Age and total and free prostate-specific antigen levels for predicting prostate volume in patients with benign prostatic hyperplasia

Objectives: To investigate the predictive values of free prostate-specific antigen (fPSA), total PSA (tPSA) and age on the prostate volume.

Methods: The data of 2148 patients with lower urinary tract symptoms were analyzed retrospectively. The patients who had transrectal ultrasonography guided 10 core biopsies owing to the findings obtained on digital rectal examination and presence of high PSA levels (PSA?=?2.5–10?ng/dl), and proven to have BPH histopathologically were included in the study. Age, tPSA, fPSA and the prostate volumes (PV) of the patients were noted.

Results: One thousand patients that fulfilled the inclusion criteria were included in the study. The PV of the patients were significantly correlated with age, tPSA and fPSA (p?r?=?0.307, p?r?=?0.382, p?r?=?0.296, respectively). On linear regression model, fPSA was found as a stronger predictive for PV (AUC?=?0.75, p?p?p?=?0.013).

Conclusions: Although tPSA is an important prognostic factor for predicting PV, the predictive value of fPSA is higher. PV can easily be predicted by using age, and serum tPSA and fPSA levels.     

Comparison of ANOVA-F and ANOM tests with regard to type I error rate and test power

A Monte Carlo simulation was conducted to compare the type I error rate and test power of the analysis of means (ANOM) test to the one-way analysis of variance F-test (ANOVA-F). Simulation results showed that as long as the homogeneity of the variance assumption was satisfied, regardless of the shape of the distribution, number of group and the combination of observations, both ANOVA-F and ANOM test have displayed similar type I error rates. However, both tests have been negatively affected from the heterogeneity of the variances. This case became more obvious when the variance ratios increased. The test power values of both tests changed with respect to the effect size (Δ), variance ratio and sample size combinations. As long as the variances are homogeneous, ANOVA-F and ANOM test have similar powers except unbalanced cases. Under unbalanced conditions, the ANOVA-F was observed to be powerful than the ANOM-test. On the other hand, an increase in total number of observations caused the power values of ANOVA-F and ANOM test approach to each other. The relations between effect size (Δ) and the variance ratios affected the test power, especially when the sample sizes are not equal. As ANOVA-F has become to be superior in some of the experimental conditions being considered, ANOM is superior in the others. However, generally, when the populations with large mean have larger variances as well, ANOM test has been seen to be superior. On the other hand, when the populations with large mean have small variances, generally, ANOVA-F has observed to be superior. The situation became clearer when the number of the groups is 4 or 5.     

Comparison of the effectiveness of IPSS and VPSS without any help in LUTS patients: a prospective study

Aim: To compare the correlation of visual prostate symptom score (VPSS) and international prostate symptom score (IPSS). To investigate the effect of educational level and age in the responses to VPSS and IPSS.

Method: Three hundred and nine patients who gave consent and applied via LUTS to our institution were included in this study. They were requested to fill IPSS and VPSS. The patients were divided into two groups as middle-aged and elderly with a cutoff point of 65?years. They were divided into six groups based on educational level. SPSS was used for the statistical evaluation.

Results: The mean age of the patients was 61.5?±?8.9?years. The correlation was found between IPSS and VPSS (p?p?=?.332 and .138, respectively). No difference was found between the middle-aged and elderly groups in terms of the rates of inability to answer IPSS and VPSS (p?=?.177 and .681, respectively).

Conclusions: There is a correlation between VPSS and IPSS. VPSS can be used as an auxiliary or alternative tool instead of IPSS in evaluating LUTS; however, has no superiority to IPSS in elderly group. Currently, the best option to exclude bias in illiterate group is VPSS.     

Evaluation of the relationship between compliance with the follow-up and treatment protocol and health literacy in bladder tumor patients

Abstract

Objective: To investigate the relationship between the compliance of bladder cancer patients with cystoscopic follow-up and the treatment protocol, and their health literacy.

Methods: Patients who underwent transurethral resection surgery for bladder tumor were found to have non-muscular invasive bladder carcinoma on pathology examination and then underwent cystoscopic follow-up for 1?year or more were included in the study. Cystoscopic follow-up was recommended to the low- and high-risk groups in terms of progression and recurrence. The patients were evaluated with the Health Literacy Survey-European Union scale.

Results: The mean age of the patients was 67.13?±?10.77 years. The treatment continuity rate was 80.50% (n?=?33) in the adequate health literacy group (n?=?41) and significantly higher than the 56.50% (n?=?48) rate in the inadequate health literacy group (n?=?85) (p?=?.008). The health literacy results revealed that the health promotion and general index score was higher in the group of patients under the age of 65.

Conclusions: Adequate health literacy in bladder cancer patients is associated with better compliance with the treatment protocol. Young patients show better compliance with the follow-up protocol recommended by the physician. Increasing the follow-up protocol compliance of elderly patients with inadequate health literacy is necessary.