Could gonadal and adrenal androgen deficiencies contribute to the depressive symptoms in men with systolic heart failure?

Background: Testosterone (TT) and dehydroepiandrosterone sulphate (DHEAS) are neurosteroids and their deficiencies constitute the hormone risk factors promoting the development of depression in elderly otherwise healthy men. We investigated the link between hypogonadism and depression in accordance with age and concomitant diseases in men with systolic HF using the novel scale previously dedicated for elderly population.

Methods: We analysed the prevalence of depression and severity of depressive symptoms in population of 226 men with systolic HF (40–80 years) compared to 379 healthy peers. The severity of depression was assessed using the Polish long version of Geriatric Depression Scale (GDS).

Results: In men aged 40–59 years the severity of depressive symptoms was greater in NYHA classes III–IV compared to NYHA classes I–II and reference group. In men aged 60–80 years depressive symptoms were more severe in NYHA class III-IV compared to controls (all p?≤?0.001). In multivariate logistic regression model in men aged 40–59 years advanced NYHA class was associated with higher prevalence of mild depression (OR?=?2.14, 95%CI: 1.07–4.29) and chronic obstructive pulmonary disease (COPD) with higher prevalence of severe depression (OR?=?69.1, 95%CI: 2.11–2264.3). In men aged 60–80 years advanced NYHA class and TT deficiency were related to higher prevalence of mild depression (respectively: OR?=?2.9, 95%CI: 1.3–6.4; OR?=?3.6, 95%CI: 1.2–10.63).

Conclusion: TT deficiency, COPD and advanced NYHA class were associated with higher prevalence of depression in men with systolic HF.     

Evaluation of objectivity, reliability and criterion validity of the key indicator method for manual handling operations (KIM-MHO), draft 2007

Upper extremity musculoskeletal symptoms and disorders are common in the working population. The economic and social impact of such disorders is considerable. Long-time, dynamic repetitive exposure of the hand-arm system during manual handling operations (MHO) alone or in combination with static and postural effort are recognised as causes of musculoskeletal symptoms and disorders. The assessment of these manual work tasks is crucial to estimate health risks of exposed employees. For these work tasks, a new method for the assessment of the working conditions was developed and a validation study was performed. The results suggest satisfying criterion validity and moderate objectivity of the KIM-MHO draft 2007. The method was modified and evaluated again. It is planned to release a new version of KIM-MHO in spring 2012.     

How diverse is Cologne carnival? How migrants appropriate popular art spaces

The present article contributes to the ongoing academic debate on migrants’ appropriation of artistic and political spaces in Germany. Cologne, one of the largest cities in Germany, is an interesting example of the tension between political discourse centred around multiculturalism and cultural segregation processes. The ‘no fool is illegal’ carnival organised by asylum seekers shows their capacity to act, as they reinvent an old local tradition by reinterpreting medieval rituals. Today, different groups and associations appropriate this festive art space: migrants, gays and lesbians, feminists and far-left groups either organise their own parties or take part in the official parties and parades as separate groups. As a result, the celebration of diversity figures on the local political agenda and becomes part of the official carnival festivities. This leads to a blurring of boundaries, whereby mainstream popular culture becomes more and more influenced by multicultural elements.     

Risky Business: Is There an Association between Casual Sex and Mental Health among Emerging Adults?

A multiethnic sample of single, heterosexual, emerging-adult college students (N = 3,907) ages 18 to 25, from 30 institutions across the United States, participated in a study about identity, culture, psychological well-being, and risky behaviors. Given ongoing debates about the connection between casual sex and psychological adjustment, in the current study we assessed the cross-sectional association of participation in casual sex with psychological well-being and distress. A greater proportion of men (18.6%) compared to women (7.4%) reported having had casual sex in the month prior to assessment. Structural equation modeling indicated that casual sex was negatively associated with well-being (ß = .20, p < .001) and positively associated with psychological distress (ß = .16, p < .001). Gender did not moderate these associations. For emerging-adult college students, engaging in casual sex may elevate risk for negative psychological outcomes.     

Estimation of a relative potency of two preparations with correlated responses

Estimation of a relative potency of two preparations in so-called parallel-line assays is presented. A special type of incomplete Latin square designs where doses of preparations are administered is considered. Testing hypotheses about similarity of preparations and their relative potency in the case of correlated observations are regarded. Confidence interval for the relative potency of preparations is also given. Theoretical considerations are applied to point and interval estimation of potencies of new tuberculins with respect to some international standards tested in experiments on guinea-pigs.     

Private Military and Security Labour Migration: The Case of Fiji

Private military and security companies (PMSCs) are a fast‐growing global industry. While the rise of PMSCs and their activities have attracted much media coverage and growing scholarly attention, little is known about their sourcing of masses of military labour from the global South. This exploratory study examines the case of Fiji, whose thousands of ex/current disciplinary force personnel and unemployed men have been contracted by PMSCs to provide security work in Iraq and other high‐conflict areas. The article shows this to be an instance of unequal core‐periphery military labour trade, outlining its scale, processes and impacts on the migrants. It also illuminates how the migrants’ collective agency is demonstrated even under powerful structural constraints.     

Are the Competent the Morally Good? Perspective Taking and Moral Motivation of Children Involved in Bullying

The present study tested the hypothesis of the cognitively competent but morally insensitive bully. On the basis of teacher and peer ratings, 212 young elementary school children were selected and categorized as bullies, bully–victims, victims, and prosocial children. Children's perspective-taking skills were assessed using theory-of-mind tasks, and moral motivation was assessed with a task about moral emotion attributions after moral rule transgressions. Analyses at the group level revealed that only bully–victims, but not bullies, were characterized by a deficit in perspective taking, while both aggressive groups showed a deficit in moral motivation. Analyses at the individual level, however, revealed that bullies were a more heterogeneous group, including children with an asymmetry between perspective taking and moral motivation, as well as children scoring consistently low or high on both measures. The findings highlight the importance of distinguishing between (1) strategic social–cognitive and moral competencies and (2) different subgroups of bullies.     

Evaluation of Research Ethics Committees: Criteria for the Ethical Quality of the Review Process

Repeatedly, adequacy, performance and quality of Ethics Committees that oversee medical research trials are being discussed. Although they play a crucial role in reviewing medical research and protecting human subjects, it is far from clear to what degree they fulfill the task they have been assigned to. This eventuates in the call for an evaluation of their activity and, in some places, led to the establishment of accreditation schemes. At the same time, IRBs have become subject of detailed legislation in the process of the ongoing global juridification of medical research. Unsurprisingly, there is a tendency to understand the evaluation of RECs as a question of controlling their legal compliance. This paper discusses the need for a quality evaluation of IRBs from an ethical point of view and, by systematically reviewing the major ethical guidelines for IRBs, proposes a system of criteria that should orientate any evaluation of IRBs.     

Gender Differences in Facial Reactions to Fear-Relevant Stimuli

The aim of the present study was to explore whether females are specifically more facially reactive than males, or whether females are more emotionally reactive in general, as reflected even by non-facial reactions such as autonomic responding and emotional experience. Forty-eight females and 48 males were exposed to pictures of fear-relevant and fear-irrelevant stimuli while EMG activity was detected from the Corrugator supercilii muscle region. Skin conductance responses (SCRs) were measured, and the participants were also required to rate how unpleasant they experienced the stimuli to be. Fear-relevant stimuli evoked a larger corrugator response than fear-irrelevant stimuli, but only for females. Fear-relevant stimuli also elicited larger SCRs and higher ratings of unpleasantness, but these measures were almost identical for females and males. The present results are consistent with the hypothesis that females are more facially reactive than males, but not more reactive in other respects.