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Many of the cost functions associated with depot location algorithms assume an overall demand for a fixed period, usually one year. This paper describes an investigation into the effect of high seasonality within such demand figures on the optimal location of storage facilities. The preliminary results indicate that a more flexible approach for certain products could be worthwhile. 相似文献
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Wout Slob Lya G. Soeteman-Hernández Wieneke Bil Yvonne C.M. Staal W. Edryd Stephens Reinskje Talhout 《Risk analysis》2020,40(7):1355-1366
Comparing the harmful health effects related to two different tobacco products by applying common risk assessment methods to each individual compound is problematic. We developed a method that circumvents some of these problems by focusing on the change in cumulative exposure (CCE) of the compounds emitted by the two products considered. The method consists of six steps. The first three steps encompass dose-response analysis of cancer data, resulting in relative potency factors with confidence intervals. The fourth step evaluates emission data, resulting in confidence intervals for the expected emission of each compound. The fifth step calculates the change in CCE, probabilistically, resulting in an uncertainty range for the CCE. The sixth step estimates the associated health impact by combining the CCE with relevant dose-response information. As an illustrative case study, we applied the method to eight carcinogens occurring both in the emissions of heated tobacco products (HTPs), a novel class of tobacco products, and tobacco smoke. The CCE was estimated to be 10- to 25-fold lower when using HTPs instead of cigarettes. Such a change indicates a substantially smaller reduction in expected life span, based on available dose-response information in smokers. However, this is a preliminary conclusion, as only eight carcinogens were considered so far. Furthermore, an unfavorable health impact related to HTPs remains as compared to complete abstinence. Our method results in useful information that may help policy makers in better understanding the potential health impact of new tobacco and related products. A similar approach can be used to compare the carcinogenicity of other mixtures. 相似文献
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The research reported here analyses data relating to bank services obtained by a stratified random sampling technique using stepwise linear regression and canonical correlation for the purpose of illustrating the application of segmentation principles to marketing research. 相似文献
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Stougaard Marianne Staal 《Voluntas: International Journal of Voluntary and Nonprofit Organizations》2021,32(6):1389-1407
VOLUNTAS: International Journal of Voluntary and Nonprofit Organizations - Including vulnerable citizens in public co-production can have a huge bearing on the quality and equity of the services on... 相似文献
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