Multiple facility location on a network with linear reliability order of edges

We study the problem of locating facilities on the nodes of a network to maximize the expected demand serviced. The edges of the input graph are subject to random failure due to a disruptive event. We consider a special type of failure correlation. The edge dependency model assumes that the failure of a more reliable edge implies the failure of all less reliable ones. Under this dependency model called Linear Reliability Order (LRO) we give two polynomial time exact algorithms. When two distinct LRO’s exist, we prove the total unimodularity of a linear programming formulation. In addition, we show that minimizing the sum of facility opening costs and expected cost of unserviced demand under two orderings reduces to a matching problem. We prove NP-hardness of the three orderings case and show that the problem with an arbitrary number of orderings generalizes the deterministic maximum coverage problem. When a demand point can be covered only if a facility exists within a distance limit, we show that the problem is NP-hard even for a single ordering.     

Making Sense of Neoliberal Subjectivity: A Discourse Analysis of Media Language on Self-development

The influence of neoliberalism on culture and subjectivity is well documented. This paper contributes to understanding of how neoliberal ideology enters into the production of subjectivity. While subject formation takes place in multiple and contradictory ways and across multiple social sites, we focus on the increasingly popular media discourse of self-development, and examine it as a technology of neoliberal subjectification. Drawing on Foucauldian understandings, we analyze data from two different newspapers from two different national contexts, both of which are heavily influenced by neoliberalism. Based on our analysis, we detail four interrelated discourses—rationality, autonomy and responsibility, entrepreneurship, and positivity and self-confidence—demonstrating how these discourses constitute the neoliberal subject in ways consonant with neoliberal governmentality. There is no observable resistance to subject positions offered within these discourses. Self-development discourse instills stronger individualism in society, while constraining collective identity, and thus provides social control and contributes to preserving status quo of neoliberal societies.     

Fortune d’une catégorie : la souffrance au travail chez les médecins du travail

For about 10 years now in France, doctors in occupational medicine have been using the category “suffering at work” to refer to what they consider to be new pathologies at the workplace. This category's diffusion in industrial medicine reveals the influence of a current in psychology (the “psychodynamics of work”) on these doctors. A qualitative study carried out with workplace doctors shows how a large percentage of them have appropriated this category. An active — and activist — fraction has wielded it to defend a new conception of industrial medicine's role, which centered around clinical practices, should pay more attention to workers’ subjective sense of suffering. In a context where the institutional prospects of industrial medicine are a cause of concern and where feelings of a lack of esteem have been revived in a profession that, since its origins, has been looking for legitimacy, the category of work-related suffering enables these doctors to win new territory and breathing room by transforming their line of work.     

A novel approach to subgraph selection with multiple weights on arcs

In this paper, an extension of the minimum cost flow problem is considered in which multiple incommensurate weights are associated with each arc. In the minimum cost flow problem, flow is sent over the arcs of a graph from source nodes to sink nodes. The goal is to select a subgraph with minimum associated costs for routing the flow. The problem is tractable when a single weight is given on each arc. However, in many real-world applications, several weights are needed to describe the features of arcs, including transit cost, arrival time, delay, profit, security, reliability, deterioration, and safety. In this case, finding an optimal solution becomes difficult. We propose a heuristic algorithm for this purpose. First, we compute the relative efficiency of the arcs by using data envelopment analysis techniques. We then determine a subgraph with efficient arcs using a linear programming model, where the objective function is based on the relative efficiency of the arcs. The flow obtained satisfies the arc capacity constraints and the integrality property. Our proposed algorithm has polynomial runtime and is evaluated in rigorous experiments.

     

Approximation Algorithms for the Multiple Knapsack Problem with Assignment Restrictions

Motivated by a real world application, we study the multiple knapsack problem with assignment restrictions (MKAR). We are given a set of items, each with a positive real weight, and a set of knapsacks, each with a positive real capacity. In addition, for each item a set of knapsacks that can hold that item is specified. In a feasible assignment of items to knapsacks, each item is assigned to at most one knapsack, assignment restrictions are satisfied, and knapsack capacities are not exceeded. We consider the objectives of maximizing assigned weight and minimizing utilized capacity.We focus on obtaining approximate solutions in polynomial computational time. We show that simple greedy approaches yield 1/3-approximation algorithms for the objective of maximizing assigned weight. We give two different 1/2-approximation algorithms: the first one solves single knapsack problems successively and the second one is based on rounding the LP relaxation solution. For the bicriteria problem of minimizing utilized capacity subject to a minimum requirement on assigned weight, we give an (1/3,2)-approximation algorithm.     

RigiScan data under long-term testosterone therapy: improving long-term blood circulation of penile arteries,penile length and girth,erectile function,and nocturnal penile tumescence and duration

Background: Late-onset hypogonadism (LOH) presents with low serum testosterone (TT) levels and sexual and nonsexual symptoms. Erectile dysfunction affects a man’s self-esteem and as a result partner relationship and quality of life.

Objectives: To investigate the andrological clinical profile outcomes of testosterone therapy (TTh) in men (n?=?88) with symptomatic LOH complaints and symptoms.

Main outcome measures: Erectile function was assessed using the International Index of Erectile Function-5 questionnaire at baseline and at 6 and 12 months of TTh. In addition, penile length was measured at baseline and 12 months. We also evaluated nocturnal penile tumescence (NPT, using RigiScan) and blood flow of cavernous arteries (penile Doppler ultrasonography) at baseline and 12 months of TT.

Materials and methods: Eighty-eight LOH men (M_age 51.1 years) with erectile dysfunction, all with serum TT?<10.4?nmol/L before TTh. Patients received intramuscular long-acting testosterone undecanoate for 12 months.

Results: Following TTh, in all patients, serum TT levels were restored within 3 months to normal levels. Compared with baseline values, erectile function significantly improved at 6 (mean score increase 1.95) and 12 months (mean score increase 2.16). No significant changes in penile length were observed. NPT significantly improved at 12 months in terms of both the frequency (mean increase 1.27 times) and duration of rigidity (mean increase 5.12?min). As regards the blood flow of the cavernous arteries, we observed a significant improvement (decrease of 1.16?cm/s) and end diastolic velocity of the penile arteries.

Conclusion: TTh in men with LOH resulted in improvement of the erectile function, NPT, and to some extent the blood flow of the cavernous arteries.     

Combining answers to direct and indirect questions: An implementation of Kuk’s randomized response model

Abstract

In this article, we propose a two folded approach for estimation of the population proportion of a sensitive attribute. The rationale of proposed technique is to give respondents choice if they want to avail randomized device or not. Thus, our technique is inherently capable of entertaining the responses attained through direct questioning and by employing randomization device, as well. We believe that free to choose policy will be helpful to develop a curtsy between interviewer and respondent (which is highly desirable, especially when sensitive issue is under consideration) and thus enhances the survey reliability. The proposed technique is developed for simple random sampling, at first, and then extended to stratified random sampling. The superior performance of proposed technique in comparison to the Kuk (1990 Kuk, A. Y. 1990. Asking sensitive questions indirectly. Biometrika 77 (2):436–8. doi:10.1093/biomet/77.2.436.[Crossref], [Web of Science ®] , [Google Scholar]) method is demonstrated throughout this article. We provide algebraic, graphical and numerical evidences in support of our proposed technique. Furthermore, we also offer cost analysis considering most commonly used cost functions in the literature of survey research.     

Early weight loss predicts the reduction of obesity in men with erectile dysfunction and hypogonadism undergoing long-term testosterone replacement therapy

We and others have previously shown that testosterone replacement therapy (TRT) results in sustained weight loss in the majority of middle-aged hypogonadal men. Previously, however, a small proportion failed to lose at least 5% of their baseline weight. The reason for this is not yet understood. In the present study, we sought to identify early indicators that may predict successful long-term weight loss, defined as a reduction of at least 5% of total body weight relative to baseline weight (T0), in men with hypogonadism undergoing TRT. Eight parameters measured were assessed as potential predictors of sustained weight loss: loss of 3% or more of baseline weight after 1 year of TU treatment, severe hypogonadism, BMI, waist circumference, International Prostate Symptom Score (IPSS), glycated hemoglobin (HbA_1C), age and use of vardenafil. Among the eight measured parameters, three factors were significantly associated with sustained weight loss over the entire period of TU treatment: (1) a loss of 3% of the baseline body weight after 1 year of TRT; (2) baseline BMI over 30; and (3) a waist circumference >102?cm. Age was not a predictor of weight loss.