conspiracist beliefs (CB). Yet, this strategy is limited because it requires specific arguments tailored against targeted conspiracist narratives. Therefore, we investigated whether priming Resistance to Persuasion would reduce individual adherence to CB among undergraduate student samples. A first study (N = 81) demonstrated that participants primed by filling a RP scale had lower CB scores than control participants. This effect was directly replicated twice (N = 205 and N = 265) and confirmed by a mini meta-analysis (N = 519; d = .20). Practical and theoretical implications are then discussed.     

Block‐threshold‐adapted Estimators via a Maxiset Approach

We study the maxiset performance of a large collection of block thresholding wavelet estimators, namely the horizontal block thresholding family. We provide sufficient conditions on the choices of rates and threshold values to ensure that the involved adaptive estimators obtain large maxisets. Moreover, we prove that any estimator of such a family reconstructs the Besov balls with a near‐minimax optimal rate that can be faster than the one of any separable thresholding estimator. Then, we identify, in particular cases, the best estimator of such a family, that is, the one associated with the largest maxiset. As a particularity of this paper, we propose a refined approach that models method‐dependent threshold values. By a series of simulation studies, we confirm the good performance of the best estimator by comparing it with the other members of its family.     

A general class of inequality elasticities of poverty

Many authors have recently emphasized the crucial role of income inequalities in the design of efficient policies aimed at reducing poverty. However, the link between variations in the degree of inequality and variations in poverty is not well documented. The literature, for instance, does not provide any satisfying tool for predicting how a small relative variation in the Gini index may be associated with a variation in the headcount index. In the present paper, we define a family of Lorenz curve transformations that can directly be interpreted in terms of relative variations of known inequality measures. Then, we extend Kakwani’s (Rev Income Wealth 39(2):121–139, 1993) methodology for the calculation of inequality elasticities of poverty. Improvements are threefold with respect to Kakwani’s work. First, our formulas are not confined to the sole Gini index. Secondly, they embrace the uncertainty and the complexity of the mechanical link between inequality and poverty. Third, using some flexible functional form, one can easily perform an accurate estimation of the point inequality elasticities of poverty corresponding to observed variations of a given income distribution. We also propose a simple measure that may be helpful to assess how “pro-poor” are inequality variations by comparing the observed elasticities with the set of theoretical elasticities that could be obtained from the initial income distribution.     

Me,an entrepreneur? Entrepreneurial identity,outgroup social identification,attitudes and intentions towards business creation / ¿Yo,un emprendedor? Identidad emprendedora,identificación social con el exogrupo,actitudes e intenciones respecto a la creación de empresas

This article aims to further investigate the role of social identity processes in the formation of entrepreneurial intentions (EI). We investigate the general hypothesis that social identification with entrepreneurs is positively associated with EI and its antecedents such as attitude, perceived social norm (subjective norm) and perceived behavioural control (self-efficacy), considered as mediators. In particular, the role of three dimensions of social identification (affects, ties and self-typicality) was empirically studied in a sample of students that answered a questionnaire. Results from regression analyses show that the affects dimension is positively linked to attitude and the perceived social norm, which mediate its association with EI. Likewise, the ties dimension appears to relate positively to EI and attitude, the latter mediating the relationship with the former. Results regarding the self-typicality dimension are mixed (significant association with perceived behavioural control, non-significant association with EI). The discussion addresses the importance of social identity processes in EI formation, study limitations, as well as possible future studies of both theoretical and practical relevance.     

Suicidal tendency,physical health problems and addictive behaviours among general practitioners: their relationship with burnout

The aim of this article is to analyse further the association of burnout with (poor) physical health, addictive behaviours and suicidal tendency among general practitioners (GPs). Four hypotheses were studied: (H1): burnout (i.e. emotional exhaustion, EE, and depersonalization, DP) will be positively associated with suicidal tendency; (H2): will be negatively related to physical health (i.e. large number of physical symptoms and long-lasting impairment); and (H3): positively linked to addictive behaviours (i.e. addiction to alcohol and psychotropic medication) of GPs. Based on the “spiral of losses” depicted by the conservation of resources theory, we also considered whether physical health mediates the relationships of burnout/suicidal tendency and burnout/addictive behaviours (H4). 1890 French GPs completed a questionnaire administered by phone. Information was collected on burnout, three physical health indicators (BMI, number of physical symptoms and lasting physical health problems), four health behaviours (consumption of tobacco, alcohol, anxiolytics and antidepressants) and suicidal tendency (ideation, plan and attempt). Concerning EE, the results supported the hypotheses, except for alcohol consumption. However, the findings showed that DP was associated with more positive outcomes when controlling for exhaustion. The difference in findings for EE and DP are discussed, together with the need for GPs to develop strategies for resilience.