The impact of testosterone replacement therapy on glycemic control,vascular function,and components of the metabolic syndrome in obese hypogonadal men with type 2 diabetes

Objective: This study set out to assess effects of testosterone replacement therapy (TRT) on parameters of metabolic syndrome and vascular function in obese hypogonadal males with type 2 diabetes mellitus (DM2).

Study design: Fifty-five obese hypogonadal diabetic males on oral hypoglycemic treatment were enrolled into this one-year, double-blind, randomized, placebo-controlled clinical study. Group T (n?=?28) was treated with testosterone undecanoate (1000?mg i.m. every 10?weeks) while group P (n?=?27) received placebo.

Methods: Anthropometrical and vascular measurements – flow-mediated dilatation (FMD) and intima media thickness (IMT) – biochemical and hormonal blood sample analyses were performed at the start of the study and after one year. Derived parameters (BMI, HOMA-IR, calculated free testosterone (cFT) and bioavailable testosterone (BT)) were calculated.

Results: TRT resulted in reduction of HOMA-IR by 4.64?±?4.25 (p?p?p?=?.005).

Conclusion: TRT normalized serum testosterone levels, improved glycemic control and endothelial function while exerting no ill effects on the study population.     

Non‐linear Effects of Comparison Income in Quit Decisions: Status versus Signal!

This research note utilizes German matched employer–employee data to investigate the relationship between mobility and relative wage positions within establishments for workers without university degrees. The main innovation involves the examination of non‐linear effects, because previous literature mainly analyses mean linear effects. Our random‐effects probit estimates of mobility suggest a non‐linear U‐shaped effect with respect to relative standing. This is plausible because workers in low relative wage positions might quit because of their low status and those in high relative wage positions because of their low career advancement opportunities. Consideration of non‐linearities, thus, is a major improvement for the analysis of the effects of relative wage positions.     

Maternal depression,parental attributions,and adolescent psychopathology: An evaluation using observational and video-mediated recall methods

Parenting styles associated with maternal depression are a risk factor for adolescent psychopathology, and maternal attributional styles may be a key mechanism in this relationship. Mother-adolescent dyads (N = 180; 96 male; ages 10–15) completed in-person interactions and then the mothers participated in a video-mediated recall procedure to assess maternal attributions. Maternal depression was associated with negative attributions. Negative attributions were associated with low parental acceptance, aggressive parenting, and low positive parenting. Positive maternal attributions were associated with less aggressive parenting, and more positive parenting during one interaction task. Adolescent externalizing behaviors were associated with negative attributions. Future research should evaluate whether maternal attributions mediate the association between maternal depression and both parenting behaviors and adolescent mental health.     

Organizational design as a driver for firm innovativeness in Serbia

The area of innovation and innovation activities includes numerous aspects and changes needed to increase and improve the innovation potential of firms. Besides technological changes, organizational changes also play a very important role. Although these changes are considered within a wider innovation concept that is not limited merely to technological changes, they can significantly influence business improvement. Statistical data processing of an official pilot study – conducted by Statistical Office of the Republic of Serbia in cooperation with the Mihajlo Pupin Institute – illustrates the significance of organizational design regarding the innovative behavior of a company. It also points out that some elements of organizational design give a remarkable impetus to the innovative behavior of corporations, while others can be seen as a limiting factor. Detailed statistical analysis shows that one component of organizational design, namely the introduction of a new or significantly improved knowledge management system for a better use or exchange of information, knowledge and skills within companies, has the most influence on the innovation behavior of the company. Another component, a firm's completely new or significantly different relation with other firms or public institutions (such as alliances, partnerships, outsourcing or sub-contracting), has the least influence. These analyses are of crucial importance for defining the innovation pattern related to corporation management.     

Careers and productivity in an internal labor market

This paper contributes to the existing literature by evaluating the effects of age and tenure on careers and productivity within an internal labor market. We use the administrative personnel records of a long balanced panel of blue-collar workers from a manufacturing firm in Germany with a distinct classification of wage groups and unique information on workers’ productivity in form of suggestions for productivity improvement. Using robust locally weighted regression, our main findings suggest that the probability of promotion is highest for younger workers and early in the career. Older workers are less likely to be promoted. The likelihood of making a rewarded suggestion is inversely u-shaped with respect to tenure and age. Furthermore, workers’ ability and firm-specific human capital determine the workers’ careers and productivity.     

Handicaps in Job Assignment: Insiders,Outsiders and Gender

In this study, I use personnel data from a large German company in order to analyze handicaps in job assignment. First, I compare the productivity-relevant characteristics (university degree and work experience) and wages between insiders and outsiders as well as between men and women, who have been assigned to jobs at the same hierarchical level. Second, I estimate promotion probabilities and duration models for the time until the next promotion. The overall findings indicate a significant handicap in job assignment for outsiders with respect to schooling and little evidence that women are handicapped. While gender differences in wages within job levels and promotion probabilities are small, women have, on average, significantly less work experience than men at the same job level.     

A comparison of estimation procedures for the parameters of the star model

A simulation experiment compares the accuracy and precision of three alternate estimation techniques for the parameters of the STARMA model. Maximum likelihood estimation, in most ways the "best" estimation procedure, involves a large amount of computational effort so that two approximate techniques, exact least squares and conditional maximum likelihood, are often proposed for series of moderate lengths. This simulation experiment compares the accuracy of these three estimation procedures for simulated series of various lengths, and discusses the appropriateness of the three procedures as a function of the length of the observed series.     

Euthanasia on trial: examining public attitudes toward non-physician-assisted death

This study investigated the influence of various contextual effects on the decisions of subjects evaluating a case of nonphysician-assisted suicide. Subjects viewed a videotaped deposition of an individual emotionally or nonemotionally describing how he assisted in the death of his terminally ill wife by disconnecting her respirator or shooting her in the head. The deposition was followed by jury instructions that outlined the duties of the subject and, in some cases, was followed by a nullification instruction that informed the subjects of their right to ignore the law in this case if they felt it would culminate in an unfair verdict. After viewing the videotape, subjects were asked to rate the guilt of the individual as well as their confidence in this rating. Results indicate that the means of death and the type of instruction significantly affect guilt ratings. The implications of these findings are discussed.