Work accommodation for people with multiple chemical sensitivity

Multiple chemical sensitivity (MCS) is a term used to describe allergic-like reactions to chemicals that represent everyday exposures in industrialized countries. It is sometimes associated with electromagnetic sensitivity, and both conditions are most likely engendered by environmental exposures. Prevalence studies suggest that chemical sensitivity affects 12-15% of the US population and that it crosses age, socio-economic status and racial lines. Electromagnetic sensitivity is less understood, but affects a portion of those with chemical sensitivity. Persons with these environmental sensitivities often experience difficulties with health care, housing and work. Workplace barriers result in significant disability, with ensuing financial loss and isolation for the worker. We examined work accommodations for 100 persons with self-reported MCS and its relation to life satisfaction. Results are discussed in terms of accommodating invisible disabilities that challenge industrial capitalism.     

Comparison of dichotomized and distributional approaches in rare event clinical trial design: a fixed Bayesian design

This research was motivated by our goal to design an efficient clinical trial to compare two doses of docosahexaenoic acid supplementation for reducing the rate of earliest preterm births (ePTB) and/or preterm births (PTB). Dichotomizing continuous gestational age (GA) data using a classic binomial distribution will result in a loss of information and reduced power. A distributional approach is an improved strategy to retain statistical power from the continuous distribution. However, appropriate distributions that fit the data properly, particularly in the tails, must be chosen, especially when the data are skewed. A recent study proposed a skew-normal method. We propose a three-component normal mixture model and introduce separate treatment effects at different components of GA. We evaluate operating characteristics of mixture model, beta-binomial model, and skew-normal model through simulation. We also apply these three methods to data from two completed clinical trials from the USA and Australia. Finite mixture models are shown to have favorable properties in PTB analysis but minimal benefit for ePTB analysis. Normal models on log-transformed data have the largest bias. Therefore we recommend finite mixture model for PTB study. Either finite mixture model or beta-binomial model is acceptable for ePTB study.     

Using a “child's‐eye view” of social success to understand the importance of school readiness at the transition to formal schooling

Recent research into school readiness has highlighted the importance of not only children's cognitive and socio‐emotional skills, but also the degree to which they have family support in the home. The current study examines the association between social success upon school entry and teacher‐ratings of school readiness as assessed by the Brief Early Skills and Support Index (BESSI), controlling for language ability. Importantly, social success was assessed using a “child's‐eye view” with peer‐reported assessments of both social preference and reciprocated friendships. A total of 244 children (131 boys, M_age = 61 months, SD = 4.78 months) in their first year of formal schooling participated. Child school readiness was found to be important for social preference, with the association being more marked for boys versus girls. Family support was the only independent predictor of children's reciprocated friendships. The use of the BESSI, with its broad scope compared to other measures of school readiness, highlights the importance of focusing both on a child's cognitive and socio‐emotional skills at school entry and their family support when exploring the association of school readiness to children's social success at the transition to formal schooling.     

Less than human: a qualitative study into the experience of parents involved in the child protection system

This paper reports on the findings from a qualitative study into the experiences of parents who were involved in the English child protection system in 2013. Seventeen in‐depth interviews were conducted involving 19 parents and/or partners, and a framework approach was used to analyse the data. There were positive experiences of individual social workers and some positive experiences of the child protection system. However, the overwhelming theme of the parents' experiences was that the system was uncaring, inflexible and for some harmful to both themselves and their children. Despite being included in the child protection process, parents felt they were not afforded the same rights as a participant, as a decision‐maker or as a partner in seeking to improve the situation. The threat of consequences silenced parents who felt unable to speak out or challenge the things they disagreed with or coerced others into signing agreements they did not agree to. Such experiences related to a sense that they were being treated as ‘less than human’. These findings are considered within the context of recent reforms within the English child protection system.     

Foodborne Exposure to Pesticides and Methylmercury in the United Arab Emirates

As part of a comprehensive environmental health strategic planning project initiated by the government of Abu Dhabi, we assessed potential dietary exposure in the United Arab Emirates (UAE) to methylmercury (in seafood) and pesticides (in fruits and vegetables) above international guideline levels. We present results for the UAE population by age, gender, and body mass index. Our results show very low daily risks of exposure to pesticides in fruits and vegetables at levels exceeding WHO guidelines even under the conservative assumption that no pesticides are removed during washing and food preparation. Thus, exposure to pesticides on fruits and vegetables does not appear to be a major public health concern in the UAE. The chances of exposure to methylmercury in seafood are much higher; our model estimates a mean 1 in 5 daily risk of exceeding the FAO/WHO provisional tolerable weekly intake. However, great caution should be used in interpreting these results, as we analyzed only the risks and not the substantial benefits of fish consumption. In fact, previous studies have demonstrated that exposure to the n‐3 polyunsaturated fatty acids in fish can increase IQ in developing children, and it can substantially decrease the risk in adults of coronary heart disease and stroke. Further research is warranted to compare the risk of Me‐Hg exposure from fish to the nutritional benefits of fish consumption in the UAE and to determine appropriate methods to communicate risk and benefit information to the UAE population.     

Powerblindness

In the land of the blind, the one‐eyed man may be king. But positions of power may produce their own forms of blindness. This paper reviews multiple theoretical approaches to the concept of powerblindness and categorizes these literatures into five forms through which powerblindness operates: powerblind identity (failure to notice that one belongs to a privileged group), powerblind egalitarianism (belief that all groups are equal in power), powerblind hierarchy (emphasis on one's own subordinate position), powerblind exception (the claim that one is less privileged than others in one's group), and powerblind justification (belief that present‐day hierarchy is merited or inevitable). The paper identifies studies offering evidence for each, drawing on social‐psychological experiments, survey data, and qualitative research, suggesting that power and knowledge do not necessarily go hand in hand – some forms of knowledge about the social order may be more visible to people with less power than to people with more.     

The NIP graph of a social welfare function

We consider the fraction of pairs of m distinct alternatives on which a social welfare function f may be nondictatorially independent and Pareto when the domain of f satisfies the free k-tuple property. When k = 4 we improve the existing upper bound to . When there are at least 26 alternatives and we obtain an original upper bound, . To obtain these results we define and analyze the graph formed from the nondictatorial independent and Pareto pairs and combine the results of this analysis with known results from extremal graph theory. The authors extend special thanks to the two reviewers and the editor for their comments.     

Exploiting proteomics in the discovery of drugs that target mitochondrial oxidative damage

To understand how oxidative stress contributes to aging and age-related diseases and to better evaluate the therapeutic effect of antioxidant drugs, it would be highly desirable to have a comprehensive and detailed readout of the types of oxidative damage that occur to proteins at a global or proteome level. In this Perspective, I examine how proteomics, defined here as the science of examining all proteins in an organelle, cell, or tissue in the context of biological phenomena, can be used to provide molecular details of mitochondrial protein oxidative damage. Specifically, I discuss approaches that combine knowledge of the mitochondrial proteome with newer mass spectrometry-based techniques that are capable of identifying proteins and sites of oxidative modification in a high-throughput manner.     

Caregiving role affects family relationships of African American grandmothers as new mothers again: a phenomenological perspective

Currently, African American grandmothers are becoming caregivers to grandchildren whose parents, for various reasons, are not providing them with adequate care. Replacing their adult children, as parents, while continuing to mother them along with caring for grandchildren are essential components of this complex situation. A part of the findings from this qualitative study of the experience of grandmother caregivers indicated that family relations are affected with their grandchildren, the parents of their grandchildren, and their other adult children. Implications for culturally sensitive, family-centered clinical practice and future research are discussed.